Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    CD24 CD24 molecule [ Homo sapiens (human) ]

    Gene ID: 100133941, updated on 25-Sep-2016
    Official Symbol
    CD24provided by HGNC
    Official Full Name
    CD24 moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:1645
    See related
    Ensembl:ENSG00000272398 MIM:600074; Vega:OTTHUMG00000188439
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD24A
    Summary
    This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and B cells and modulates growth and differentiation signals to these cells. The precursor protein is cleaved to a short 32 amino acid mature peptide which is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. This gene was missing from previous genome assemblies, but is properly located on chromosome 6. Non-transcribed pseudogenes have been designated on chromosomes 1, 15, 20, and Y. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
    Orthologs
    Location:
    6q21
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 6 NC_000006.12 (106969831..106976855, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 (PATCHES) NW_004504300.1 (274454..280365, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 12 Neighboring gene trafficking protein particle complex subunit 6A pseudogene Neighboring gene chromosome 6 open reading frame 203 Neighboring gene BEN domain containing 3

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
      Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hematopoietic cell lineage, conserved biosystem (from KEGG)
      Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • L1CAM interactions, organism-specific biosystem (from REACTOME)
      L1CAM interactions, organism-specific biosystemThe L1 family of cell adhesion molecules (L1CAMs) are a subfamily of the immunoglobulin superfamily of transmembrane receptors, comprised of four structurally related proteins: L1, Close Homolog of L...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Clone Names

    • FLJ22950, FLJ43543, MGC75043

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein tyrosine kinase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transducer activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    B cell receptor transport into membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    T cell costimulation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Wnt signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cell activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    chemokine receptor transport out of membrane raft ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cholesterol homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    glomerular parietal epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glomerular visceral epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    immune response-regulating cell surface receptor signaling pathway IC
    Inferred by Curator
    more info
    PubMed 
    intrinsic apoptotic signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of transforming growth factor beta3 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of activated T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of nephron tubule epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cytokine-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    regulation of epithelial cell differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    respiratory burst IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to estrogen IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to molecule of bacterial origin ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    single organismal cell-cell adhesion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    anchored component of external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    signal transducer CD24
    Names
    CD24 antigen (small cell lung carcinoma cluster 4 antigen)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_041768.1 RefSeqGene

      Range
      5001..12025
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001291737.1NP_001278666.1  signal transducer CD24 isoform a preproprotein

      See identical proteins and their annotated locations for NP_001278666.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode isoform a.
      Source sequence(s)
      AK026603, AK125531, AU125939, BU580553, DA753855
      Consensus CDS
      CCDS75499.1
      UniProtKB/Swiss-Prot
      P25063
      UniProtKB/TrEMBL
      B6EC88
      Related
      ENSP00000483838, OTTHUMP00000276599, ENST00000610952, OTTHUMT00000477247
      Conserved Domains (1) summary
      pfam14984
      Location:4779
      CD24; CD24 protein
    2. NM_001291738.1NP_001278667.1  signal transducer CD24 isoform a preproprotein

      See identical proteins and their annotated locations for NP_001278667.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode isoform a.
      Source sequence(s)
      AK026603, AK125531, BU580553, DA378105
      Consensus CDS
      CCDS75499.1
      UniProtKB/Swiss-Prot
      P25063
      UniProtKB/TrEMBL
      B6EC88
      Related
      ENSP00000475625, ENST00000606017
      Conserved Domains (1) summary
      pfam14984
      Location:4779
      CD24; CD24 protein
    3. NM_001291739.1NP_001278668.1  signal transducer CD24 isoform b

      See identical proteins and their annotated locations for NP_001278668.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is longer than isoform a.
      Source sequence(s)
      AK026603, AK125531, BU580553, DA518957
      Consensus CDS
      CCDS78166.1
      UniProtKB/TrEMBL
      A0A087WYI6
      Related
      ENSP00000481841, OTTHUMP00000276597, ENST00000622315, OTTHUMT00000477245
      Conserved Domains (1) summary
      pfam14984
      Location:96128
      CD24; CD24 protein
    4. NM_013230.3NP_037362.1  signal transducer CD24 isoform a preproprotein

      See identical proteins and their annotated locations for NP_037362.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode isoform a.
      Source sequence(s)
      AK026603, AK125531, BG755979, BU580553
      Consensus CDS
      CCDS75499.1
      UniProtKB/Swiss-Prot
      P25063
      UniProtKB/TrEMBL
      B6EC88
      Related
      ENSP00000483985, OTTHUMP00000276593, ENST00000619133, OTTHUMT00000477241
      Conserved Domains (1) summary
      pfam14984
      Location:4779
      CD24; CD24 protein

    RNA

    1. NR_117089.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks the internal exon and contains an alternate 5' terminal exon, compared to variant 1. This variant is represented as non-coding because it lacks an in-frame ORF, compared to variant 1.
      Source sequence(s)
      AK026603, AK125531, AU125939, BU580553, DA745135
    2. NR_117090.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks the internal exon, compared to variant 1. This variant is represented as non-coding because it lacks an in-frame ORF, compared to variant 1.
      Source sequence(s)
      AK026603, AK125531, BG755979, BU580553, DA253943

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p7 Primary Assembly

      Range
      106969831..106976855 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center