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    STARD13 StAR related lipid transfer domain containing 13 [ Homo sapiens (human) ]

    Gene ID: 90627, updated on 7-May-2017
    Official Symbol
    STARD13provided by HGNC
    Official Full Name
    StAR related lipid transfer domain containing 13provided by HGNC
    Primary source
    HGNC:HGNC:19164
    See related
    Ensembl:ENSG00000133121 MIM:609866; Vega:OTTHUMG00000016708
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DLC2; GT650; ARHGAP37; LINC00464
    Summary
    This gene encodes a protein which contains an N-terminal sterile alpha motif (SAM) for protein-protein interactions, followed by an ATP/GTP-binding motif, a GTPase-activating protein (GAP) domain, and a C-terminal STAR-related lipid transfer (START) domain. It may be involved in regulation of cytoskeletal reorganization, cell proliferation, and cell motility, and acts as a tumor suppressor in hepatoma cells. The gene is located in a region of chromosome 13 that is associated with loss of heterozygosity in hepatocellular carcinomas. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
    Orthologs
    Location:
    13q13.1-q13.2
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 13 NC_000013.11 (33103135..33676835, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (33677272..34250932, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene TOMM22 pseudogene 3 Neighboring gene klotho Neighboring gene STARD13 antisense RNA Neighboring gene long intergenic non-protein coding RNA 2344 Neighboring gene uncharacterized LOC102723406 Neighboring gene uncharacterized LOC107984551 Neighboring gene RNA, U5A small nuclear 4, pseudogene Neighboring gene replication factor C subunit 3

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A genome-wide association meta-analysis of plasma Aβ peptides concentrations in the elderly.
    NHGRI GWA Catalog
    A genome-wide association study of behavioral disinhibition.
    NHGRI GWA Catalog
    Genome-wide association study of body mass index in 23 000 individuals with and without asthma.
    NHGRI GWA Catalog
    Genome-wide association study of intracranial aneurysm identifies three new risk loci.
    NHGRI GWA Catalog
    • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
      Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ37385

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTPase activator activity TAS
    Traceable Author Statement
    more info
     
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    endothelial cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endothelial tube lumen extension IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    endothelial tube lumen extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell migration involved in sprouting angiogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of cell migration involved in sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     
    lipid particle IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    stAR-related lipid transfer protein 13
    Names
    Rho GTPase activating protein on chromosome 13q12
    StAR-related lipid transfer (START) domain containing 13
    deleted in liver cancer 2 protein
    long intergenic non-protein coding RNA 464

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029752.2 RefSeqGene

      Range
      396072..578701
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001243466.1NP_001230395.1  stAR-related lipid transfer protein 13 isoform 5

      See identical proteins and their annotated locations for NP_001230395.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains an alternate 5' terminal exon, and differs at the 3' end compared to variant 1. This results in a shorter isoform (5) with distinct N- and C- termini compared to isoform 1.
      Source sequence(s)
      AK308453, BC046563
      UniProtKB/Swiss-Prot
      Q9Y3M8
      Conserved Domains (3) summary
      cd09592
      Location:49112
      SAM_DLC2; SAM domain of STARD13-like subfamily
      smart00454
      Location:53112
      SAM; Sterile alpha motif
      cl02570
      Location:649686
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    2. NM_001243474.1NP_001230403.1  stAR-related lipid transfer protein 13 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) contains an alternate 5' terminal exon, and differs at the 3' end compared to variant 1. This results in translation initiation from an in-frame downstream AUG, and an isoform (6) with a shorter N-terminus, and a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK091804, AK308453, BC046563, BP233049
      UniProtKB/Swiss-Prot
      Q9Y3M8
      UniProtKB/TrEMBL
      B3KRK6
      Conserved Domains (1) summary
      cl02570
      Location:539642
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    3. NM_001243476.2NP_001230405.1  stAR-related lipid transfer protein 13 isoform 4

