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    Dsg4 desmoglein 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291754, updated on 26-Sep-2017
    Official Symbol
    Dsg4provided by RGD
    Official Full Name
    desmoglein 4provided by RGD
    Primary source
    RGD:735015
    See related
    Ensembl:ENSRNOG00000022364
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    cell adhesion molecule; involved in providing mechanical integrity and stability to epithelial cells [RGD, Feb 2006]
    Expression
    Biased expression in Muscle (RPKM 2.7), Heart (RPKM 0.4) and 1 other tissue See more
    Orthologs
    Location:
    18p12
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (12056113..12092858)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 18 NC_005117.3 (11853980..11888828)

    Chromosome 18 - NC_005117.4Genomic Context describing neighboring genes Neighboring gene similar to apoptosis inhibitor 5 Neighboring gene desmoglein 1 Neighboring gene trafficking protein particle complex subunit 8-like Neighboring gene meprin A subunit beta-like

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    calcium ion binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    hair follicle development IEA
    Inferred from Electronic Annotation
    more info
     
    hair follicle development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
     
    keratinocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    desmosome IEA
    Inferred from Electronic Annotation
    more info
     
    desmosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199490.1NP_955784.1  desmoglein-4 precursor

      See identical proteins and their annotated locations for NP_955784.1

      Status: PROVISIONAL

      Source sequence(s)
      AY314982
      UniProtKB/Swiss-Prot
      Q6W3B0
      Related
      ENSRNOP00000031941.2, ENSRNOT00000038450.2
      Conserved Domains (2) summary
      cd11304
      Location:161265
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam01049
      Location:790845
      Cadherin_C; Cadherin cytoplasmic region

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005117.4 Reference Rnor_6.0 Primary Assembly

      Range
      12056113..12092858
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000086.1 Alternate Rn_Celera

      Range
      11736765..11771810
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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