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    Isg15 ISG15 ubiquitin-like modifier [ Mus musculus (house mouse) ]

    Gene ID: 100038882, updated on 12-Mar-2017
    Official Symbol
    Isg15provided by MGI
    Official Full Name
    ISG15 ubiquitin-like modifierprovided by MGI
    Primary source
    MGI:MGI:1855694
    See related
    Ensembl:ENSMUSG00000035692
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G1p2; IP17; Irfp; UCRP; IGI15
    Orthologs
    Location:
    4 E2; 4
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (156199424..156200818, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (155573533..155574927, complement)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene ring finger 223 Neighboring gene agrin Neighboring gene predicted gene, 46878 Neighboring gene expressed sequence AW011738 Neighboring gene PPARGC1 and ESRR induced regulator, muscle 1 Neighboring gene predicted gene, 46877

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC18616, MGC103144, MGC130321

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein tag IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    ISG15-protein conjugation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ISG15-protein conjugation ISO
    Inferred from Sequence Orthology
    more info
     
    defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    modification-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of interferon-gamma production ISO
    Inferred from Sequence Orthology
    more info
     
    response to type I interferon ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    ubiquitin-like protein ISG15
    Names
    interferon, alpha-inducible protein
    interferon-induced 15 kDa protein
    interferon-induced 15-KDa protein
    interferon-induced 17 kDa protein
    interferon-stimulated protein (15 kDa)
    interferon-stimulated protein 15
    ubiquitin cross-reactive protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015783.3NP_056598.2  ubiquitin-like protein ISG15 precursor

      See identical proteins and their annotated locations for NP_056598.2

      Status: VALIDATED

      Source sequence(s)
      CT998563
      Consensus CDS
      CCDS51405.1
      UniProtKB/Swiss-Prot
      Q64339
      UniProtKB/TrEMBL
      Q4FJR9
      Related
      ENSMUSP00000082548, ENSMUST00000085425
      Conserved Domains (3) summary
      cd01792
      Location:178
      ISG15_repeat1; ISG15 ubiquitin-like protein, first repeat of 2
      cd01810
      Location:82155
      ISG15_repeat2; ISG15 ubiquitin-like protein, second repeat of 2
      smart00213
      Location:373
      UBQ; Ubiquitin homologues

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      156199424..156200818 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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