Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Slc2a4 solute carrier family 2 member 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25139, updated on 11-Jun-2017
    Official Symbol
    Slc2a4provided by RGD
    Official Full Name
    solute carrier family 2 member 4provided by RGD
    Primary source
    RGD:2711
    See related
    Ensembl:ENSRNOG00000017226
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Glut4
    Summary
    transports glucose; may play a role in insulin response [RGD, Feb 2006]
    Orthologs
    Location:
    10q24
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56552921..56558562, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (56298102..56303687, complement)

    Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene G protein pathway suppressor 2 Neighboring gene eukaryotic translation initiation factor 5A Neighboring gene Y box binding protein 2 Neighboring gene cofilin-1-like Neighboring gene claudin 7

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC93607

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    D-glucose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glucose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glucose transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glucose transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    amylopectin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    amylopectin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    brown fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    brown fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to hypoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to insulin stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to insulin stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to osmotic stress IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to osmotic stress ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to tumor necrosis factor IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
     
    glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    glucose import IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glucose import in response to insulin stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    glucose import in response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    glucose transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    glucose transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glucose transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glucose transport ISO
    Inferred from Sequence Orthology
    more info
     
    response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    T-tubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    clathrin-coated pit IDA
    Inferred from Direct Assay
    more info
    PubMed 
    clathrin-coated vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endomembrane system ISO
    Inferred from Sequence Orthology
    more info
     
    endomembrane system ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endosome ISO
    Inferred from Sequence Orthology
    more info
     
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    insulin-responsive compartment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    insulin-responsive compartment ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    multivesicular body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    sarcolemma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sarcolemma ISO
    Inferred from Sequence Orthology
    more info
     
    trans-Golgi network transport vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    trans-Golgi network transport vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    solute carrier family 2, facilitated glucose transporter member 4
    Names
    GLUT-4
    Glucose transporter 4, insuline-responsive
    glucose transporter type 4, insulin-responsive
    insulin responsive glucose transporter
    solute carrier family 2 (facilitated glucose transporter), member 4
    solute carrier family 2 , member 4

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012751.1NP_036883.1  solute carrier family 2, facilitated glucose transporter member 4

      See identical proteins and their annotated locations for NP_036883.1

      Status: PROVISIONAL

      Source sequence(s)
      D28561
      UniProtKB/Swiss-Prot
      P19357
      Related
      ENSRNOP00000023256.3, ENSRNOT00000023256.5
      Conserved Domains (2) summary
      cd06174
      Location:78447
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam00083
      Location:27483
      Sugar_tr; Sugar (and other) transporter

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

      Range
      56552921..56558562 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246596.3XP_006246658.1  solute carrier family 2, facilitated glucose transporter member 4 isoform X1

      See identical proteins and their annotated locations for XP_006246658.1

      UniProtKB/Swiss-Prot
      P19357
      Conserved Domains (2) summary
      cd06174
      Location:78447
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam00083
      Location:27483
      Sugar_tr; Sugar (and other) transporter

    Alternate Rn_Celera

    Genomic

    1. AC_000078.1 Alternate Rn_Celera

      Range
      53819953..53825446 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center