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    ADAM7 ADAM metallopeptidase domain 7 [ Homo sapiens (human) ]

    Gene ID: 8756, updated on 29-Mar-2018
    Official Symbol
    ADAM7provided by HGNC
    Official Full Name
    ADAM metallopeptidase domain 7provided by HGNC
    Primary source
    HGNC:HGNC:214
    See related
    Ensembl:ENSG00000069206 MIM:607310; Vega:OTTHUMG00000097859
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EAPI; GP83; GP-83; ADAM 7; ADAM-7
    Summary
    This gene encodes a member of the ADAMs family of zinc proteases. These transmembrane proteins play roles in multiple processes including cell signaling, adhesion and migration. The encoded protein lacks protease activity and may play roles in protein-protein interactions and cell adhesion processes including sperm-egg fusion. Mutations in this gene may be involved in the progression of melanoma. [provided by RefSeq, Oct 2011]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    See ADAM7 in Genome Data Viewer
    Location:
    8p21.2
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (24440996..24509565)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (24298509..24370273)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929294 Neighboring gene ADAM metallopeptidase domain 28 Neighboring gene ADAM like decysin 1 Neighboring gene uncharacterized LOC101929315 Neighboring gene uncharacterized LOC107986932 Neighboring gene uncharacterized LOC107986882

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    NHGRI GWAS Catalog

    Description
    White matter integrity as an intermediate phenotype: exploratory genome-wide association analysis in individuals at high risk of bipolar disorder.
    NHGRI GWA Catalog

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 7
    Names
    a disintegrin and metalloproteinase domain 7
    epididymal apical protein I
    sperm maturation-related glycoprotein GP-83

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003817.3NP_003808.2  disintegrin and metalloproteinase domain-containing protein 7 preproprotein

      See identical proteins and their annotated locations for NP_003808.2

      Status: REVIEWED

      Source sequence(s)
      AC024958, AK292492
      Consensus CDS
      CCDS6045.1
      UniProtKB/Swiss-Prot
      Q9H2U9
      Related
      ENSP00000175238.5, OTTHUMP00000123543, ENST00000175238.10, OTTHUMT00000215150
      Conserved Domains (5) summary
      smart00050
      Location:411485
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:488624
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:199392
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:199394
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:39153
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

      Range
      24440996..24509565
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017013943.1XP_016869432.1  disintegrin and metalloproteinase domain-containing protein 7 isoform X1

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