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    Kcnma1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 [ Mus musculus (house mouse) ]

    Gene ID: 16531, updated on 8-Oct-2017
    Official Symbol
    Kcnma1provided by MGI
    Official Full Name
    potassium large conductance calcium-activated channel, subfamily M, alpha member 1provided by MGI
    Primary source
    MGI:MGI:99923
    See related
    Ensembl:ENSMUSG00000063142 Vega:OTTMUSG00000045153
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Slo; BKCa; Slo1; mSlo; MaxiK; mSlo1; 5730414M22Rik
    Orthologs
    Location:
    14; 14 A3
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (23292291..24004952, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (24117983..24823427, complement)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene leucine rich melanocyte differentiation associated Neighboring gene predicted gene, 30783 Neighboring gene predicted gene 10248 Neighboring gene 40S ribosomal protein S25 pseudogene Neighboring gene uncharacterized LOC105245696 Neighboring gene RIKEN cDNA 4930519K11 gene Neighboring gene predicted gene, 46444

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Ca2+ activated K+ channels, organism-specific biosystem (from REACTOME)
      Ca2+ activated K+ channels, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Insulin secretion, organism-specific biosystem (from KEGG)
      Insulin secretion, organism-specific biosystemPancreatic beta cells are specialised endocrine cells that continuously sense the levels of blood sugar and other fuels and, in response, secrete insulin to maintain normal fuel homeostasis. Glucose-...
    • Neuronal System, organism-specific biosystem (from REACTOME)
      Neuronal System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Pancreatic secretion, organism-specific biosystem (from KEGG)
      Pancreatic secretion, organism-specific biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
    • Pancreatic secretion, conserved biosystem (from KEGG)
      Pancreatic secretion, conserved biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
    • PodNet: protein-protein interactions in the podocyte, organism-specific biosystem (from WikiPathways)
      PodNet: protein-protein interactions in the podocyte, organism-specific biosystemPodNet is a manually curated network of protein-protein interactions occurring in the podocyte.
    • Potassium Channels, organism-specific biosystem (from REACTOME)
      Potassium Channels, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Renin secretion, organism-specific biosystem (from KEGG)
      Renin secretion, organism-specific biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
    • Renin secretion, conserved biosystem (from KEGG)
      Renin secretion, conserved biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
    • Salivary secretion, organism-specific biosystem (from KEGG)
      Salivary secretion, organism-specific biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
    • Salivary secretion, conserved biosystem (from KEGG)
      Salivary secretion, conserved biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
    • Splicing factor NOVA regulated synaptic proteins, organism-specific biosystem (from WikiPathways)
      Splicing factor NOVA regulated synaptic proteins, organism-specific biosystemSynaptic Communication influenced by NOVA-splicing regulation
    • Vascular smooth muscle contraction, organism-specific biosystem (from KEGG)
      Vascular smooth muscle contraction, organism-specific biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
    • Vascular smooth muscle contraction, conserved biosystem (from KEGG)
      Vascular smooth muscle contraction, conserved biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
    • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
      XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.
    • cGMP-PKG signaling pathway, organism-specific biosystem (from KEGG)
      cGMP-PKG signaling pathway, organism-specific biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
    • cGMP-PKG signaling pathway, conserved biosystem (from KEGG)
      cGMP-PKG signaling pathway, conserved biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium-activated potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium-activated potassium channel activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    calcium-activated potassium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    calcium-activated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    large conductance calcium-activated potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    large conductance calcium-activated potassium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    large conductance calcium-activated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    potassium channel activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    potassium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    voltage-gated ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    voltage-gated potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    voltage-gated potassium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    voltage-gated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    adult walking behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    auditory receptor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular potassium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    eye blink reflex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    locomotor rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    micturition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    micturition ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell volume IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell volume ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of small intestine smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    neuromuscular process controlling balance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuronal action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of blood vessel diameter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    potassium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    protein homooligomerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of aldosterone metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of blood vessel diameter ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of membrane potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    relaxation of vascular smooth muscle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    response to carbon monoxide ISO
    Inferred from Sequence Orthology
    more info
     
