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    MPG N-methylpurine DNA glycosylase [ Homo sapiens (human) ]

    Gene ID: 4350, updated on 19-May-2018
    Official Symbol
    MPGprovided by HGNC
    Official Full Name
    N-methylpurine DNA glycosylaseprovided by HGNC
    Primary source
    HGNC:HGNC:7211
    See related
    Ensembl:ENSG00000103152 MIM:156565; Vega:OTTHUMG00000047887
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AAG; MDG; ADPG; APNG; Mid1; anpg; PIG11; PIG16; CRA36.1
    Expression
    Ubiquitous expression in prostate (RPKM 19.8), spleen (RPKM 17.9) and 25 other tissues See more
    Orthologs
    See MPG in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (77019..85851)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (127018..135850)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene small nuclear ribonucleoprotein U11/U12 subunit 25 Neighboring gene rhomboid 5 homolog 1 Neighboring gene alpha-globin locus control region Neighboring gene NPR3 like, GATOR1 complex subunit Neighboring gene hemoglobin subunit zeta Neighboring gene uncharacterized LOC107983982

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev is identified to have a physical interaction with N-methylpurine-DNA glycosylase (MPG) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    • Base Excision Repair, organism-specific biosystem (from REACTOME)
      Base Excision Repair, organism-specific biosystemOf the three major pathways involved in the repair of nucleotide damage in DNA, base excision repair (BER) involves the greatest number of individual enzymatic activities. This is the consequence of ...
    • Base excision repair, organism-specific biosystem (from KEGG)
      Base excision repair, organism-specific biosystemBase excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair ...
    • Base excision repair, conserved biosystem (from KEGG)
      Base excision repair, conserved biosystemBase excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair ...
    • Base-Excision Repair, AP Site Formation, organism-specific biosystem (from REACTOME)
      Base-Excision Repair, AP Site Formation, organism-specific biosystemBase excision repair is initiated by DNA glycosylases that hydrolytically cleave the base-deoxyribose glycosyl bond of a damaged nucleotide residue, releasing the damaged base (Lindahl and Wood 1999,...
    • Cleavage of the damaged purine, organism-specific biosystem (from REACTOME)
      Cleavage of the damaged purine, organism-specific biosystemDamaged purines are cleaved from the sugar-phosphate backbone by purine-specific glycosylases (Saparbaev and Laval 1994, Lindahl and Wood 1999).
    • DNA Repair, organism-specific biosystem (from REACTOME)
      DNA Repair, organism-specific biosystemDNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. Living organisms are constantly exposed to harmful metabolic by-products, enviro...
    • Depurination, organism-specific biosystem (from REACTOME)
      Depurination, organism-specific biosystemDepurination of a damaged nucleotide is mediated by a purine-specific DNA glycosylase. The glycosylase cleaves the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, genera...
    • Displacement of DNA glycosylase by APEX1, organism-specific biosystem (from REACTOME)
      Displacement of DNA glycosylase by APEX1, organism-specific biosystemFollowing cleavage of the damaged base, DNA glycosylase is displaced by APEX1, an AP endonuclease (Parikh et al. 1998).
    • Recognition and association of DNA glycosylase with site containing an affected purine, organism-specific biosystem (from REACTOME)
      Recognition and association of DNA glycosylase with site containing an affected purine, organism-specific biosystemThe recognition and removal of an altered base by a DNA glycosylase is thought to involve the diffusion of the enzyme along the minor grove of the DNA molecule. The enzyme presumably compresses the ...
    • Resolution of Abasic Sites (AP sites), organism-specific biosystem (from REACTOME)
      Resolution of Abasic Sites (AP sites), organism-specific biosystemResolution of AP sites can occur through the single nucleotide replacement pathway or through the multiple nucleotide patch replacement pathway, also known as the long-patch base excision repair (BER...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA N-glycosylase activity TAS
    Traceable Author Statement
    more info
     
    DNA-3-methyladenine glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-3-methylguanine glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-7-methyladenine glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-7-methylguanine glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    alkylbase DNA N-glycosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    damaged DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA dealkylation involved in DNA repair TAS
    Traceable Author Statement
    more info
    PubMed 
    base-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    base-excision repair TAS
    Traceable Author Statement
    more info
    PubMed 
    depurination TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    mitochondrial nucleoid IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    DNA-3-methyladenine glycosylase
    Names
    3' end of the Mid1 gene, localized 68 kb upstream the humanzeta globin gene on 16p
    3-alkyladenine DNA glycosylase
    3-methyladenine DNA glycosidase
    CRA36.1 (3-methyl-adenine DNA glycosylase)
    N-methylpurine-DNA glycosylase, MPG
    proliferation-inducing protein 11
    proliferation-inducing protein 16
    NP_001015052.1
    NP_001015054.1
    NP_002425.2
    XP_024306050.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001015052.2NP_001015052.1  DNA-3-methyladenine glycosylase isoform b

      See identical proteins and their annotated locations for NP_001015052.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) is shorter and has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AW083039, BC014991, BM796301
      Consensus CDS
      CCDS32345.1
      UniProtKB/Swiss-Prot
      P29372
      Related
      ENSP00000348809.3, OTTHUMP00000067137, ENST00000356432.7, OTTHUMT00000134172
      Conserved Domains (1) summary
      cd00540
      Location:85281
      AAG; Alkyladenine DNA glycosylase catalyzes the first step in base excision repair
    2. NM_001015054.2NP_001015054.1  DNA-3-methyladenine glycosylase isoform c

      See identical proteins and their annotated locations for NP_001015054.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AW083039, AY258284, BG823448
      Consensus CDS
      CCDS42087.1
      UniProtKB/Swiss-Prot
      P29372
      Related
      ENSP00000380918.1, ENST00000397817.5
      Conserved Domains (1) summary
      cd00540
      Location:73269
      AAG; Alkyladenine DNA glycosylase catalyzes the first step in base excision repair
    3. NM_002434.3NP_002425.2  DNA-3-methyladenine glycosylase isoform a

      See identical proteins and their annotated locations for NP_002425.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AL520052, AW083039, AY258284, BM796301
      Consensus CDS
      CCDS32346.1
      UniProtKB/Swiss-Prot
      P29372
      UniProtKB/TrEMBL
      Q1W6H1
      Related
      ENSP00000219431.4, OTTHUMP00000045554, ENST00000219431.4, OTTHUMT00000109121
      Conserved Domains (1) summary
      cd00540
      Location:90286
      AAG; Alkyladenine DNA glycosylase catalyzes the first step in base excision repair

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

      Range
      77019..85851
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024450282.1XP_024306050.1  DNA-3-methyladenine glycosylase isoform X1

      Conserved Domains (1) summary
      cd00540
      Location:90286
      AAG; Alkyladenine DNA glycosylase catalyzes the first step in base excision repair
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