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    SCGB1A1 secretoglobin family 1A member 1 [ Homo sapiens (human) ]

    Gene ID: 7356, updated on 6-Aug-2017
    Official Symbol
    SCGB1A1provided by HGNC
    Official Full Name
    secretoglobin family 1A member 1provided by HGNC
    Primary source
    HGNC:HGNC:12523
    See related
    Ensembl:ENSG00000149021 MIM:192020; Vega:OTTHUMG00000167526
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UGB; UP1; CC10; CC16; CCSP; UP-1; CCPBP
    Summary
    This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. Defects in this gene are associated with a susceptibility to asthma. [provided by RefSeq, May 2010]
    Orthologs
    Location:
    11q12.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 11 NC_000011.10 (62419035..62423206)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62186507..62190678)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene asparaginase like 1 Neighboring gene regulator of chromosome condensation 2 pseudogene 6 Neighboring gene uncharacterized LOC107984335 Neighboring gene uncharacterized LOC102723765 Neighboring gene AHNAK nucleoprotein Neighboring gene eukaryotic translation elongation factor 1 gamma Neighboring gene microRNA 6747

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    phospholipase A2 inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    polychlorinated biphenyl binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    embryo implantation TAS
    Traceable Author Statement
    more info
    PubMed 
    female pregnancy NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of interferon-gamma production IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of interleukin-13 production IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of interleukin-4 production IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of interleukin-5 production IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of mRNA stability IEA
    Inferred from Electronic Annotation
    more info
     
    response to cytokine IEA
    Inferred from Electronic Annotation
    more info
     
    response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    response to fibroblast growth factor IEA
    Inferred from Electronic Annotation
    more info
     
    response to glucocorticoid IEA
    Inferred from Electronic Annotation
    more info
     
    response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    response to ozone IEA
    Inferred from Electronic Annotation
    more info
     
    response to silicon dioxide IEA
    Inferred from Electronic Annotation
    more info
     
    response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
     
    rough endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    secretory granule IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    uteroglobin
    Names
    blastokinin
    clara cell phospholipid-binding protein
    clara cells 10 kDa secretory protein
    secretoglobin, family 1A, member 1 (uteroglobin)
    urinary protein 1
    urine protein 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021331.1 RefSeqGene

      Range
      5001..9172
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003357.4NP_003348.1  uteroglobin precursor

      See identical proteins and their annotated locations for NP_003348.1

      Status: REVIEWED

      Source sequence(s)
      AK312165, AP003064, BC004481, DB196705
      Consensus CDS
      CCDS8020.1
      UniProtKB/Swiss-Prot
      P11684
      UniProtKB/TrEMBL
      A0A0S2Z4R6
      Related
      ENSP00000278282.2, OTTHUMP00000236107, ENST00000278282.2, OTTHUMT00000394925
      Conserved Domains (1) summary
      smart00096
      Location:2290
      UTG; Uteroglobin

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p7 Primary Assembly

      Range
      62419035..62423206
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      62069549..62073720
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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