    response to corticosteroid ISO
    Inferred from Sequence Orthology
    more info
     
    response to estrogen ISO
    Inferred from Sequence Orthology
    more info
     
    response to hypoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    response to osmotic stress ISO
    Inferred from Sequence Orthology
    more info
     
    response to pH ISO
    Inferred from Sequence Orthology
    more info
     
    saliva secretion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    smooth muscle contraction involved in micturition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    smooth muscle contraction involved in micturition ISO
    Inferred from Sequence Orthology
    more info
     
    transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    vasodilation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    caveola ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IC
    Inferred by Curator
    more info
    PubMed 
    integral component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    presynaptic active zone membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    terminal bouton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    voltage-gated potassium channel complex IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    calcium-activated potassium channel subunit alpha-1
    Names
    BK channel alpha subunit
    BKCA alpha
    KCa1.1
    calcium-activated potassium channel, subfamily M subunit alpha-1
    k(VCA)alpha
    maxi K channel
    slo homolog
    slo-alpha
    slowpoke homolog

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253358.1NP_001240287.1  calcium-activated potassium channel subunit alpha-1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC154420, AC154433, AC154795, CT010582, CT025624
      Conserved Domains (3) summary
      pfam00520
      Location:179396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    2. NM_001253359.1NP_001240288.1  calcium-activated potassium channel subunit alpha-1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the 3' coding region, which does not affect the reading frame, compared to variant 1. The resulting isoform (2) lacks an internal single aa, compared to isoform 1.
      Source sequence(s)
      AC154420, AC154433, AC154795, CT010582, CT025624
      Conserved Domains (3) summary
      pfam00520
      Location:179396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    3. NM_001253360.1NP_001240289.1  calcium-activated potassium channel subunit alpha-1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon and has an alternate splice site in the 3' coding region, which does not affect the reading frame, compared to variant 1. The resulting isoform (3) lacks an internal segment and an internal single aa, compared to isoform 1.
      Source sequence(s)
      AC154420, AC154433, AC154795, CT010582, CT025624
      Related
      ENSMUSP00000141069.2, ENSMUST00000188210.7
      Conserved Domains (3) summary
      pfam00520
      Location:179396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    4. NM_001253361.1NP_001240290.1  calcium-activated potassium channel subunit alpha-1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences in the coding region, one of which results in a frameshift, compared to variant 1. The resulting isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC154420, AC154433, AC154795, CT010582, CT025624
      Related
      ENSMUSP00000153214.1, ENSMUST00000224077.1
      Conserved Domains (4) summary
      pfam00520
      Location:210396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306391
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    5. NM_001253362.1NP_001240291.1  calcium-activated potassium channel subunit alpha-1 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has multiple differences in the coding region, one of which results in a frameshift, compared to variant 1. The resulting isoform (5) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC154420, AC154433, AC154795, CT010582, CT025624
      Related
      ENSMUSP00000153362.1, ENSMUST00000223655.1
      Conserved Domains (4) summary
      pfam00520
      Location:210396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306391
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    6. NM_001253363.1NP_001240292.1  calcium-activated potassium channel subunit alpha-1 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) has multiple differences in the coding region, one of which results in a frameshift, compared to variant 1. The resulting isoform (6) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK135652, BC065068
      Consensus CDS
      CCDS79278.1
      UniProtKB/TrEMBL
      A0A087WQN5, Q3UXG3
      Related
      ENSMUSP00000140275.1, OTTMUSP00000066221, ENSMUST00000188285.6, OTTMUST00000118654
      Conserved Domains (4) summary
      pfam00520
      Location:210396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306391
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    7. NM_001253364.1NP_001240293.1  calcium-activated potassium channel subunit alpha-1 isoform 7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (7) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC154420, AC154433, AC154795, CT010582, CT025624
      Related
      ENSMUSP00000153291.1, ENSMUST00000224232.1
      Conserved Domains (4) summary
      pfam00520
      Location:210396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306391
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    8. NM_001253365.1NP_001240294.1  calcium-activated potassium channel subunit alpha-1 isoform 9

