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    Mdk midkine [ Mus musculus (house mouse) ]

    Gene ID: 17242, updated on 6-Aug-2017
    Official Symbol
    Mdkprovided by MGI
    Official Full Name
    midkineprovided by MGI
    Primary source
    MGI:MGI:96949
    See related
    Ensembl:ENSMUSG00000027239 Vega:OTTMUSG00000014364
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MK; Mek
    Summary
    This gene encodes a secreted growth factor that belongs to the pleiotrophin/midkine heparin-binding protein family and functions in a variety of biological processes. The encoded cytokine promotes the growth, differentiation, survival and migration of several target cells including leucocytes involved in inflammation. This protein plays a role in the formation of scar tissue and intraperitoneal adhesions, and promotes neurite outgrowth and neuron survival. The protein encoded by this gene is associated with obesity and inhibition of insulin signaling in fat cells. A pseudogene of this gene is present on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
    Orthologs
    Location:
    2 E1; 2 50.63 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (91929805..91932297, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (91769978..91772439, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene harbinger transposase derived 1 Neighboring gene dyskeratosis congenita 1, dyskerin homolog pseudogene Neighboring gene autophagy/beclin 1 regulator 1 Neighboring gene cholinergic receptor, muscarinic 4 Neighboring gene predicted gene, 39876 Neighboring gene microRNA 6999 Neighboring gene diacylglycerol kinase zeta Neighboring gene cAMP responsive element binding protein 3-like 1 Neighboring gene predicted gene, 31473

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    heparin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    adrenal gland development ISO
    Inferred from Sequence Orthology
    more info
     
    behavioral fear response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    cerebellar granular layer development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cerebral cortex development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    defecation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dentate gyrus development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    hippocampus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neuron apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of neuron death IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to wounding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to wounding ISO
    Inferred from Sequence Orthology
    more info
     
    short-term memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cell projection ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    midkine
    Names
    retinoic acid-induced differentiation factor
    retinoic acid-responsive protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012335.2NP_001012335.1  midkine isoform a precursor

      See identical proteins and their annotated locations for NP_001012335.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 through 4 encode the same isoform (a).
      Source sequence(s)
      AL731772, CF728526, CF738400
      Consensus CDS
      CCDS16440.1
      UniProtKB/Swiss-Prot
      P12025
      Related
      ENSMUSP00000088090.5, OTTMUSP00000015222, ENSMUST00000090602.5, OTTMUST00000033985
      Conserved Domains (1) summary
      smart00193
      Location:34113
      PTN; Pleiotrophin / midkine family
    2. NM_001012336.2NP_001012336.1  midkine isoform a precursor

      See identical proteins and their annotated locations for NP_001012336.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also known as MK2; PMID 2345177) differs in the 5' UTR compared to variant 1. Variants 1 through 4 encode the same isoform (a).
      Source sequence(s)
      AL731772, BY092625, CF728526, M34327
      Consensus CDS
      CCDS16440.1
      UniProtKB/Swiss-Prot
      P12025
      Related
      ENSMUSP00000068413.6, OTTMUSP00000015221, ENSMUST00000069423.12, OTTMUST00000033984
      Conserved Domains (1) summary
      smart00193
      Location:34113
      PTN; Pleiotrophin / midkine family
    3. NM_001291481.1NP_001278410.1  midkine isoform a precursor

      See identical proteins and their annotated locations for NP_001278410.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 through 4 encode the same isoform (a).
      Source sequence(s)
      CF728526, CJ174056
      Consensus CDS
      CCDS16440.1
      UniProtKB/Swiss-Prot
      P12025
      Related
      ENSMUSP00000106941.1, OTTMUSP00000015223, ENSMUST00000111309.7, OTTMUST00000033986
      Conserved Domains (1) summary
      smart00193
      Location:34113
      PTN; Pleiotrophin / midkine family
    4. NM_001291482.1NP_001278411.1  midkine isoform b

      See identical proteins and their annotated locations for NP_001278411.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream start codon compared to variant 1. The encoded isoform (b) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AL731772, BY092625, CF728526, CJ174578
      Conserved Domains (1) summary
      cl02505
      Location:163
      PTN_MK_N; PTN/MK heparin-binding protein family, N-terminal domain
    5. NM_001291483.1NP_001278412.1  midkine isoform c precursor

      See identical proteins and their annotated locations for NP_001278412.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an alternate in-frame exon in the central coding region compared to variant 1. The encoded isoform (c) is shorter than isoform 1.
      Source sequence(s)
      AL731772
      UniProtKB/TrEMBL
      Q2LEK5
      Conserved Domains (1) summary
      cl02505
      Location:3479
      PTN_MK_N; PTN/MK heparin-binding protein family, N-terminal domain
    6. NM_010784.5NP_034914.1  midkine isoform a precursor

      See identical proteins and their annotated locations for NP_034914.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as MK3; PMID 2345177) represents the longest transcript and encodes the longest isoform (a). Variants 1 through 4 encode the same isoform.
      Source sequence(s)
      AL731772, CF728526, M34328
      Consensus CDS
      CCDS16440.1
      UniProtKB/Swiss-Prot
      P12025
      Related
      ENSMUSP00000028672.6, OTTMUSP00000015220, ENSMUST00000028672.12, OTTMUST00000033983
      Conserved Domains (1) summary
      smart00193
      Location:34113
      PTN; Pleiotrophin / midkine family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      91929805..91932297 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239335.2XP_011237637.1  midkine isoform X1

      See identical proteins and their annotated locations for XP_011237637.1

      Conserved Domains (1) summary
      cl02505
      Location:163
      PTN_MK_N; PTN/MK heparin-binding protein family, N-terminal domain
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