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    SIRPA signal regulatory protein alpha [ Homo sapiens (human) ]

    Gene ID: 140885, updated on 21-Dec-2017
    Official Symbol
    SIRPAprovided by HGNC
    Official Full Name
    signal regulatory protein alphaprovided by HGNC
    Primary source
    HGNC:HGNC:9662
    See related
    Ensembl:ENSG00000198053 MIM:602461; Vega:OTTHUMG00000031682
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BIT; MFR; P84; SIRP; MYD-1; SHPS1; CD172A; PTPNS1
    Summary
    The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 71.2), appendix (RPKM 27.2) and 23 other tissues See more
    Orthologs
    Location:
    20p13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 20 NC_000020.11 (1894117..1939895)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (1874763..1920540)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984104 Neighboring gene uncharacterized LOC105372501 Neighboring gene uncharacterized LOC107984088 Neighboring gene uncharacterized LOC102724545 Neighboring gene PDYN antisense RNA 1 Neighboring gene prodynorphin Neighboring gene ribosomal protein L7 pseudogene 2

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.
    NHGRI GWA Catalog
    Genome-wide association study of liver enzymes in korean children.
    NHGRI GWA Catalog
    Genome-wide joint SNP and CNV analysis of aortic root diameter in African Americans: the HyperGEN study.
    NHGRI GWA Catalog
    New gene functions in megakaryopoiesis and platelet formation.
    NHGRI GWA Catalog
    • Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystem (from WikiPathways)
      Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is a neurotrophin essential for growth, differentiation, plasticity, and survival of neurons. BDNF is also required for processes such as energy metabolism, b...
    • Cardiac Progenitor Differentiation, organism-specific biosystem (from WikiPathways)
      Cardiac Progenitor Differentiation, organism-specific biosystemFactors involved in the induction of cardiac differentiation in vitro and in vivo. This model was based on the below two review articles.
    • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
      Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
    • Cell-Cell communication, organism-specific biosystem (from REACTOME)
      Cell-Cell communication, organism-specific biosystemCell-to-Cell communication is crucial for multicellular organisms because it allows organisms to coordinate the activity of their cells. Some cell-to-cell communication requires direct cell-cell cont...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
      Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
    • Osteoclast differentiation, organism-specific biosystem (from KEGG)
      Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Osteoclast differentiation, conserved biosystem (from KEGG)
      Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Prolactin Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Prolactin Signaling Pathway, organism-specific biosystemProlactin (PRL), a pleiotropic polypeptide hormone, mostly secreted by the lactotrophic cells of anterior pituitary gland and to a lesser extent expressed in numerous extra pituitary tissues such as ...
    • Signal regulatory protein (SIRP) family interactions, organism-specific biosystem (from REACTOME)
      Signal regulatory protein (SIRP) family interactions, organism-specific biosystemSignal regulatory protein (SIRP)alpha, also known as SHPS-1 or SIRPA or CD172a, is a transmembrane protein expressed mostly on myeloid cells. CD47, a widely expressed transmembrane protein, is a liga...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    leukocyte migration TAS
    Traceable Author Statement
    more info
     