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (9) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AK135652, BC065068, L16912
      UniProtKB/Swiss-Prot
      Q08460
      UniProtKB/TrEMBL
      Q3UXG3
      Related
      ENSMUSP00000153078.1, ENSMUST00000224025.1
      Conserved Domains (3) summary
      pfam00520
      Location:179396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    9. NM_001253366.1NP_001240295.1  calcium-activated potassium channel subunit alpha-1 isoform 10

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) lacks an in-frame exon and has an alternate splice site in the 3' coding region, which does not affect the reading frame, compared to variant 1. The resulting isoform (10) lacks an internal segment and an internal single aa, compared to isoform 1.
      Source sequence(s)
      AC154420, AC154433, AC154795, CT010582, CT025624
      Conserved Domains (3) summary
      pfam00520
      Location:179396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    10. NM_001253367.1NP_001240296.1  calcium-activated potassium channel subunit alpha-1 isoform 11

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) lacks an in-frame exon and has an alternate splice site in the 3' coding region, which does not affect the reading frame, compared to variant 1. The resulting isoform (11) lacks an internal segment and an internal single aa, compared to isoform 1.
      Source sequence(s)
      AC154420, AC154433, AC154795, CT010582, CT025624
      Related
      ENSMUSP00000153670.1, ENSMUST00000225431.1
      Conserved Domains (3) summary
      pfam00520
      Location:179396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    11. NM_001253368.1NP_001240297.1  calcium-activated potassium channel subunit alpha-1 isoform 12

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (12) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC154420, AC154433, AC154795, CT010582, CT025624
      Related
      ENSMUSP00000153527.1, ENSMUST00000224812.1
      Conserved Domains (4) summary
      pfam00520
      Location:210396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306391
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    12. NM_001253369.1NP_001240298.1  calcium-activated potassium channel subunit alpha-1 isoform 13

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13) has multiple differences in the coding region, one of which results in a frameshift, compared to variant 1. The resulting isoform (13) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK135652, BC065068, U09383
      Consensus CDS
      CCDS79277.1
      UniProtKB/Swiss-Prot
      Q08460
      UniProtKB/TrEMBL
      A0A087WSJ2, Q3UXG3
      Related
      ENSMUSP00000153247.1, OTTMUSP00000066222, ENSMUST00000145596.2, OTTMUST00000118655
      Conserved Domains (3) summary
      pfam00520
      Location:179396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    13. NM_001253370.1NP_001240299.1  calcium-activated potassium channel subunit alpha-1 isoform 14

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (14) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC154420, AC154433, AC154795, CT010582, CT025624
      Related
      ENSMUSP00000153083.1, ENSMUST00000225471.1
      Conserved Domains (4) summary
      pfam00520
      Location:210396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306391
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    14. NM_001253371.1NP_001240300.1  calcium-activated potassium channel subunit alpha-1 isoform 15

      Status: VALIDATED

      Description
      Transcript Variant: This variant (15) lacks an exon and has an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The resulting isoform (15) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC154420, AC154433, AC154795, CT010582, CT025624
      Conserved Domains (3) summary
      pfam00520
      Location:179396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    15. NM_001253372.1NP_001240301.1  calcium-activated potassium channel subunit alpha-1 isoform 16

      Status: VALIDATED

      Description
      Transcript Variant: This variant (16) has multiple differences in the coding region, one of which results in a frameshift, compared to variant 1. The resulting isoform (16) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC154420, AC154433, AC154795, CT010582, CT025624
      Related
      ENSMUSP00000153584.1, ENSMUST00000225315.1
      Conserved Domains (4) summary
      pfam00520
      Location:210396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306391
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    16. NM_001253373.1NP_001240302.1  calcium-activated potassium channel subunit alpha-1 isoform 17

      Status: VALIDATED

      Description
      Transcript Variant: This variant (17) has multiple differences in the coding region, one of which results in a frameshift, compared to variant 1. The resulting isoform (17) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC154420, AC154433, AC154795, CT010582, CT025624
      Related
      ENSMUSP00000152959.1, ENSMUST00000225556.1
      Conserved Domains (4) summary
      pfam00520
      Location:210396
      Ion_trans; Ion transport protein
      pfam03493
      Location:532581
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306391
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    17. NM_001253374.1NP_001240303.1  calcium-activated potassium channel subunit alpha-1 isoform 18