      See identical proteins and their annotated locations for NP_001230405.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks a portion of the 5' coding region and contains multiple alternate 5' exons, and initiates initiates translation at an alternate start codon, compared to variant 1. This results in a shorter isoform (4) with a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AA256386, AK308453, AY082589, BX647695, CB163673, DA312208, DB449764
      UniProtKB/Swiss-Prot
      Q9Y3M8
      Conserved Domains (4) summary
      cd08909
      Location:8651069
      START_STARD13-like; C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
      cd09592
      Location:2285
      SAM_DLC2; SAM domain of STARD13-like subfamily
      smart00454
      Location:2685
      SAM; Sterile alpha motif
      cd04375
      Location:622839
      RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
    4. NM_052851.2NP_443083.1  stAR-related lipid transfer protein 13 isoform 3

      See identical proteins and their annotated locations for NP_443083.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' terminal exon compared to variant 1. This results in translation initiation from an in-frame downstream AUG, and an isoform (3, also known as DLC2gamma) with a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AA256386, AL049801, AY082590, AY082591, AY366448, BP233049, CB163673
      Consensus CDS
      CCDS9350.1
      UniProtKB/Swiss-Prot
      Q9Y3M8
      UniProtKB/TrEMBL
      B2R789
      Related
      ENSP00000382300.3, OTTHUMP00000205446, ENST00000399365.7, OTTHUMT00000044437
      Conserved Domains (2) summary
      cd08909
      Location:782986
      START_STARD13-like; C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
      cd04375
      Location:539756
      RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
    5. NM_178006.3NP_821074.1  stAR-related lipid transfer protein 13 isoform 1

      See identical proteins and their annotated locations for NP_821074.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1, also known as DLC2alpha).
      Source sequence(s)
      AA256386, AY082589, AY082590, AY366448, CB163673, DC402824
      Consensus CDS
      CCDS9348.1
      UniProtKB/Swiss-Prot
      Q9Y3M8
      UniProtKB/TrEMBL
      A0A024RDV4
      Related
      ENSP00000338785.4, OTTHUMP00000178559, ENST00000336934.9, OTTHUMT00000276118
      Conserved Domains (4) summary
      cd08909
      Location:9001104
      START_STARD13-like; C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
      cd09592
      Location:57120
      SAM_DLC2; SAM domain of STARD13-like subfamily
      smart00454
      Location:61120
      SAM; Sterile alpha motif
      cd04375
      Location:657874
      RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
    6. NM_178007.2NP_821075.1  stAR-related lipid transfer protein 13 isoform 2

      See identical proteins and their annotated locations for NP_821075.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon compared to variant 1. This results in a shorter isoform (2, also known as DLC2beta) with a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AA256386, AY082590, AY366448, CB163673
      Consensus CDS
      CCDS9349.1
      UniProtKB/Swiss-Prot
      Q9Y3M8
      Related
      ENSP00000255486.4, OTTHUMP00000178560, ENST00000255486.8, OTTHUMT00000044439
      Conserved Domains (4) summary
      cd08909
      Location:8921096
      START_STARD13-like; C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
      cd09592
      Location:49112
      SAM_DLC2; SAM domain of STARD13-like subfamily
      smart00454
      Location:53112
      SAM; Sterile alpha motif
      cd04375
      Location:649866
      RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p7 Primary Assembly

      Range
      33103135..33676835 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017020835.1XP_016876324.1  stAR-related lipid transfer protein 13 isoform X2

      Conserved Domains (4) summary
      cd08909
      Location:8651069
      START_STARD13-like; C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
      cd09592
      Location:2285
      SAM_DLC2; SAM domain of STARD13-like subfamily
      smart00454
      Location:2685
      SAM; Sterile alpha motif
      cd04375
      Location:622839
      RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
    2. XM_011535299.2XP_011533601.1  stAR-related lipid transfer protein 13 isoform X2

      See identical proteins and their annotated locations for XP_011533601.1

      Conserved Domains (4) summary
      cd08909
      Location:8651069
      START_STARD13-like; C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
      cd09592
      Location:2285
      SAM_DLC2; SAM domain of STARD13-like subfamily
      smart00454
      Location:2685
      SAM; Sterile alpha motif
      cd04375
      Location:622839
      RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
    3. XM_017020834.1XP_016876323.1  stAR-related lipid transfer protein 13 isoform X1

    Alternate CHM1_1.1

    Genomic

    1. NC_018924.2 Alternate CHM1_1.1

      Range
      33644794..34218922 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_178008.1: Suppressed sequence

      Description
      NM_178008.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Support Center