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    Pebp1 phosphatidylethanolamine binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29542, updated on 4-Jun-2017
    Official Symbol
    Pebp1provided by RGD
    Official Full Name
    phosphatidylethanolamine binding protein 1provided by RGD
    Primary source
    RGD:62017
    See related
    Ensembl:ENSRNOG00000001136
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pbp; HCNP; Rkip
    Summary
    lipid binding protein; enhances acetylcholine synthesis in medial septal regions; human homolog (RKIP) has been shown to inhibit MEK- and ERK- signalling pathways [RGD, Feb 2006]
    Orthologs
    Location:
    12q16
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (45026948..45031148)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 12 NC_005111.3 (46846901..46851101)

    Chromosome 12 - NC_005111.4Genomic Context describing neighboring genes Neighboring gene WD repeat and SOCS box-containing 2 Neighboring gene V-set and immunoglobulin domain containing 10 Neighboring gene TAO kinase 3 Neighboring gene SDS3 homolog, SIN3A corepressor complex component

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    lipid binding TAS
    Traceable Author Statement
    more info
    PubMed 
    mitogen-activated protein kinase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    aging IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    eating behavior IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    hippocampus development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    negative regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of acetylcholine metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cAMP-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of mitotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of neurotransmitter levels IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of the force of heart contraction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to activity IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to cAMP IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to calcium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to corticosterone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to electrical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to heat IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organic substance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organonitrogen compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to oxidative stress IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to toxic substance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to wounding IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    sperm capacitation IEA
    Inferred from Electronic Annotation
    more info
     
    sperm capacitation ISO
    Inferred from Sequence Orthology
    more info
     
    spermatid development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    spermatid development TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon terminus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myelin sheath IEA
    Inferred from Electronic Annotation
    more info
     
    myelin sheath ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    rough endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    phosphatidylethanolamine-binding protein 1
    Names
    23 kDa morphine-binding protein
    HCNPpp
    P23K
    PEBP-1
    Raf-1 kinase inhibitor protein
    hippocampal cholinergic neurostimulating peptide

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017236.1NP_058932.1  phosphatidylethanolamine-binding protein 1

      See identical proteins and their annotated locations for NP_058932.1

      Status: PROVISIONAL

      Source sequence(s)
      X75253
      UniProtKB/Swiss-Prot
      P31044
      Related
      ENSRNOP00000001500.3, ENSRNOT00000001500.6
      Conserved Domains (1) summary
      cd00866
      Location:25171
      PEBP_euk; PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005111.4 Reference Rnor_6.0 Primary Assembly

      Range
      45026948..45031148
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000080.1 Alternate Rn_Celera

      Range
      40944260..40948460
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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