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    RAD51 RAD51 recombinase [ Homo sapiens (human) ]

    Gene ID: 5888, updated on 31-Dec-2017
    Official Symbol
    RAD51provided by HGNC
    Official Full Name
    RAD51 recombinaseprovided by HGNC
    Primary source
    HGNC:HGNC:9817
    See related
    Ensembl:ENSG00000051180 MIM:179617; Vega:OTTHUMG00000130067
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RECA; BRCC5; FANCR; MRMV2; HRAD51; RAD51A; HsRad51; HsT16930
    Summary
    The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
    Expression
    Biased expression in testis (RPKM 6.6), bone marrow (RPKM 3.5) and 13 other tissues See more
    Orthologs
    Location:
    15q15.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 15 NC_000015.10 (40694774..40732340)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (40987327..41024356)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene transfer RNA-Ser (GCT) 4-2 Neighboring gene kinetochore scaffold 1 Neighboring gene RAD51 antisense RNA 1 (head to head) Neighboring gene regulator of microtubule dynamics 3 Neighboring gene SUMO2 pseudogene 15

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Expression of Rad51 enhances basal- and HIV-1 Tat-induced transcription of the HIV-1 LTR promoter; this event requires cooperativity from the C/EBP family of transcription factors including C/EBPbeta and C/EBPbeta homologous protein (CHOP) PubMed
    tat In PC12 cells treated with genotoxic agents, HIV-1 Tat reduces DNA breakage and increases repair of DNA double-strand breaks through a mechanism involving the upregulation of Rad51, a key regulator of homologous recombination in cells PubMed
    tat HIV-1 Tat interacts with the RNA polymerase II holoenzyme, which includes HRAD51, during Tat-mediated transactivation of the HIV-1 LTR PubMed
    Vpr vpr HIV-1 Vpr inhibits the interaction of p53 and Rad51 in chromatin fractions, as observed under irradiation-induced DNA double-strand breaks PubMed
    vpr HIV-1 Vpr stimulates the focus formation of Rad51 and BRCA1, which are involved in repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) PubMed
    integrase gag-pol K133A RAD51 mutant remains to bind DNA but is unable to form an active nucleofilament due to the poor binding of ATP, which results in the defect on IN inhibition PubMed
    gag-pol RAD51 protein inhibits the integration catalyzed by HIV-1 integrase both in vitro, in yeast expressing integrase and in infected cells PubMed