      Status: VALIDATED

      Description
      Transcript Variant: This variant (18) lacks two in-frame exons in the coding region, compared to variant 1. The resulting isoform (18) lacks two internal segments, compared to isoform 1.
      Source sequence(s)
      AC154420, AC154433, AC154795, CT010582, CT025624
      Related
      ENSMUSP00000152999.1, ENSMUST00000224787.1
      Conserved Domains (3) summary
      pfam00520
      Location:128342
      Ion_trans; Ion transport protein
      pfam03493
      Location:491579
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      cl21454
      Location:356469
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    18. NM_001253375.1NP_001240304.1  calcium-activated potassium channel subunit alpha-1 isoform 19

      Status: VALIDATED

      Description
      Transcript Variant: This variant (19) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (19) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC154420, AC154433, AC154795, CT010582, CT025624
      Related
      ENSMUSP00000153316.1, ENSMUST00000224285.1
      Conserved Domains (3) summary
      pfam00520
      Location:179387
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    19. NM_001253376.1NP_001240305.1  calcium-activated potassium channel subunit alpha-1 isoform 20

      Status: VALIDATED

      Description
      Transcript Variant: This variant (20) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (20) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC154420, AC154433, AC154795, CT010582, CT025624
      Related
      ENSMUSP00000153216.1, ENSMUST00000223749.1
      Conserved Domains (3) summary
      pfam00520
      Location:179396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    20. NM_001253377.1NP_001240306.1  calcium-activated potassium channel subunit alpha-1 isoform 21

      Status: VALIDATED

      Description
      Transcript Variant: This variant (21) lacks three coding exons, one of which results in a frameshift, compared to variant 1. The resulting isoform (21) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC154420, AC154433, AC154795, CT010582, CT025624
      Consensus CDS
      CCDS79275.1
      UniProtKB/TrEMBL
      A0A087WQ41
      Related
      ENSMUSP00000140033.1, OTTMUSP00000066231, ENSMUST00000190044.6, OTTMUST00000118672
      Conserved Domains (3) summary
      pfam00520
      Location:179396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    21. NM_001253378.1NP_001240307.1  calcium-activated potassium channel subunit alpha-1 isoform 22

      Status: VALIDATED

      Description
      Transcript Variant: This variant (22) lacks three coding exons and has an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The resulting isoform (22) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC154420, AC154433, AC154795, CT010582, CT025624
      Related
      ENSMUSP00000153158.1, ENSMUST00000223727.1
      Conserved Domains (3) summary
      pfam00520
      Location:179396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    22. NM_010610.3NP_034740.2  calcium-activated potassium channel subunit alpha-1 isoform 8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) has multiple differences in the coding region, one of which results in a frameshift, compared to variant 1. The resulting isoform (8) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AF156674, AK135652, BC065068
      Consensus CDS
      CCDS79276.1
      UniProtKB/Swiss-Prot
      Q08460
      UniProtKB/TrEMBL
      A0A087WRS4, Q3UXG3
      Related
      ENSMUSP00000140751.1, OTTMUSP00000066232, ENSMUST00000188991.6, OTTMUST00000118673
      Conserved Domains (4) summary
      pfam00520
      Location:210396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306391
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      23292291..24004952 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518594.3XP_006518657.1  calcium-activated potassium channel subunit alpha-1 isoform X4

      Conserved Domains (4) summary
      pfam00520
      Location:210396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306391
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    2. XM_006518593.3XP_006518656.1  calcium-activated potassium channel subunit alpha-1 isoform X3

      Conserved Domains (4) summary
      pfam00520
      Location:210396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306391
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    3. XM_006518592.3XP_006518655.1  calcium-activated potassium channel subunit alpha-1 isoform X2

      Conserved Domains (4) summary
      pfam00520
      Location:210396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306391
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    4. XM_006518591.3XP_006518654.1  calcium-activated potassium channel subunit alpha-1 isoform X1

      Conserved Domains (4) summary
      pfam00520
      Location:210396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306391
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    5. XM_006518599.3XP_006518662.1  calcium-activated potassium channel subunit alpha-1 isoform X7