    neutrophil degranulation TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    extracellular exosome HDA PubMed 
    ficolin-1-rich granule membrane TAS
    Traceable Author Statement
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    tertiary granule membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    tyrosine-protein phosphatase non-receptor type substrate 1
    Names
    CD172 antigen-like family member A
    brain-immunoglobulin-like molecule with tyrosine-based activation motifs
    inhibitory receptor SHPS-1
    macrophage fusion receptor
    myd-1 antigen
    tyrosine phosphatase SHP substrate 1
    NP_001035111.1
    NP_001035112.1
    NP_542970.1
    XP_005260726.1
    XP_005260727.1
    XP_006723608.1
    XP_011527475.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040022.1NP_001035111.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001035111.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) uses an alternate, in-frame, splice donor site in the 3' coding region compared to variant 4. This variant encodes a shorter protein (isoform 1) compared to isoform 2. Variants 1, 2, and 3 encode the same protein (isoform 1).
      Source sequence(s)
      AL034562, BC075849, DA471662, DN989886
      Consensus CDS
      CCDS13022.1
      UniProtKB/Swiss-Prot
      P78324
      Related
      ENSP00000382941.4, ENST00000400068.7
      Conserved Domains (4) summary
      cd00098
      Location:266339
      IgC; Immunoglobulin Constant domain
      smart00410
      Location:41144
      IG_like; Immunoglobulin like
      pfam07686
      Location:38145
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:143254
      Ig; Immunoglobulin domain
    2. NM_001040023.1NP_001035112.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001035112.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate, in-frame, splice donor site in the 3' coding region compared to variant 4. This variant encodes a shorter protein (isoform 1) compared to isoform 2. Variants 1, 2, and 3 encode the same protein (isoform 1).
      Source sequence(s)
      AL034562, BC038510, DN989886
      Consensus CDS
      CCDS13022.1
      UniProtKB/Swiss-Prot
      P78324
      Related
      ENSP00000351621.4, OTTHUMP00000030001, ENST00000358771.4, OTTHUMT00000077568
      Conserved Domains (4) summary
      cd00098
      Location:266339
      IgC; Immunoglobulin Constant domain
      smart00410
      Location:41144
      IG_like; Immunoglobulin like
      pfam07686
      Location:38145
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:143254
      Ig; Immunoglobulin domain
    3. NM_001330728.1NP_001317657.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) encodes the longer protein (isoform 2).
      Source sequence(s)
      AL034562, BC026692, BC033092, DA471662, DN989886
      Consensus CDS
      CCDS82593.1
      UniProtKB/Swiss-Prot
      P78324
    4. NM_080792.2NP_542970.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_542970.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate, in-frame, splice donor site in the 3' coding region compared to variant 4. This variant encodes a shorter protein (isoform 1) compared to isoform 2. Variants 1, 2, and 3 encode the same protein (isoform 1).
      Source sequence(s)
      AB023430, AL034562
      Consensus CDS
      CCDS13022.1
      UniProtKB/Swiss-Prot
      P78324
      Related
      ENSP00000348307.3, OTTHUMP00000159968, ENST00000356025.7, OTTHUMT00000251762
      Conserved Domains (4) summary
      cd00098
      Location:266339
      IgC; Immunoglobulin Constant domain
      smart00410
      Location:41144
      IG_like; Immunoglobulin like
      pfam07686
      Location:38145
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:143254
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p7 Primary Assembly

      Range
      1894117..1939895
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005260669.3XP_005260726.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X1

      Related
      ENSP00000478763.1, OTTHUMP00000159969, ENST00000622179.4, OTTHUMT00000251763
      Conserved Domains (4) summary
      cd00098
      Location:266339
      IgC; Immunoglobulin Constant domain
      smart00410
      Location:41122
      IG_like; Immunoglobulin like
      pfam07686
      Location:38145
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:143254
      Ig; Immunoglobulin domain
    2. XM_005260670.3XP_005260727.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X1

      See identical proteins and their annotated locations for XP_005260727.1

      UniProtKB/Swiss-Prot
      P78324
      Conserved Domains (4) summary
      cd00098
      Location:266339
      IgC; Immunoglobulin Constant domain
      smart00410
      Location:41122
      IG_like; Immunoglobulin like
      pfam07686
      Location:38145
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:143254
      Ig; Immunoglobulin domain
    3. XM_006723545.3XP_006723608.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X3

      Conserved Domains (2) summary
      smart00410
      Location:41144
      IG_like; Immunoglobulin like
      pfam07686
      Location:38145
      V-set; Immunoglobulin V-set domain
    4. XM_011529173.2XP_011527475.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X2

      Conserved Domains (4) summary
      cd00098
      Location:266339
      IgC; Immunoglobulin Constant domain
      smart00410
      Location:41122
      IG_like; Immunoglobulin like
      pfam07686
      Location:38145
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:143254
      Ig; Immunoglobulin domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018931.2 Alternate CHM1_1.1

      Range
      1875015..1920758
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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