    Go to the HIV-1, Human Interaction Database

    • ATM Signaling Pathway, organism-specific biosystem (from WikiPathways)
      ATM Signaling Pathway, organism-specific biosystemAtaxia-telangiectasia (A-T) is a highly pleiotropic, autosomal recessive disease that leads to multisystem defects and has an intricate cellular phenotype, all linked to the functional inactivation o...
    • BARD1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      BARD1 signaling events, organism-specific biosystem
      BARD1 signaling events
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • DNA Damage Response, organism-specific biosystem (from WikiPathways)
      DNA Damage Response, organism-specific biosystemThis is the first pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and ATR) which are connected to the sources of DNA damage (in blue). The two ...
    • DNA Double-Strand Break Repair, organism-specific biosystem (from REACTOME)
      DNA Double-Strand Break Repair, organism-specific biosystemNumerous types of DNA damage can occur within a cell due to the endogenous production of oxygen free radicals, normal alkylation reactions, or exposure to exogenous radiations and chemicals. Double-s...
    • DNA Repair, organism-specific biosystem (from REACTOME)
      DNA Repair, organism-specific biosystemDNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. Living organisms are constantly exposed to harmful metabolic by-products, enviro...
    • Fanconi anemia pathway, organism-specific biosystem (from KEGG)
      Fanconi anemia pathway, organism-specific biosystemThe Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recrui...
    • Fanconi anemia pathway, conserved biosystem (from KEGG)
      Fanconi anemia pathway, conserved biosystemThe Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recrui...
    • HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA), organism-specific biosystem (from REACTOME)
      HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA), organism-specific biosystemHomology directed repair (HDR) of replication-independent DNA double strand breaks (DSBs) via homologous recombination repair (HRR) or single strand annealing (SSA) requires the activation of ATM fol...
    • HDR through Homologous Recombination (HRR), organism-specific biosystem (from REACTOME)
      HDR through Homologous Recombination (HRR), organism-specific biosystemHomology directed repair (HDR) through homologous recombination is known as homologous recombination repair (HRR). HRR occurs after extensive resection of DNA double strand break (DSB) ends, which cr...
    • HDR through Single Strand Annealing (SSA), organism-specific biosystem (from REACTOME)
      HDR through Single Strand Annealing (SSA), organism-specific biosystemHomology directed repair (HDR) through single strand annealing (SSA), similar to HDR through homologous recombination repair (HRR), involves extensive resection of DNA double strand break ends (DSBs)...
    • Homologous DNA Pairing and Strand Exchange, organism-specific biosystem (from REACTOME)
      Homologous DNA Pairing and Strand Exchange, organism-specific biosystemThe presynaptic phase of homologous DNA pairing and strand exchange begins with the displacement of RPA from 3'-ssDNA overhangs created by extensive resection of DNA double strand break (DSB) ends. R...
    • Homologous recombination, organism-specific biosystem (from KEGG)
      Homologous recombination, organism-specific biosystemHomologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves...
    • Homologous recombination, organism-specific biosystem (from WikiPathways)
      Homologous recombination, organism-specific biosystemHomologous recombination, also known as general recombination, is a type of genetic recombination in which nucleotide sequences are exchanged between two similar or identical strands of DNA. Source:...
    • Homologous recombination, conserved biosystem (from KEGG)
      Homologous recombination, conserved biosystemHomologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves...
    • Homology Directed Repair, organism-specific biosystem (from REACTOME)
      Homology Directed Repair, organism-specific biosystemHomology directed repair (HDR) of DNA double strand breaks (DSBs) requires resection of DNA DSB ends. Resection creates 3'-ssDNA overhangs which then anneal with a homologous DNA sequence. This homol...
    • Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Breast Cancer Pathway, organism-specific biosystemThis pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Br...
    • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
    • Meiosis, organism-specific biosystem (from REACTOME)
      Meiosis, organism-specific biosystemDuring meiosis the replicated chromosomes of a single diploid cell are segregated into 4 haploid daughter cells by two successive divisions, meiosis I and meiosis II. In meiosis I, the distinguishing...
    • Meiotic recombination, organism-specific biosystem (from REACTOME)
      Meiotic recombination, organism-specific biosystemMeiotic recombination exchanges segments of duplex DNA between chromosomal homologs, generating genetic diversity (reviewed in Handel and Schimenti 2010, Inagaki et al. 2010, Cohen et al. 2006). Ther...
    • Pancreatic cancer, organism-specific biosystem (from KEGG)
      Pancreatic cancer, organism-specific biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pancreatic cancer, conserved biosystem (from KEGG)
      Pancreatic cancer, conserved biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Presynaptic phase of homologous DNA pairing and strand exchange, organism-specific biosystem (from REACTOME)
      Presynaptic phase of homologous DNA pairing and strand exchange, organism-specific biosystemThe presynaptic phase of homologous DNA pairing and strand exchange during homologous recombination repair (HRR) begins with the displacement of RPA from ssDNA (Thompson and Limoli 2003) by the joint...
    • Rac1/Pak1/p38/MMP-2 pathway, organism-specific biosystem (from WikiPathways)
      Rac1/Pak1/p38/MMP-2 pathway, organism-specific biosystemRac1/p38 pathway from Ingenuity Pathway Analysis.
    • Resolution of D-Loop Structures, organism-specific biosystem (from REACTOME)
      Resolution of D-Loop Structures, organism-specific biosystemOnce repair synthesis has occurred, the D-loop structure may be resolved either through Holliday junction intermediates or through synthesis-dependent strand-annealing (SDSA) (Prado and Aguilera 2003...
    • Resolution of D-loop Structures through Holliday Junction Intermediates, organism-specific biosystem (from REACTOME)
      Resolution of D-loop Structures through Holliday Junction Intermediates, organism-specific biosystemD-loops generated after strand invasion and DNA repair synthesis during homologous recombination repair (HRR) can be resolved through Holliday junction intermediates.A D-loop can be cleaved by the co...
    • Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA), organism-specific biosystem (from REACTOME)
      Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA), organism-specific biosystemIn the synthesis-dependent strand-annealing (SDSA) model of D-loop resolution, D-loop strands extended by DNA repair synthesis dissociate from their sister chromatid complements and reanneal with the...
    • miRNA Regulation of DNA Damage Response, organism-specific biosystem (from WikiPathways)
      miRNA Regulation of DNA Damage Response, organism-specific biosystemThis is the first out of two pathways which deals with the DNA damage response. It is comprised of two central gene products (ATM and ATR) influenced by different sources of DNA damage (in blue). The...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA polymerase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    double-stranded DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    contributes_to endodeoxyribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    four-way junction DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    recombinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    single-stranded DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    single-stranded DNA-dependent ATPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    single-stranded DNA-dependent ATPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA recombinase assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA recombination TAS
    Traceable Author Statement
    more info
    PubMed 
    DNA repair TAS
    Traceable Author Statement
    more info
    PubMed 
    DNA synthesis involved in DNA repair TAS
    Traceable Author Statement
    more info
     