      Conserved Domains (4) summary
      pfam00520
      Location:210396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306391
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    6. XM_006518603.3XP_006518666.1  calcium-activated potassium channel subunit alpha-1 isoform X10

      Conserved Domains (4) summary
      pfam00520
      Location:210396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306391
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    7. XM_006518602.3XP_006518665.1  calcium-activated potassium channel subunit alpha-1 isoform X9

      Conserved Domains (4) summary
      pfam00520
      Location:210396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306391
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    8. XM_017315873.1XP_017171362.1  calcium-activated potassium channel subunit alpha-1 isoform X13

    9. XM_017315872.1XP_017171361.1  calcium-activated potassium channel subunit alpha-1 isoform X12

    10. XM_011244967.2XP_011243269.1  calcium-activated potassium channel subunit alpha-1 isoform X11

      Conserved Domains (4) summary
      pfam00520
      Location:210396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306391
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    11. XM_017315887.1XP_017171376.1  calcium-activated potassium channel subunit alpha-1 isoform X32

    12. XM_017315886.1XP_017171375.1  calcium-activated potassium channel subunit alpha-1 isoform X31

    13. XM_017315885.1XP_017171374.1  calcium-activated potassium channel subunit alpha-1 isoform X30

    14. XM_017315884.1XP_017171373.1  calcium-activated potassium channel subunit alpha-1 isoform X29

    15. XM_017315881.1XP_017171370.1  calcium-activated potassium channel subunit alpha-1 isoform X24

    16. XM_017315871.1XP_017171360.1  calcium-activated potassium channel subunit alpha-1 isoform X8

    17. XM_017315879.1XP_017171368.1  calcium-activated potassium channel subunit alpha-1 isoform X22

    18. XM_017315878.1XP_017171367.1  calcium-activated potassium channel subunit alpha-1 isoform X21

    19. XM_017315877.1XP_017171366.1  calcium-activated potassium channel subunit alpha-1 isoform X20

    20. XM_017315876.1XP_017171365.1  calcium-activated potassium channel subunit alpha-1 isoform X19

    21. XM_017315870.1XP_017171359.1  calcium-activated potassium channel subunit alpha-1 isoform X6

    22. XM_006518595.3XP_006518658.1  calcium-activated potassium channel subunit alpha-1 isoform X5

      Conserved Domains (4) summary
      pfam00520
      Location:210396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306391
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    23. XM_017315875.1XP_017171364.1  calcium-activated potassium channel subunit alpha-1 isoform X18

    24. XM_006518609.3XP_006518672.1  calcium-activated potassium channel subunit alpha-1 isoform X17

      Conserved Domains (4) summary
      pfam00520
      Location:210396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306391
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    25. XM_017315874.1XP_017171363.1  calcium-activated potassium channel subunit alpha-1 isoform X16

    26. XM_006518606.3XP_006518669.1  calcium-activated potassium channel subunit alpha-1 isoform X15

      Conserved Domains (4) summary
      pfam00520
      Location:210396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306391
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    27. XM_006518605.3XP_006518668.1  calcium-activated potassium channel subunit alpha-1 isoform X14

      Related
      ENSMUSP00000153312.1, ENSMUST00000224468.1
      Conserved Domains (4) summary
      pfam00520
      Location:210396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306391
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    28. XM_017315880.1XP_017171369.1  calcium-activated potassium channel subunit alpha-1 isoform X23

    29. XM_017315883.1XP_017171372.1  calcium-activated potassium channel subunit alpha-1 isoform X27

    30. XM_006518610.3XP_006518673.1  calcium-activated potassium channel subunit alpha-1 isoform X26

      Conserved Domains (4) summary
      pfam00520
      Location:210396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306391
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    31. XM_017315882.1XP_017171371.1  calcium-activated potassium channel subunit alpha-1 isoform X25

    32. XM_006518613.3XP_006518676.1  calcium-activated potassium channel subunit alpha-1 isoform X28

      Related
      ENSMUSP00000140154.2, OTTMUSP00000066230, ENSMUST00000190985.7, OTTMUST00000118671
      Conserved Domains (4) summary
      pfam00520
      Location:210396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306391
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
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