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    G6pc glucose-6-phosphatase, catalytic subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25634, updated on 26-Sep-2017
    Official Symbol
    G6pcprovided by RGD
    Official Full Name
    glucose-6-phosphatase, catalytic subunitprovided by RGD
    Primary source
    RGD:2644
    See related
    Ensembl:ENSRNOG00000051171 Vega:OTTRNOG00000000813
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    G6Pase
    Summary
    catalyzes the conversion of D-glucose 6-phosphate and H2O to D-glucose and phosphate in gluconeogenesis [RGD, Feb 2006]
    Annotation information
    Annotation category: suggests misassembly
    Expression
    Biased expression in Kidney (RPKM 1591.1) and Liver (RPKM 1555.8) See more
    Orthologs
    Location:
    10q31
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (89286009..89296213)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (89084064..89094265)

    Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene amine oxidase, copper containing 2, pseudogene 1 Neighboring gene amine oxidase, copper containing 3 Neighboring gene alanyl-tRNA synthetase domain containing 1 Neighboring gene prostaglandin E synthase 3 like

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC93613

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    glucose-6-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glucose-6-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    glucose-6-phosphatase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    phosphate ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphate ion binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    phosphotransferase activity, alcohol group as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    phosphotransferase activity, alcohol group as acceptor ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    cholesterol homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    gluconeogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    gluconeogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    glucose 6-phosphate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glucose 6-phosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    glucose-6-phosphate transport IEA
    Inferred from Electronic Annotation
    more info
     
    glucose-6-phosphate transport ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    glycogen catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    glycogen catabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    glycogen metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    lipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    phosphate-containing compound metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphorylated carbohydrate dephosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to food IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    steroid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    triglyceride metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    triglyceride metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    urate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    urate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    integral component of endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    glucose-6-phosphatase
    Names
    G-6-Pase
    NP_037230.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013098.2NP_037230.2  glucose-6-phosphatase

      See identical proteins and their annotated locations for NP_037230.2

      Status: VALIDATED

      Source sequence(s)
      BC090067
      UniProtKB/Swiss-Prot
      P43428
      Related
      ENSRNOP00000028033.4, OTTRNOP00000000633, ENSRNOT00000028033.6, OTTRNOT00000001213
      Conserved Domains (2) summary
      COG0671
      Location:39192
      PgpB; Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]
      cd03381
      Location:42280
      PAP2_glucose_6_phosphatase; PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts glucose-6-phosphate into free glucose and is active in the lumen of the endoplasmic reticulum, where it is bound to the membrane. The generation of free glucose is an ...

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

      Range
      89286009..89296213
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000078.1 Alternate Rn_Celera

      Range
      85025492..85036580
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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