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    CCKBR cholecystokinin B receptor [ Homo sapiens (human) ]

    Gene ID: 887, updated on 8-Oct-2017
    Official Symbol
    CCKBRprovided by HGNC
    Official Full Name
    cholecystokinin B receptorprovided by HGNC
    Primary source
    HGNC:HGNC:1571
    See related
    Ensembl:ENSG00000110148 MIM:118445; Vega:OTTHUMG00000133380
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GASR; CCK-B; CCK2R
    Summary
    This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. Alternative splicing results in multiple transcript variants. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. [provided by RefSeq, Dec 2015]
    Orthologs
    Location:
    11p15.4
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 11 NC_000011.10 (6259611..6272127)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (6280841..6293363)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene chromosome 11 open reading frame 42 Neighboring gene family with sequence similarity 160 member A2 Neighboring gene cyclic nucleotide gated channel alpha 4 Neighboring gene uncharacterized LOC101927825 Neighboring gene caveolae associated protein 3 Neighboring gene sphingomyelin phosphodiesterase 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Calcium signaling pathway, organism-specific biosystem (from KEGG)
      Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Calcium signaling pathway, conserved biosystem (from KEGG)
      Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Cell-type Dependent Selectivity of CCK2R Signaling, organism-specific biosystem (from WikiPathways)
      Cell-type Dependent Selectivity of CCK2R Signaling, organism-specific biosystemThis pathway is based on Figure 7 of "Cell-Type Specific CCK2 Receptor Signaling Underlies the Cholecystokinin-Mediated Selective Excitation of Hippocampal Parvalbumin-Positive Fast-Spiking Basket Ce...
    • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
      Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
    • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
      GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
    • GPCRs, Other, organism-specific biosystem (from WikiPathways)
      GPCRs, Other, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
    • Gastric acid secretion, organism-specific biosystem (from KEGG)
      Gastric acid secretion, organism-specific biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
    • Gastric acid secretion, conserved biosystem (from KEGG)
      Gastric acid secretion, conserved biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
    • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
      Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
    • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, organism-specific biosystem
      Neuroactive ligand-receptor interaction
    • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, conserved biosystem
      Neuroactive ligand-receptor interaction
    • Peptide GPCRs, organism-specific biosystem (from WikiPathways)
      Peptide GPCRs, organism-specific biosystem
      Peptide GPCRs
    • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
      Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
    • Secretion of Hydrochloric Acid in Parietal Cells, organism-specific biosystem (from WikiPathways)
      Secretion of Hydrochloric Acid in Parietal Cells, organism-specific biosystemGastric parietal cells are stomach epithelial cells. They secrete gastric acid and intrinsic factor. This pathway is primarily based on https://en.wikipedia.org/wiki/Parietal_cell
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    1-phosphatidylinositol-3-kinase regulator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    cholecystokinin receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    gastrin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylinositol phospholipase C activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    type B gastrin/cholecystokinin receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    cell surface receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cholecystokinin signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    digestion TAS
    Traceable Author Statement
    more info
    PubMed 
    digestive tract development IEA
    Inferred from Electronic Annotation
    more info
     
    feeding behavior TAS
    Traceable Author Statement
    more info
    PubMed 
    gastric acid secretion IEA
    Inferred from Electronic Annotation
    more info
     
    gland development IEA
    Inferred from Electronic Annotation
    more info
     
    phospholipase C-activating G-protein coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of phosphatidylinositol 3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    sensory perception TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of plasma membrane IC
    Inferred by Curator
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    gastrin/cholecystokinin type B receptor
    Names
    CCK-B receptor
    CCK-BR
    CCK2 receptor
    CCK2-R
    cholecystokinin-2 receptor
    gastrin receptor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030591.1 RefSeqGene

      Range
      5001..17454
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001318029.1NP_001304958.1  gastrin/cholecystokinin type B receptor isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC068733, AK226020, CD013884, CX762706, D13305, DA297178
      Consensus CDS
      CCDS81550.1
      UniProtKB/Swiss-Prot
      P32239
      UniProtKB/TrEMBL
      E9PIC8
      Related
      ENSP00000432079.1, OTTHUMP00000229568, ENST00000532715.5, OTTHUMT00000383766
      Conserved Domains (2) summary
      pfam00001
      Location:52306
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:60159
      7tm_4; Olfactory receptor
    2. NM_176875.3NP_795344.1  gastrin/cholecystokinin type B receptor isoform 1

      See identical proteins and their annotated locations for NP_795344.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC068733, AK226020, CX762706, D13305, DA297178
      Consensus CDS
      CCDS7761.1
      UniProtKB/Swiss-Prot
      P32239
      Related
      ENSP00000335544.2, OTTHUMP00000164537, ENST00000334619.6, OTTHUMT00000257230
      Conserved Domains (2) summary
      cd14964
      Location:5781
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:55401
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p7 Primary Assembly

      Range
      6259611..6272127
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005253210.1XP_005253267.1  gastrin/cholecystokinin type B receptor isoform X1

      UniProtKB/Swiss-Prot
      P32239
      Related
      ENSP00000435534.1, OTTHUMP00000229571, ENST00000525462.1, OTTHUMT00000383770
      Conserved Domains (2) summary
      pfam00001
      Location:71459
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:60243
      7tm_4; Olfactory receptor
    2. XM_017018516.1XP_016874005.1  gastrin/cholecystokinin type B receptor isoform X2

      UniProtKB/Swiss-Prot
      P32239
      Conserved Domains (2) summary
      pfam00001
      Location:5324
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:5177
      7tm_4; Olfactory receptor

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      6280135..6292585
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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