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    RAN RAN, member RAS oncogene family [ Homo sapiens (human) ]

    Gene ID: 5901, updated on 20-Feb-2018
    Official Symbol
    RANprovided by HGNC
    Official Full Name
    RAN, member RAS oncogene familyprovided by HGNC
    Primary source
    HGNC:HGNC:9846
    See related
    Ensembl:ENSG00000132341 MIM:601179; Vega:OTTHUMG00000134328
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TC4; Gsp1; ARA24
    Summary
    RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in lymph node (RPKM 71.4), testis (RPKM 70.1) and 25 other tissues See more
    Orthologs
    Location:
    12q24.33
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 12 NC_000012.12 (130871879..130877678)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (131356617..131362220)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene syntaxin 2 Neighboring gene RNA, U6 small nuclear 1077, pseudogene Neighboring gene adhesion G protein-coupled receptor D1 Neighboring gene ADGRD1 antisense RNA 1 Neighboring gene uncharacterized LOC107984452

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify GTP binding protein RAN (RanGTP), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify GTP binding protein RAN (RanGTP), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify GTP binding protein RAN (RanGTP), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify GTP binding protein RAN (RanGTP), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    gag Ran terminates the nuclear import of the Matrix protein of HIV-1 Gag by directly binding to karyopherin beta and disassembling the import complex PubMed
    Rev rev the GTP bound form of Ran (RanGTP) binds to a preformed Rev-CRM1 (exportin 1) complex to mediate nuclear export of HIV-1 mRNA PubMed
    rev A dimeric CRM1-RanGTP complex binds a Rev-RRE complex to export the Rev-RRE complex from the nuclear to the cytoplasm in cells PubMed
    rev HIV-1 Rev interacting protein, RAN, is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
    rev Rev-Rev interactions (multimerization) are enhanced by RanGTP PubMed
    rev binding of the GTP bound form of Ran (RanGTP) to a preformed Rev-CRM1 complex is linked to an interaction of RanGTP with the nuclear export signal (NES) of Rev (amino acids 75-83) PubMed
    Tat tat Interaction of HIV-1 Tat with RAN in T-cells is identified by a proteomic strategy based on affinity chromatography PubMed
    capsid gag RanGTP inhibits the ability of TNPO3 to stimulate the uncoating of HIV-1 CA cores PubMed
    integrase gag-pol The binding between HIV-1 IN and TNPO3 is inhibited by RanGTP in a dose-dependent manner, leading to a TNPO3-RanGTP complex formation PubMed
    matrix gag Ran terminates the nuclear import of HIV-1 Matrix by directly binding to karyopherin beta and disassembling the import complex PubMed