    DNA unwinding involved in DNA replication IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to DNA damage stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to DNA damage stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to camptothecin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to cisplatin IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to gamma radiation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to hydroxyurea IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to ionizing radiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromosome organization involved in meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    double-strand break repair via homologous recombination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    double-strand break repair via homologous recombination TAS
    Traceable Author Statement
    more info
    PubMed 
    interstrand cross-link repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    meiotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mitotic recombination TAS
    Traceable Author Statement
    more info
    PubMed 
    mitotic recombination-dependent replication fork processing IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of G0 to G1 transition TAS
    Traceable Author Statement
    more info
     
    positive regulation of DNA ligation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homooligomerization IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    reciprocal meiotic recombination TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of double-strand break repair via homologous recombination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    replication fork processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    replication fork processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    replication-born double-strand break repair via sister chromatid exchange IEA
    Inferred from Electronic Annotation
    more info
     
    response to X-ray IEA
    Inferred from Electronic Annotation
    more info
     
    response to glucoside IEA
    Inferred from Electronic Annotation
    more info
     
    strand displacement TAS
    Traceable Author Statement
    more info
     
    strand invasion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    telomere maintenance via recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    telomere maintenance via telomere lengthening ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    PML body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    condensed chromosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    condensed nuclear chromosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    lateral element IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule organizing center IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    site of double-strand break IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    DNA repair protein RAD51 homolog 1
    Names
    BRCA1/BRCA2-containing complex, subunit 5
    RAD51 homolog A
    RecA, E. coli, homolog of
    RecA-like protein
    recombination protein A

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012120.1 RefSeqGene

      Range
      4969..41998
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001164269.1NP_001157741.1  DNA repair protein RAD51 homolog 1 isoform 2

      See identical proteins and their annotated locations for NP_001157741.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR, compared to variant 2. Both variants 2 and 4 encode the same isoform.
      Source sequence(s)
      AC012476, AK131299
      Consensus CDS
      CCDS53931.1
      UniProtKB/Swiss-Prot
      Q06609
      Related
      ENSP00000372088.3, OTTHUMP00000231941, ENST00000382643.7, OTTHUMT00000387937
      Conserved Domains (3) summary
      cd01123
      Location:116336
      Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
      TIGR02239
      Location:25340
      recomb_RAD51; DNA repair protein RAD51
      pfam14520
      Location:3277
      HHH_5; Helix-hairpin-helix domain
    2. NM_001164270.1NP_001157742.1  DNA repair protein RAD51 homolog 1 isoform 3

      See identical proteins and their annotated locations for NP_001157742.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate exon in the 5' coding region and lacks an alternate exon in the 3' coding region resulting in a frameshift, compared to variant 2. The resulting isoform (3) contains a distinct segment near the N-terminus and has a shorter and distinct C-terminus, compared to isoform 2.
      Source sequence(s)
      AC012476, D14134, EU362635
      Consensus CDS
      CCDS53932.1
      UniProtKB/Swiss-Prot
      Q06609
      Related
      ENSP00000406602.2, OTTHUMP00000231940, ENST00000423169.6, OTTHUMT00000387935
      Conserved Domains (2) summary
      cd01123
      Location:102258
      Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
      pfam14520
      Location:3280
      HHH_5; Helix-hairpin-helix domain
    3. NM_002875.4NP_002866.2  DNA repair protein RAD51 homolog 1 isoform 1

