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    FST follistatin [ Homo sapiens (human) ]

    Gene ID: 10468, updated on 22-Apr-2017
    Official Symbol
    FSTprovided by HGNC
    Official Full Name
    follistatinprovided by HGNC
    Primary source
    HGNC:HGNC:3971
    See related
    Ensembl:ENSG00000134363 MIM:136470; Vega:OTTHUMG00000131183
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FS
    Summary
    Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    5q11.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 5 NC_000005.10 (53480338..53487134)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (52776183..52782964)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378965 Neighboring gene ribosomal protein S19 pseudogene 4 Neighboring gene NADH:ubiquinone oxidoreductase subunit S4 Neighboring gene long intergenic non-protein coding RNA 2105

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
    NHGRI GWA Catalog

    Replication interactions

    Interaction Pubs
    Knockdown of follistatin (FST) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    • Antagonism of Activin by Follistatin, organism-specific biosystem (from REACTOME)
      Antagonism of Activin by Follistatin, organism-specific biosystemBoth Follistatin (FST) and Follistatin-like-3 (FSTL3) irreversibly bind Activin dimers and prevent Activin from interacting with its receptor (reviewed in Schneyer et al. 2004 ,Xia and Schneyer 2009)...
    • BMP receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
      BMP receptor signaling, organism-specific biosystem
      BMP receptor signaling
    • Differentiation Pathway, organism-specific biosystem (from WikiPathways)
      Differentiation Pathway, organism-specific biosystemThis pathway provides an overview of the directed differentiation molecules used to induce early and derivative cell lineages from human pluripotent stem cells. The initial version of this pathway is...
    • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Activin, organism-specific biosystem (from REACTOME)
      Signaling by Activin, organism-specific biosystemActivin was initially discovered as an activator of follicle stimulating hormone in the pituitary gland. It has since been shown to be an important participant in the differentiation of embryonic cel...
    • TGF-beta Receptor Signaling, organism-specific biosystem (from WikiPathways)
      TGF-beta Receptor Signaling, organism-specific biosystemThe Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiat...
    • TGF-beta signaling pathway, organism-specific biosystem (from KEGG)
      TGF-beta signaling pathway, organism-specific biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
    • TGF-beta signaling pathway, conserved biosystem (from KEGG)
      TGF-beta signaling pathway, conserved biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    activin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    heparan sulfate proteoglycan binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signal transducer activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular region TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    follistatin
    Names
    activin-binding protein
    follistatin isoform FST317

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028911.1 RefSeqGene

      Range
      5001..11041
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_006350.3NP_006341.1  follistatin isoform FST317 precursor

      See identical proteins and their annotated locations for NP_006341.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (FST317) uses an alternate splice junction at the 5' end of an exon compared to variant, that causes a frameshift. The resulting isoform (FST317) has a shorter and distinct C-terminus compared to isoform FST344.
      Source sequence(s)
      BC004107, BQ941144, BQ949678, DR760015
      Consensus CDS
      CCDS43315.1
      UniProtKB/Swiss-Prot
      P19883
      Related
      ENSP00000380151.2, OTTHUMP00000221843, ENST00000396947.7, OTTHUMT00000319781
      Conserved Domains (2) summary
      smart00274
      Location:94117
      FOLN; Follistatin-N-terminal domain-like
      smart00280
      Location:117164
      KAZAL; Kazal type serine protease inhibitors
    2. NM_013409.2NP_037541.1  follistatin isoform FST344 precursor

      See identical proteins and their annotated locations for NP_037541.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (FST344) encodes the longer isoform (FST344).
      Source sequence(s)
      BC004107, BQ941144, DR760015
      Consensus CDS
      CCDS3959.1
      UniProtKB/Swiss-Prot
      P19883
      UniProtKB/TrEMBL
      A0A024QZU6
      Related
      ENSP00000256759.3, OTTHUMP00000161829, ENST00000256759.7, OTTHUMT00000253906
      Conserved Domains (2) summary
      smart00274
      Location:94117
      FOLN; Follistatin-N-terminal domain-like
      smart00280
      Location:117164
      KAZAL; Kazal type serine protease inhibitors

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p7 Primary Assembly

      Range
      53480338..53487134
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017008954.1XP_016864443.1  follistatin isoform X4

    2. XM_005248402.4XP_005248459.1  follistatin isoform X5

      Conserved Domains (2) summary
      smart00274
      Location:94117
      FOLN; Follistatin-N-terminal domain-like
      smart00280
      Location:117164
      KAZAL; Kazal type serine protease inhibitors
    3. XM_005248400.4XP_005248457.1  follistatin isoform X1

      Conserved Domains (2) summary
      smart00274
      Location:94117
      FOLN; Follistatin-N-terminal domain-like
      smart00280
      Location:117164
      KAZAL; Kazal type serine protease inhibitors
    4. XM_005248403.4XP_005248460.1  follistatin isoform X6

      See identical proteins and their annotated locations for XP_005248460.1

      Conserved Domains (2) summary
      smart00274
      Location:94117
      FOLN; Follistatin-N-terminal domain-like
      smart00280
      Location:117164
      KAZAL; Kazal type serine protease inhibitors
    5. XM_005248401.4XP_005248458.1  follistatin isoform X3

      See identical proteins and their annotated locations for XP_005248458.1

      Conserved Domains (2) summary
      smart00274
      Location:94117
      FOLN; Follistatin-N-terminal domain-like
      smart00280
      Location:117164
      KAZAL; Kazal type serine protease inhibitors
    6. XM_017008955.1XP_016864444.1  follistatin isoform X7

    7. XM_011543099.2XP_011541401.1  follistatin isoform X2

      Conserved Domains (3) summary
      smart00274
      Location:162185
      FOLN; Follistatin-N-terminal domain-like
      smart00280
      Location:112159
      KAZAL; Kazal type serine protease inhibitors
      pfam09289
      Location:90111
      FOLN; Follistatin/Osteonectin-like EGF domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018916.2 Alternate CHM1_1.1

      Range
      52779193..52785231
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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