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    NECTIN2 nectin cell adhesion molecule 2 [ Homo sapiens (human) ]

    Gene ID: 5819, updated on 12-Mar-2017
    Official Symbol
    NECTIN2provided by HGNC
    Official Full Name
    nectin cell adhesion molecule 2provided by HGNC
    Primary source
    HGNC:HGNC:9707
    See related
    Ensembl:ENSG00000130202 MIM:600798; Vega:OTTHUMG00000180839
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HVEB; PRR2; CD112; PVRL2; PVRR2
    Summary
    This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    19q13.32
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 19 NC_000019.10 (44846136..44889228)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (45349393..45392485)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Cbl proto-oncogene C Neighboring gene basal cell adhesion molecule (Lutheran blood group) Neighboring gene translocase of outer mitochondrial membrane 40 Neighboring gene apolipoprotein E

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A comprehensive genetic association study of Alzheimer disease in African Americans.
    NHGRI GWA Catalog
    A genome-wide association study for late-onset Alzheimer's disease using DNA pooling.
    NHGRI GWA Catalog
    APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study.
    NHGRI GWA Catalog
    Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities.
    NHGRI GWA Catalog
    Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.
    NHGRI GWA Catalog
    Genome-wide association analysis of age-at-onset in Alzheimer's disease.
    NHGRI GWA Catalog
    Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis.
    NHGRI GWA Catalog
    Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.
    NHGRI GWA Catalog
    Overrepresentation of glutamate signaling in Alzheimer's disease: network-based pathway enrichment using meta-analysis of genome-wide association studies.
    NHGRI GWA Catalog
    SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians.
    NHGRI GWA Catalog
    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Adherens junction, organism-specific biosystem (from KEGG)
      Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Adherens junction, conserved biosystem (from KEGG)
      Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Adherens junctions interactions, organism-specific biosystem (from REACTOME)
      Adherens junctions interactions, organism-specific biosystemThe adherens junctions (AJ) are multiprotein complexes that promote homotypic cell adhesion in nearly all types of tissue by linking membrane and cytoskeletal components at discrete contact regions (...
    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell junction organization, organism-specific biosystem (from REACTOME)
      Cell junction organization, organism-specific biosystem
      Cell junction organization
    • Cell-Cell communication, organism-specific biosystem (from REACTOME)
      Cell-Cell communication, organism-specific biosystemCell-to-Cell communication is crucial for multicellular organisms because it allows organisms to coordinate the activity of their cells. Some cell-to-cell communication requires direct cell-cell cont...
    • Cell-cell junction organization, organism-specific biosystem (from REACTOME)
      Cell-cell junction organization, organism-specific biosystemEpithelial cell-cell contacts consist of three major adhesion systems: adherens junctions (AJs), tight junctions (TJs), and desmosomes. These adhesion systems differ in their function and compositio...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
      Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
    • Monoamine Transport, organism-specific biosystem (from WikiPathways)
      Monoamine Transport, organism-specific biosystem
      Monoamine Transport
    • Nectin adhesion pathway, organism-specific biosystem (from Pathway Interaction Database)
      Nectin adhesion pathway, organism-specific biosystem
      Nectin adhesion pathway
    • Nectin/Necl trans heterodimerization, organism-specific biosystem (from REACTOME)
      Nectin/Necl trans heterodimerization, organism-specific biosystemNectins and Nectin-like molecules (Necls) also undergo trans-heterophilic interactions to interact with other nectin or Necl family members. Besides these trans interactions among nectins and nectin-...
    • Stabilization and expansion of the E-cadherin adherens junction, organism-specific biosystem (from Pathway Interaction Database)
      Stabilization and expansion of the E-cadherin adherens junction, organism-specific biosystem
      Stabilization and expansion of the E-cadherin adherens junction
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cell adhesion molecule binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    coreceptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    virus receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acrosome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    adherens junction organization TAS
    Traceable Author Statement
    more info
     
    adhesion of symbiont to host IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell part morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    cell recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cilium organization IEA
    Inferred from Electronic Annotation
    more info
     
    coreceptor-mediated virion attachment to host cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    establishment of mitochondrion localization IEA
    Inferred from Electronic Annotation
    more info
     
    fertilization IEA
    Inferred from Electronic Annotation
    more info
     
    fusion of virus membrane with host plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    homophilic cell adhesion via plasma membrane adhesion molecules IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of immunoglobulin mediated immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of mast cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of natural killer cell mediated cytotoxicity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of immune response TAS
    Traceable Author Statement
    more info
     
    regulation of viral entry into host cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    sperm mitochondrion organization IEA
    Inferred from Electronic Annotation
    more info
     
    spermatid development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    spermatid nucleus differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    susceptibility to T cell mediated cytotoxicity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    susceptibility to natural killer cell mediated cytotoxicity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cell-cell contact zone IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    zonula adherens ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Preferred Names
    nectin-2
    Names
    herpesvirus entry protein B
    poliovirus receptor-like 2
    poliovirus receptor-related 2 (herpesvirus entry mediator B)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029149.1 RefSeqGene

      Range
      5001..48093
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001042724.1NP_001036189.1  nectin-2 isoform delta precursor

      See identical proteins and their annotated locations for NP_001036189.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (delta) represents the longer transcript and encodes the longer isoform (delta).
      Source sequence(s)
      AJ708439, CN359643, CN410857, DA198252, X80038
      Consensus CDS
      CCDS42576.1
      UniProtKB/Swiss-Prot
      Q92692
      Related
      ENSP00000252483, OTTHUMP00000265440, ENST00000252483, OTTHUMT00000453231
      Conserved Domains (3) summary
      smart00410
      Location:40158
      IG_like; Immunoglobulin like
      pfam13927
      Location:280333
      Ig_3; Immunoglobulin domain
      cl11960
      Location:162257
      Ig; Immunoglobulin domain
    2. NM_002856.2NP_002847.1  nectin-2 isoform alpha precursor

      See identical proteins and their annotated locations for NP_002847.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (alpha) has multiple differences in the coding region, compared to variant delta, one of which results in an early stop codon. The resulting protein (isoform alpha) has a distinct C-terminus and is shorter than isoform delta.
      Source sequence(s)
      AF058448, BQ549399, DA198252
      Consensus CDS
      CCDS12645.1
      UniProtKB/Swiss-Prot
      Q92692
      Related
      ENSP00000252485, OTTHUMP00000265439, ENST00000252485, OTTHUMT00000453230
      Conserved Domains (3) summary
      smart00410
      Location:40158
      IG_like; Immunoglobulin like
      pfam13927
      Location:280333
      Ig_3; Immunoglobulin domain
      cl11960
      Location:162257
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p7 Primary Assembly

      Range
      44846136..44889228
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011527192.2XP_011525494.1  nectin-2 isoform X1

      Conserved Domains (3) summary
      smart00410
      Location:40158
      IG_like; Immunoglobulin like
      pfam13927
      Location:280333
      Ig_3; Immunoglobulin domain
      cl11960
      Location:162257
      Ig; Immunoglobulin domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018930.2 Alternate CHM1_1.1

      Range
      45352150..45395259
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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