      See identical proteins and their annotated locations for NP_002866.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) uses an alternate exon in the 5' coding region, compared to variant 2. The resulting isoform (1) contains a distinct segment near the N-terminus, compared to isoform 2.
      Source sequence(s)
      AC012476, AK313503, EU362635
      Consensus CDS
      CCDS10062.1
      UniProtKB/Swiss-Prot
      Q06609
      Related
      ENSP00000267868.3, OTTHUMP00000160544, ENST00000267868.7, OTTHUMT00000252358
      Conserved Domains (1) summary
      TIGR02239
      Location:25339
      recomb_RAD51; DNA repair protein RAD51
    4. NM_133487.3NP_597994.3  DNA repair protein RAD51 homolog 1 isoform 2

      See identical proteins and their annotated locations for NP_597994.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2). Both variants 2 and 4 encode the same isoform.
      Source sequence(s)
      AC012476, AK291969, EU362635
      Consensus CDS
      CCDS53931.1
      UniProtKB/Swiss-Prot
      Q06609
      Related
      ENSP00000433924.1, OTTHUMP00000231942, ENST00000532743.5, OTTHUMT00000387938
      Conserved Domains (3) summary
      cd01123
      Location:116336
      Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
      TIGR02239
      Location:25340
      recomb_RAD51; DNA repair protein RAD51
      pfam14520
      Location:3277
      HHH_5; Helix-hairpin-helix domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p7 Primary Assembly

      Range
      40694774..40732340
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011521861.2XP_011520163.1  DNA repair protein RAD51 homolog 1 isoform X2

      See identical proteins and their annotated locations for XP_011520163.1

      UniProtKB/Swiss-Prot
      Q06609
      Conserved Domains (2) summary
      cd01123
      Location:102258
      Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
      pfam14520
      Location:3280
      HHH_5; Helix-hairpin-helix domain
    2. XM_011521857.2XP_011520159.1  DNA repair protein RAD51 homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_011520159.1

      UniProtKB/Swiss-Prot
      Q06609
      Conserved Domains (1) summary
      TIGR02239
      Location:25339
      recomb_RAD51; DNA repair protein RAD51
    3. XM_011521862.2XP_011520164.1  DNA repair protein RAD51 homolog 1 isoform X3

      Conserved Domains (2) summary
      smart00382
      Location:1182
      AAA; ATPases associated with a variety of cellular activities
      cd01123
      Location:1211
      Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
    4. XM_011521860.2XP_011520162.1  DNA repair protein RAD51 homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_011520162.1

      UniProtKB/Swiss-Prot
      Q06609
      Conserved Domains (1) summary
      TIGR02239
      Location:25339
      recomb_RAD51; DNA repair protein RAD51
    5. XM_006720626.3XP_006720689.1  DNA repair protein RAD51 homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_006720689.1

      UniProtKB/Swiss-Prot
      Q06609
      Conserved Domains (1) summary
      TIGR02239
      Location:25339
      recomb_RAD51; DNA repair protein RAD51
    6. XM_011521858.2XP_011520160.1  DNA repair protein RAD51 homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_011520160.1

      UniProtKB/Swiss-Prot
      Q06609
      Conserved Domains (1) summary
      TIGR02239
      Location:25339
      recomb_RAD51; DNA repair protein RAD51
    7. XM_011521859.2XP_011520161.1  DNA repair protein RAD51 homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_011520161.1

      UniProtKB/Swiss-Prot
      Q06609
      Conserved Domains (1) summary
      TIGR02239
      Location:25339
      recomb_RAD51; DNA repair protein RAD51

    Alternate CHM1_1.1

    Genomic

    1. NC_018926.2 Alternate CHM1_1.1

      Range
      41107382..41144356
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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