    Go to the HIV-1, Human Interaction Database

    • Androgen receptor signaling pathway, organism-specific biosystem (from WikiPathways)
      Androgen receptor signaling pathway, organism-specific biosystemAndrogens, mainly testosterone and 5alpha-dihydrotestosterone (DHT) play significant role in the growth and development of the male reproductive organs. These steroid hormones bring about their biolo...
    • Aurora A signaling, organism-specific biosystem (from Pathway Interaction Database)
      Aurora A signaling, organism-specific biosystem
      Aurora A signaling
    • Canonical NF-kappaB pathway, organism-specific biosystem (from Pathway Interaction Database)
      Canonical NF-kappaB pathway, organism-specific biosystem
      Canonical NF-kappaB pathway
    • Disease, organism-specific biosystem (from REACTOME)
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    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Export of Viral Ribonucleoproteins from Nucleus, organism-specific biosystem (from REACTOME)
      Export of Viral Ribonucleoproteins from Nucleus, organism-specific biosystemInfluenza genomic RNA (vRNA), synthesized in the nucleus of the infected host cell, is packaged into ribonucleoprotein (RNP) complexes containing viral polymerase proteins and NP (nucleocapsid). NP ...
    • FoxO family signaling, organism-specific biosystem (from Pathway Interaction Database)
      FoxO family signaling, organism-specific biosystem
      FoxO family signaling
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Gene Silencing by RNA, organism-specific biosystem (from REACTOME)
      Gene Silencing by RNA, organism-specific biosystemIn this module, the biology of various types of regulatory non-coding RNAs are described. Currently, biogenesis and functions of small interfering RNAs (siRNAs) and microRNAs are annotated.
    • HIV Infection, organism-specific biosystem (from REACTOME)
      HIV Infection, organism-specific biosystemThe global pandemic of Human Immunodeficiency Virus (HIV) infection has resulted in tens of millions of people infected by the virus and millions more affected. UNAIDS estimates around 40 million ...
    • HIV Life Cycle, organism-specific biosystem (from REACTOME)
      HIV Life Cycle, organism-specific biosystemThe life cycle of HIV-1 is divided into early and late phases, shown schematically in the figure. In the early phase, an HIV-1 virion binds to receptors and co-receptors on the human host cell surfac...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Host Interactions of HIV factors, organism-specific biosystem (from REACTOME)
      Host Interactions of HIV factors, organism-specific biosystemLike all viruses, HIV-1 must co-opt the host cell macromolecular transport and processing machinery. HIV-1 Vpr and Rev proteins play key roles in this co-optation. Efficient HIV-1 replication likewis...
    • Infectious disease, organism-specific biosystem (from REACTOME)
      Infectious disease, organism-specific biosystem
      Infectious disease
    • Influenza Infection, organism-specific biosystem (from REACTOME)
      Influenza Infection, organism-specific biosystemFor centuries influenza epidemics have plagued man, and influenza was probably the disease described by Hippocrates in 412 BC. Today it remains a major cause of morbidity and mortality worldwide with...
    • Influenza Life Cycle, organism-specific biosystem (from REACTOME)
      Influenza Life Cycle, organism-specific biosystemThe virus particle initially associates with a human host cell by binding to sialic acid-containing receptors on the host cell surface. The bound virus is endocytosed by one of four distinct mechanis...
    • Interactions of Rev with host cellular proteins, organism-specific biosystem (from REACTOME)
      Interactions of Rev with host cellular proteins, organism-specific biosystemIn order to facilitate the transport of incompletely spliced HIV-1 transcripts, Rev shuttles between the cytoplasm and nucleus using host cell transport mechanisms (reviewed in Li et al. 2005). Nucl...
    • Late Phase of HIV Life Cycle, organism-specific biosystem (from REACTOME)
      Late Phase of HIV Life Cycle, organism-specific biosystemThe late phase of the HIV-1 life cycle includes the regulated expression of the HIV gene products and the assembly of viral particles. The assembly of viral particles will be covered in a later relea...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • MicroRNA (miRNA) biogenesis, organism-specific biosystem (from REACTOME)
      MicroRNA (miRNA) biogenesis, organism-specific biosystemBiogenesis of microRNAs (miRNAs) can be summarized in five steps (reviewed in Ketting 2011, Nowotny and Yang 2009, Kim et al. 2009, Chua et al. 2009, Hannon and He 2004):1. Transcription. miRNA trans...
    • NEP/NS2 Interacts with the Cellular Export Machinery, organism-specific biosystem (from REACTOME)
      NEP/NS2 Interacts with the Cellular Export Machinery, organism-specific biosystemThe viral RNP complex is exported from the nucleus via the host cell CRM1 export pathway (Fukuda, 1997; Neumann, 2000; reviewed in Buolo, 2006). The vRNP complex does not interact directly with CRM1 ...
    • Nuclear import of Rev protein, organism-specific biosystem (from REACTOME)
      Nuclear import of Rev protein, organism-specific biosystemNuclear import of Rev involves the cellular proteins including importin-beta and B23 and is mediated by an arginine-rich nuclear localization signal (NLS) within the RNA binding domain of the Rev pr...
    • RNA transport, organism-specific biosystem (from KEGG)
      RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • RNA transport, conserved biosystem (from KEGG)
      RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • Regulation of cholesterol biosynthesis by SREBP (SREBF), organism-specific biosystem (from REACTOME)
      Regulation of cholesterol biosynthesis by SREBP (SREBF), organism-specific biosystemSterol regulatory element binding proteins (SREBPs, SREBFs) respond to low cholesterol concentrations by transiting to the nucleus and activating genes involved in cholesterol and lipid biosynthesis ...
    • Rev-mediated nuclear export of HIV RNA, organism-specific biosystem (from REACTOME)
      Rev-mediated nuclear export of HIV RNA, organism-specific biosystemThe HIV-1 genome contains 9 genes encoded by a single transcript. In order for the virus to replicate, unspliced, singly-spliced and fully spliced viral mRNA must be exported from the nucleus. The H...
    • Ribosome biogenesis in eukaryotes, organism-specific biosystem (from KEGG)
      Ribosome biogenesis in eukaryotes, organism-specific biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
    • Ribosome biogenesis in eukaryotes, conserved biosystem (from KEGG)
      Ribosome biogenesis in eukaryotes, conserved biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
    • Role of Calcineurin-dependent NFAT signaling in lymphocytes, organism-specific biosystem (from Pathway Interaction Database)
      Role of Calcineurin-dependent NFAT signaling in lymphocytes, organism-specific biosystem
      Role of Calcineurin-dependent NFAT signaling in lymphocytes
    • Signaling events mediated by HDAC Class I, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by HDAC Class I, organism-specific biosystem
      Signaling events mediated by HDAC Class I
    • Signaling events mediated by HDAC Class II, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by HDAC Class II, organism-specific biosystem
      Signaling events mediated by HDAC Class II
    • Sumoylation by RanBP2 regulates transcriptional repression, organism-specific biosystem (from Pathway Interaction Database)
      Sumoylation by RanBP2 regulates transcriptional repression, organism-specific biosystem
      Sumoylation by RanBP2 regulates transcriptional repression
    • Transcriptional regulation by small RNAs, organism-specific biosystem (from REACTOME)
      Transcriptional regulation by small RNAs, organism-specific biosystemRecent evidence indicates that small RNAs participate in transcriptional regulation in addition to post-transcriptional silencing. Components of the RNAi machinery (ARGONAUTE1 (AGO1, EIF2C1), AGO2 (E...
    • miRNA Biogenesis, organism-specific biosystem (from WikiPathways)
      miRNA Biogenesis, organism-specific biosystemmicroRNA biogenesis + an example of a miRBase entry. As an example immature hsa-mir-146a is shown
    • tRNA processing, organism-specific biosystem (from REACTOME)
      tRNA processing, organism-specific biosystemGenes encoding transfer RNAs (tRNAs) are transcribed by RNA polymerase III in the nucleus and by mitochondrial RNA polymerase in the mitochondrion.In the nucleus transcription reactions produce precu...
    • tRNA processing in the nucleus, organism-specific biosystem (from REACTOME)
      tRNA processing in the nucleus, organism-specific biosystemGenes encoding transfer RNAs are transcribed in the nucleus by RNA polymerase III. (Distinct processes of transcription and processing also occur in mitochondria.) The initial transcripts, pre-tRNAs,...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GDP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GDP binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTP binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTPase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    RNA binding HDA PubMed 
    androgen receptor binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cadherin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    dynein intermediate chain binding IEA
    Inferred from Electronic Annotation
    more info
     
