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    THY1 Thy-1 cell surface antigen [ Homo sapiens (human) ]

    Gene ID: 7070, updated on 23-May-2018
    Official Symbol
    THY1provided by HGNC
    Official Full Name
    Thy-1 cell surface antigenprovided by HGNC
    Primary source
    HGNC:HGNC:11801
    See related
    Ensembl:ENSG00000154096 MIM:188230; Vega:OTTHUMG00000166202
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD90; CDw90
    Summary
    This gene encodes a cell surface glycoprotein and member of the immunoglobulin superfamily of proteins. The encoded protein is involved in cell adhesion and cell communication in numerous cell types, but particularly in cells of the immune and nervous systems. The encoded protein is widely used as a marker for hematopoietic stem cells. This gene may function as a tumor suppressor in nasopharyngeal carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
    Expression
    Broad expression in brain (RPKM 87.8), kidney (RPKM 58.0) and 16 other tissues See more
    Orthologs
    See THY1 in Genome Data Viewer
    Location:
    11q23.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (119417941..119424985, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (119288655..119294246, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene HNF4 motif-containing MPRA enhancer 223 Neighboring gene ubiquitin specific peptidase 2 Neighboring gene USP2 antisense RNA 1 (head to head) Neighboring gene major facilitator superfamily domain containing 14B pseudogene Neighboring gene double homeobox A pseudogene 5 Neighboring gene uncharacterized LOC107984398

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag HIV Gag proteins adopt a ring-like supramolecular organization at sites of intercellular contacts and co-localize with CD63 tetraspanin and raft components GM1, Thy-1, and CD59 PubMed
    gag The Matrix protein of HIV-1 Gag co-localizes with Thy-1 in lipid rafts, the site of virus particle budding from cells, and Thy-1 is incorporated into virus particles as a result of this process PubMed
    matrix gag HIV-1 Matrix co-localizes with Thy-1 in lipid rafts, the site of virus particle budding from cells, and Thy-1 is incorporated into virus particles as a result of this process PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ33325

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GPI anchor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    GPI anchor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integrin binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    integrin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    T cell receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell-cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell-cell signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    focal adhesion assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    focal adhesion assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    integrin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of T cell receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of axonogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of neuron projection regeneration ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    negative regulation of protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of protein tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of T cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of T cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cellular extravasation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of focal adhesion assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of heterotypic cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of release of sequestered calcium ion into cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of release of sequestered calcium ion into cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    receptor clustering ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of Rho-dependent protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    regulation of cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retinal cone cell development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    retinal cone cell development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    anchored component of external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axolemma ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    dendrite membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
     
    external side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    extracellular exosome HDA PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    focal adhesion HDA PubMed 
    growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    membrane raft IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    membrane raft NAS
    Non-traceable Author Statement
    more info
    PubMed 
    myelin sheath IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuronal cell body membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    thy-1 membrane glycoprotein
    Names
    Thy-1 T-cell antigen
    thy-1 antigen

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311160.1NP_001298089.1  thy-1 membrane glycoprotein preproprotein

      See identical proteins and their annotated locations for NP_001298089.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AK090644, AK090996, AP003396, BC065559, BE672723, BM504140
      Consensus CDS
      CCDS8424.1
      UniProtKB/Swiss-Prot
      P04216
      UniProtKB/TrEMBL
      B0YJA4
      Related
      ENSP00000431301.1, OTTHUMP00000232164, ENST00000528522.5, OTTHUMT00000388372
      Conserved Domains (1) summary
      pfam00047
      Location:21117
      ig; Immunoglobulin domain
    2. NM_001311162.1NP_001298091.1  thy-1 membrane glycoprotein preproprotein

      See identical proteins and their annotated locations for NP_001298091.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AK090996, AP003396, BC065559, BE672723, BM504140, DA063412
      Consensus CDS
      CCDS8424.1
      UniProtKB/Swiss-Prot
      P04216
      UniProtKB/TrEMBL
      B0YJA4
      Related
      ENSP00000435753.1, OTTHUMP00000232168, ENST00000524659.1, OTTHUMT00000388376
      Conserved Domains (1) summary
      pfam00047
      Location:21117
      ig; Immunoglobulin domain
    3. NM_006288.4NP_006279.2  thy-1 membrane glycoprotein preproprotein

      See identical proteins and their annotated locations for NP_006279.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
      Source sequence(s)
      AK090996, BC065559, BE672723, BM504140
      Consensus CDS
      CCDS8424.1
      UniProtKB/Swiss-Prot
      P04216
      UniProtKB/TrEMBL
      B0YJA4
      Related
      ENSP00000284240.5, OTTHUMP00000232162, ENST00000284240.9, OTTHUMT00000388370
      Conserved Domains (1) summary
      pfam00047
      Location:21117
      ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

      Range
      119417941..119424985 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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