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    Vcp valosin containing protein [ Mus musculus (house mouse) ]

    Gene ID: 269523, updated on 6-Aug-2017
    Official Symbol
    Vcpprovided by MGI
    Official Full Name
    valosin containing proteinprovided by MGI
    Primary source
    MGI:MGI:99919
    See related
    Ensembl:ENSMUSG00000028452 Vega:OTTMUSG00000006688
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p97; CDC48; p97/VCP; 3110001E05
    Orthologs
    Location:
    4 A5; 4 22.95 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (42979964..43000507, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (42992836..43013379, complement)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member B5 Neighboring gene RIKEN cDNA 1700022I11 gene Neighboring gene Fanconi anemia, complementation group G Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class O Neighboring gene stomatin (Epb7.2)-like 2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ADP binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ADP binding ISO
    Inferred from Sequence Orthology
    more info
     
    ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ATP binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    ATPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    BAT3 complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    K48-linked polyubiquitin modification-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    MHC class I protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    deubiquitinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    polyubiquitin modification-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-like protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-specific protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin-specific protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    ATP metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    ER to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    ER-associated misfolded protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
     
    NADH metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    aggresome assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    autophagosome maturation ISO
    Inferred from Sequence Orthology
    more info
     
    autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum stress-induced pre-emptive quality control ISO
    Inferred from Sequence Orthology
    more info
     
    endosome to lysosome transport via multivesicular body sorting pathway ISO
    Inferred from Sequence Orthology
    more info
     
    flavin adenine dinucleotide catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    macroautophagy ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ATP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of Lys63-specific deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitochondrial membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of oxidative phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein K63-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein N-linked glycosylation via asparagine ISO
    Inferred from Sequence Orthology
    more info
     
    protein hexamerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein hexamerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein hexamerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of aerobic respiration ISO
    Inferred from Sequence Orthology
    more info
     
    retrograde protein transport, ER to cytosol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retrograde protein transport, ER to cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    translesion synthesis ISO
    Inferred from Sequence Orthology
    more info
     
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-dependent ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-dependent protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    ATPase complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Derlin-1 retrotranslocation complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Derlin-1 retrotranslocation complex ISO
    Inferred from Sequence Orthology
    more info
     
    VCP-NPL4-UFD1 AAA ATPase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    VCP-NPL4-UFD1 AAA ATPase complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    VCP-NPL4-UFD1 AAA ATPase complex ISO
    Inferred from Sequence Orthology
    more info
     
    VCP-NSFL1C complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    VCP-NSFL1C complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    lipid droplet ISO
    Inferred from Sequence Orthology
    more info
     
    myelin sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    proteasome complex ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    transitional endoplasmic reticulum ATPase
    Names
    15S Mg(2+)-ATPase p97 subunit
    AAA ATPase p97
    Inv protein
    TER ATPase
    homolog of yeast cdc48
    NP_033529.3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009503.4NP_033529.3  transitional endoplasmic reticulum ATPase

      See identical proteins and their annotated locations for NP_033529.3

      Status: VALIDATED

      Source sequence(s)
      AK153249, BY732145
      Consensus CDS
      CCDS18086.1
      UniProtKB/Swiss-Prot
      Q01853
      Related
      ENSMUSP00000030164.7, OTTMUSP00000007079, ENSMUST00000030164.7, OTTMUST00000015330
      Conserved Domains (6) summary
      smart01072
      Location:131191
      CDC48_2; Cell division protein 48 (CDC48) domain 2
      TIGR01243
      Location:25764
      CDC48; AAA family ATPase, CDC48 subfamily
      pfam00004
      Location:241370
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam02359
      Location:25107
      CDC48_N; Cell division protein 48 (CDC48), N-terminal domain
      pfam09336
      Location:718760
      Vps4_C; Vps4 C terminal oligomerization domain
      cl21455
      Location:452534
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      42979964..43000507 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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