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    SLC5A10 solute carrier family 5 member 10 [ Homo sapiens (human) ]

    Gene ID: 125206, updated on 6-Sep-2017
    Official Symbol
    SLC5A10provided by HGNC
    Official Full Name
    solute carrier family 5 member 10provided by HGNC
    Primary source
    HGNC:HGNC:23155
    See related
    Ensembl:ENSG00000154025 Vega:OTTHUMG00000178143
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SGLT5; SGLT-5
    Summary
    This gene is a member of the sodium/glucose transporter family. Members of this family are sodium-dependent transporters and can be divided into two subfamilies based on sequence homology, one that co-transports sugars and the second that transports molecules such as ascorbate, choline, iodide, lipoate, monocaroboxylates, and pantothenate. The protein encoded by this gene has the highest affinity for mannose and has been reported to be most highly expressed in the kidney. This protein may function as a kidney-specific, sodium-dependent mannose and fructose co-transporter. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
    Expression
    Biased expression in kidney (RPKM 27.8), skin (RPKM 6.0) and 1 other tissue See more
    Orthologs
    Location:
    17p11.2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 17 NC_000017.11 (18950676..19020691)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (18853989..18924004)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene coiled-coil domain-containing protein 144B-like Neighboring gene RNA, 7SL, cytoplasmic 627, pseudogene Neighboring gene phosphoribosyl pyrophosphate synthetase associated protein 2 Neighboring gene RAN binding protein 1 pseudogene Neighboring gene family with sequence similarity 83 member G Neighboring gene GRB2-related adaptor protein Neighboring gene small nucleolar RNA, C/D box 3B-1 Neighboring gene small nucleolar RNA, C/D box 3B-2

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Hexose transport, organism-specific biosystem (from REACTOME)
      Hexose transport, organism-specific biosystemHexoses, notably fructose, glucose, and galactose, generated in the lumen of the small intestine by breakdown of dietary carbohydrate are taken up by enterocytes lining the microvilli of the small in...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of carbohydrates, organism-specific biosystem (from REACTOME)
      Metabolism of carbohydrates, organism-specific biosystemThese pathways together are responsible for: 1) the extraction of energy and carbon skeletons for biosyntheses from dietary sugars and related molecules; 2) the short-term storage of glucose in the b...
    • NRF2 pathway, organism-specific biosystem (from WikiPathways)
      NRF2 pathway, organism-specific biosystemNRF2 is part of a group of transcription factors called nuclear receptors. It is activated under oxidative stress conditions and subsequently activates several antioxidative genes and proteins.
    • SLC-mediated transmembrane transport, organism-specific biosystem (from REACTOME)
      SLC-mediated transmembrane transport, organism-specific biosystemProteins with transporting functions can be roughly classified into 3 categories: ATP-powered pumps, ion channels, and transporters. Pumps utilize the energy released by ATP hydrolysis to power the m...
    • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
      Transmembrane transport of small molecules, organism-specific biosystem
      Transmembrane transport of small molecules

    Markers

    Homology

    Clone Names

    • FLJ25217

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    glucose:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    solute:sodium symporter activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    glucose transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    hexose transport TAS
    Traceable Author Statement
    more info
     
    sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    sodium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    sodium/glucose cotransporter 5
    Names
    Na(+)/glucose cotransporter 5
    solute carrier family 5 (sodium/glucose cotransporter), member 10
    solute carrier family 5 (sodium/sugar cotransporter), member 10

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042450.2NP_001035915.1  sodium/glucose cotransporter 5 isoform 2

      See identical proteins and their annotated locations for NP_001035915.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AA745934, BC034380, BP332461, DR003789
      Consensus CDS
      CCDS42275.1
      UniProtKB/Swiss-Prot
      A0PJK1
      Related
      ENSP00000379007.3, OTTHUMP00000065730, ENST00000395645.3, OTTHUMT00000132129
      Conserved Domains (1) summary
      cd11489
      Location:17596
      SLC5sbd_SGLT5; Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain
    2. NM_001270648.1NP_001257577.1  sodium/glucose cotransporter 5 isoform 3

      See identical proteins and their annotated locations for NP_001257577.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AA745934, BC062617, BP332461
      Consensus CDS
      CCDS59278.1
      UniProtKB/Swiss-Prot
      A0PJK1
      Related
      ENSP00000379005.2, OTTHUMP00000065731, ENST00000395643.6, OTTHUMT00000132130
      Conserved Domains (1) summary
      cl00456
      Location:17569
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    3. NM_001270649.1NP_001257578.1  sodium/glucose cotransporter 5 isoform 4

      See identical proteins and their annotated locations for NP_001257578.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
      Source sequence(s)
      AA745934, AK298345, BC062617, BP332461, DR003789
      Consensus CDS
      CCDS59277.1
      UniProtKB/Swiss-Prot
      A0PJK1
      Related
      ENSP00000401875.2, ENST00000417251.6
      Conserved Domains (1) summary
      cl00456
      Location:17560
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    4. NM_001282417.1NP_001269346.1  sodium/glucose cotransporter 5 isoform 5

      See identical proteins and their annotated locations for NP_001269346.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and has many differences in the coding region but maintains the reading frame compared to variant 1. This variant encodes isoform 5, which has a shorter N-terminus and is shorter compared to isoform 1.
      Source sequence(s)
      AA745934, BC034380, BC039868
      Consensus CDS
      CCDS74008.1
      UniProtKB/Swiss-Prot
      A0PJK1
      Related
      ENSP00000324346.6, OTTHUMP00000065732, ENST00000317977.10, OTTHUMT00000132131
      Conserved Domains (1) summary
      cl00456
      Location:1566
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    5. NM_152351.4NP_689564.3  sodium/glucose cotransporter 5 isoform 1

      See identical proteins and their annotated locations for NP_689564.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AA745934, AK057946, BC034380
      Consensus CDS
      CCDS11201.2
      UniProtKB/Swiss-Prot
      A0PJK1
      Related
      ENSP00000379008.2, OTTHUMP00000065729, ENST00000395647.6, OTTHUMT00000132128
      Conserved Domains (1) summary
      cd11489
      Location:17612
      SLC5sbd_SGLT5; Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p7 Primary Assembly

      Range
      18950676..19020691
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011523653.2XP_011521955.1  sodium/glucose cotransporter 5 isoform X3

      Conserved Domains (1) summary
      cl00456
      Location:59664
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    2. XM_017024191.1XP_016879680.1  sodium/glucose cotransporter 5 isoform X1

    3. XM_011523652.1XP_011521954.1  sodium/glucose cotransporter 5 isoform X2

      Conserved Domains (1) summary
      cd11489
      Location:59675
      SLC5sbd_SGLT5; Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      18862768..18932795
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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