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    Gria1 glutamate receptor, ionotropic, AMPA1 (alpha 1) [ Mus musculus (house mouse) ]

    Gene ID: 14799, updated on 12-Mar-2017
    Official Symbol
    Gria1provided by MGI
    Official Full Name
    glutamate receptor, ionotropic, AMPA1 (alpha 1)provided by MGI
    Primary source
    MGI:MGI:95808
    See related
    Ensembl:ENSMUSG00000020524 Vega:OTTMUSG00000005703
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Glr1; Glr-1; GluA1; GluRA; Glur1; HIPA1; GluR-A; Glur-1; gluR-K1; 2900051M01Rik
    Orthologs
    Location:
    11 B1.3; 11 34.51 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (57011571..57330244)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (56825193..57143746)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 46261 Neighboring gene predicted gene, 39826 Neighboring gene ribosomal protein S6 pseudogene Neighboring gene family with sequence similarity 114, member A2 Neighboring gene microfibrillar-associated protein 3

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    AMPA glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    AMPA glutamate receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    G-protein alpha-subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    G-protein beta-subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    adenylate cyclase binding ISO
    Inferred from Sequence Orthology
    more info
     
    beta-2 adrenergic receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular-glutamate-gated ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    ionotropic glutamate receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    myosin V binding ISO
    Inferred from Sequence Orthology
    more info
     
    neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase A binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    chemical synaptic transmission IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chemical synaptic transmission, postsynaptic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    long term synaptic depression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    long-term memory ISO
    Inferred from Sequence Orthology
    more info
     
    modulation of synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal action potential ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    receptor internalization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of postsynaptic membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of receptor recycling ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    response to toxic substance ISO
    Inferred from Sequence Orthology
    more info
     
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    AMPA glutamate receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    AMPA glutamate receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    asymmetric synapse ISO
    Inferred from Sequence Orthology
    more info
     
    axonal spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dendritic shaft ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine membrane ISO
    Inferred from Sequence Orthology
    more info
     
    early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    excitatory synapse ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of postsynaptic density membrane IC
    Inferred by Curator
    more info
    PubMed 
    ionotropic glutamate receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuromuscular junction ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    neuron spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron spine ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    recycling endosome ISO
    Inferred from Sequence Orthology
    more info
     
    synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synapse ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    glutamate receptor 1
    Names
    AMPA-selective glutamate receptor 1
    glutamate receptor A
    glutamate receptor ionotropic, AMPA 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113325.2NP_001106796.1  glutamate receptor 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001106796.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate in-frame exon, compared to variant 2, resulting in a protein (isoform 1) with a distinct internal segment compared to isoform 2.
      Source sequence(s)
      AK049958, AL663055, BC056397
      Consensus CDS
      CCDS48800.1
      UniProtKB/Swiss-Prot
      P23818
      UniProtKB/TrEMBL
      Q7TNB5
      Related
      ENSMUSP00000044494, OTTMUSP00000005878, ENSMUST00000036315, OTTMUST00000012688
      Conserved Domains (4) summary
      cd06390
      Location:26389
      PBP1_iGluR_AMPA_GluR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor
      cd13729
      Location:406787
      PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:538817
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:37372
      ANF_receptor; Receptor family ligand binding region
    2. NM_001252403.1NP_001239332.1  glutamate receptor 1 isoform 3

      See identical proteins and their annotated locations for NP_001239332.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses a downstream, in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK135107, AL672177, BC056397
      Consensus CDS
      CCDS56770.1
      UniProtKB/TrEMBL
      F6YNQ1, Q7TNB5
      Related
      ENSMUSP00000117746, OTTMUSP00000054506, ENSMUST00000151045, OTTMUST00000097250
      Conserved Domains (4) summary
      cd13729
      Location:337718
      PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:469748
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:1303
      ANF_receptor; Receptor family ligand binding region
      cl10011
      Location:1320
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    3. NM_008165.4NP_032191.2  glutamate receptor 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_032191.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame exon, compared to variant 1, resulting in a protein (isoform 2) with a distinct internal segment compared to isoform 1.
      Source sequence(s)
      AL663055, BC056397
      Consensus CDS
      CCDS36159.1
      UniProtKB/TrEMBL
      Q7TNB5
      Related
      ENSMUSP00000091731, OTTMUSP00000005879, ENSMUST00000094179, OTTMUST00000012689
      Conserved Domains (4) summary
      cd06390
      Location:26389
      PBP1_iGluR_AMPA_GluR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor
      cd13729
      Location:406787
      PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:538817
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:37372
      ANF_receptor; Receptor family ligand binding region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      57011571..57330244
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314275.1XP_017169764.1  glutamate receptor 1 isoform X2

    2. XM_006532234.3XP_006532297.1  glutamate receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_006532297.1

      UniProtKB/TrEMBL
      F6YNQ1
      Conserved Domains (4) summary
      cd13729
      Location:337718
      PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:469748
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:1303
      ANF_receptor; Receptor family ligand binding region
      cl10011
      Location:1320
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

    RNA

    1. XR_388348.2 RNA Sequence

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