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    Myo10 myosin X [ Mus musculus (house mouse) ]

    Gene ID: 17909, updated on 9-Jan-2018
    Official Symbol
    Myo10provided by MGI
    Official Full Name
    myosin Xprovided by MGI
    Primary source
    MGI:MGI:107716
    See related
    Ensembl:ENSMUSG00000022272 Vega:OTTMUSG00000020342
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AW048724; myosin-X; mKIAA0799; D15Ertd600e
    Expression
    Ubiquitous expression in lung adult (RPKM 20.6), ovary adult (RPKM 15.7) and 28 other tissues See more
    Orthologs
    Location:
    15 B1; 15 9.36 cM
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (25622550..25813671)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (25552305..25743426)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene brain abundant, membrane attached signal protein 1 Neighboring gene predicted gene 5468 Neighboring gene PCNA-associated factor pseudogene Neighboring gene reticulophagy regulator 1 Neighboring gene peptidyl-prolyl cis-trans isomerase A pseudogene 15_175.1 Neighboring gene microRNA 7212

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Spontaneous (1) 
    • Gene trapped (1) 
    • Targeted (2) 
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    motor activity ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    spectrin binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    cell motility IC
    Inferred by Curator
    more info
    PubMed 
    positive regulation of cell-cell adhesion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    filopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    myosin complex IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    ruffle ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    unconventional myosin-X
    Names
    unconventional myosin-10
    unconventionnal myosin-X

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001353141.1NP_001340070.1  unconventional myosin-X isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC131178
      Conserved Domains (8) summary
      smart00139
      Location:9111057
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:10661320
      B41; Band 4.1 homologues
      cd13202
      Location:13161404
      FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
      cd13296
      Location:577678
      PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
      cd13297
      Location:743868
      PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
      cl17171
      Location:543585
      PH-like; Pleckstrin homology-like domain
      cl22853
      Location:285
      Motor_domain; Myosin and Kinesin motor domain
      cl27381
      Location:3334
      Myosin_head; Myosin head (motor domain)
    2. NM_001353142.1NP_001340071.1  unconventional myosin-X isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AK122371
      Conserved Domains (8) summary
      smart00139
      Location:807953
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:9621216
      B41; Band 4.1 homologues
      cd13202
      Location:12121300
      FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
      cd13296
      Location:473574
      PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
      cd13297
      Location:639764
      PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
      pfam16735
      Location:143186
      MYO10_CC; Unconventional myosin-X coiled coil domain
      cl17171
      Location:439481
      PH-like; Pleckstrin homology-like domain
      cl25642
      Location:98235
      DUF390; Protein of unknown function (DUF390)
    3. NM_019472.2NP_062345.2  unconventional myosin-X isoform 1

      See identical proteins and their annotated locations for NP_062345.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK028552, AK089482, AK122371
      Consensus CDS
      CCDS37049.1
      UniProtKB/Swiss-Prot
      F8VQB6
      UniProtKB/TrEMBL
      Q80TR9
      Related
      ENSMUSP00000106087.1, OTTMUSP00000022066, ENSMUST00000110457.7, OTTMUST00000048259
      Conserved Domains (15) summary
      smart00015
      Location:741763
      IQ; Calmodulin-binding motif
      smart00139
      Location:15531699
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00242
      Location:58739
      MYSc; Myosin. Large ATPases
      smart00295
      Location:17081962
      B41; Band 4.1 homologues
      cd13202
      Location:19582046
      FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
      cd13296
      Location:12191320
      PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
      cd13297
      Location:13851510
      PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
      cd14873
      Location:77727
      MYSc_Myo10; class X myosin, motor domain
      pfam00169
      Location:12191314
      PH; PH domain
      pfam00373
      Location:18031962
      FERM_M; FERM central domain
      pfam15346
      Location:796939
      ARGLU; Arginine and glutamate-rich 1
      pfam16735
      Location:882932
      MYO10_CC; Unconventional myosin-X coiled coil domain
      cl00155
      Location:17051750
      UBQ; Ubiquitin-like proteins
      cl02488
      Location:843957
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl17171
      Location:11851227
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      25622550..25813671
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520025.3XP_006520088.1  unconventional myosin-X isoform X2

      UniProtKB/Swiss-Prot
      F8VQB6
      Conserved Domains (13) summary
      smart00015
      Location:98120
      IQ; Calmodulin-binding motif
      smart00139
      Location:9101056
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:10651319
      B41; Band 4.1 homologues
      cd13202
      Location:13151403
      FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
      cd13296
      Location:576677
      PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
      cd13297
      Location:742867
      PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
      cl22853
      Location:184
      Motor_domain; Myosin and Kinesin motor domain
      pfam00169
      Location:576669
      PH; PH domain
      pfam00373
      Location:11601319
      FERM_M; FERM central domain
      pfam16735
      Location:239289
      MYO10_CC; Unconventional myosin-X coiled coil domain
      cl00155
      Location:10621107
      UBQ; Ubiquitin-like proteins
      cl02488
      Location:200314
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl17171
      Location:542584
      PH-like; Pleckstrin homology-like domain
    2. XM_006520024.3XP_006520087.1  unconventional myosin-X isoform X1

      Conserved Domains (8) summary
      smart00139
      Location:9111057
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:10661320
      B41; Band 4.1 homologues
      cd13202
      Location:13161404
      FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
      cd13296
      Location:577678
      PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
      cd13297
      Location:743868
      PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
      cl17171
      Location:543585
      PH-like; Pleckstrin homology-like domain
      cl22853
      Location:285
      Motor_domain; Myosin and Kinesin motor domain
      cl27381
      Location:3334
      Myosin_head; Myosin head (motor domain)
    3. XM_006520026.3XP_006520089.1  unconventional myosin-X isoform X3

      Related
      ENSMUSP00000022882.5, OTTMUSP00000022073, ENSMUST00000022882.11, OTTMUST00000048267
      Conserved Domains (12) summary
      smart00015
      Location:1941
      IQ; Calmodulin-binding motif
      smart00139
      Location:831977
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:9861240
      B41; Band 4.1 homologues
      cd13202
      Location:12361324
      FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
      cd13296
      Location:497598
      PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
      cd13297
      Location:663788
      PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
      pfam00169
      Location:497590
      PH; PH domain
      pfam00373
      Location:10811240
      FERM_M; FERM central domain
      pfam16735
      Location:160210
      MYO10_CC; Unconventional myosin-X coiled coil domain
      cl00155
      Location:9831028
      UBQ; Ubiquitin-like proteins
      cl02488
      Location:121235
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl17171
      Location:463505
      PH-like; Pleckstrin homology-like domain
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