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    MYLK myosin light chain kinase [ Gallus gallus (chicken) ]

    Gene ID: 396445, updated on 12-Mar-2017
    Symbol
    MYLKprovided by CGNC
    Full Name
    myosin light chain kinaseprovided by CGNC
    Primary source
    CGNC:8898
    See related
    Ensembl:ENSGALG00000011708
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    MLCK
    Orthologs
    Location:
    chromosome: 7
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    103 current Gallus_gallus-5.0 (GCF_000002315.4) 7 NC_006094.4 (27324149..27507722, complement)
    102 previous assembly Gallus_gallus-4.0 (GCF_000002315.3) 7 NC_006094.3 (26676887..26805324, complement)

    Chromosome 7 - NC_006094.4Genomic Context describing neighboring genes Neighboring gene adenylate cyclase 5 Neighboring gene uncharacterized LOC107053877 Neighboring gene uncharacterized LOC107053879 Neighboring gene 3-hydroxyacyl-CoA dehydratase 2 Neighboring gene uncharacterized LOC107053878 Neighboring gene coiled-coil domain containing 14 Neighboring gene kalirin, RhoGEF kinase

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Apelin signaling pathway, organism-specific biosystem (from KEGG)
      Apelin signaling pathway, organism-specific biosystemApelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various ti...
    • Calcium signaling pathway, organism-specific biosystem (from KEGG)
      Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Calcium signaling pathway, conserved biosystem (from KEGG)
      Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
      Regulation of Actin Cytoskeleton, organism-specific biosystem
      Regulation of Actin Cytoskeleton
    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton
    • Vascular smooth muscle contraction, organism-specific biosystem (from KEGG)
      Vascular smooth muscle contraction, organism-specific biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
    • Vascular smooth muscle contraction, conserved biosystem (from KEGG)
      Vascular smooth muscle contraction, conserved biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    myosin light chain kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    smooth muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    myosin light chain kinase, smooth muscle
    Names
    kinase related protein
    myosin, light polypeptide kinase
    smooth muscle myosin light chain kinase (61-kDa active fragment)
    telokin
    NP_990790.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001322361.1NP_001309290.1  myosin light chain kinase, smooth muscle isoform 1

      Status: VALIDATED

      Source sequence(s)
      AADN04023946
      UniProtKB/TrEMBL
      A0A1L1RRF3
      Conserved Domains (9) summary
      cd00096
      Location:102172
      Ig; Immunoglobulin domain
      cd05762
      Location:12831379
      Ig8_MLCK; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK)
      smart00408
      Location:18641931
      IGc2; Immunoglobulin C-2 Type
      cd00063
      Location:13751466
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:18511941
      I-set; Immunoglobulin I-set domain
      cd14191
      Location:15071765
      STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
      pfam00069
      Location:15101765
      Pkinase; Protein kinase domain
      pfam16620
      Location:313482
      23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
      cl11960
      Location:212301
      Ig; Immunoglobulin domain
    2. NM_205459.3NP_990790.2  myosin light chain kinase, smooth muscle isoform 2

      Status: VALIDATED

      Source sequence(s)
      AADN04023946
      UniProtKB/TrEMBL
      E1C906
      Related
      ENSGALP00000037183, ENSGALT00000037978
      Conserved Domains (9) summary
      cd00096
      Location:45115
      Ig; Immunoglobulin domain
      cd05762
      Location:12261322
      Ig8_MLCK; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK)
      smart00408
      Location:18071874
      IGc2; Immunoglobulin C-2 Type
      cd00063
      Location:13181409
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:17941884
      I-set; Immunoglobulin I-set domain
      cd14191
      Location:14501708
      STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
      pfam00069
      Location:14531708
      Pkinase; Protein kinase domain
      pfam16620
      Location:256425
      23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
      cl11960
      Location:155244
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Gallus_gallus-5.0 Primary Assembly

    Genomic

    1. NC_006094.4 Reference Gallus_gallus-5.0 Primary Assembly

      Range
      27324149..27507722 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015289793.1XP_015145279.1  myosin light chain kinase, smooth muscle isoform X1

      Related
      ENSGALP00000061379, ENSGALT00000089896
      Conserved Domains (9) summary
      cd00096
      Location:102172
      Ig; Immunoglobulin domain
      cd05762
      Location:12831379
      Ig8_MLCK; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK)
      smart00408
      Location:18641931
      IGc2; Immunoglobulin C-2 Type
      cd00063
      Location:13751466
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:18511941
      I-set; Immunoglobulin I-set domain
      cd14191
      Location:15071765
      STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
      pfam00069
      Location:15101765
      Pkinase; Protein kinase domain
      pfam16620
      Location:313482
      23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
      cl11960
      Location:212301
      Ig; Immunoglobulin domain
    2. XM_015289794.1XP_015145280.1  myosin light chain kinase, smooth muscle isoform X2

      UniProtKB/Swiss-Prot
      P11799
      Conserved Domains (2) summary
      smart00408
      Location:58125
      IGc2; Immunoglobulin C-2 Type
      pfam07679
      Location:45135
      I-set; Immunoglobulin I-set domain
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