    importin-alpha family protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to nucleocytoplasmic carrier activity IC
    Inferred by Curator
    more info
    PubMed 
    contributes_to pre-miRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription coactivator activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    GTP metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    androgen receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cellular protein-containing complex localization IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to mineralocorticoid stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    hippocampus development IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular transport of virus TAS
    Traceable Author Statement
    more info
     
    miRNA metabolic process TAS
    Traceable Author Statement
    more info
     
    mitotic cell cycle TAS
    Traceable Author Statement
    more info
    PubMed 
    mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic spindle organization TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated NAS
    Non-traceable Author Statement
    more info
    PubMed 
    pre-miRNA export from nucleus IC
    Inferred by Curator
    more info
    PubMed 
    protein export from nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein import into nucleus, translocation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization to nucleolus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cholesterol biosynthetic process TAS
    Traceable Author Statement
    more info
     
    regulation of gene silencing by miRNA TAS
    Traceable Author Statement
    more info
     
    ribosomal large subunit export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ribosomal small subunit export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    snRNA import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spermatid development IEA
    Inferred from Electronic Annotation
    more info
     
    tRNA export from nucleus TAS
    Traceable Author Statement
    more info
     
    viral process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    NOT Flemming body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA nuclear export complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centriole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome HDA PubMed 
    extracellular matrix HDA PubMed 
    host cell IEA
    Inferred from Electronic Annotation
    more info
     
    male germ cell nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    manchette IEA
    Inferred from Electronic Annotation
    more info
     
    melanosome IEA
    Inferred from Electronic Annotation
    more info
     
    membrane HDA PubMed 
    midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear pore NAS
    Non-traceable Author Statement
    more info
    PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus HDA PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    recycling endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sperm flagellum IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    GTP-binding nuclear protein Ran
    Names
    GTPase Ran
    OK/SW-cl.81
    RanGTPase
    androgen receptor-associated protein 24
    guanosine triphosphatase Ran
    member RAS oncogene family
    ras-like protein TC4
    ras-related nuclear protein
    NP_001287725.1
    NP_001287726.1
    NP_006316.1
    XP_016875261.1
    XP_016875262.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001300796.1NP_001287725.1  GTP-binding nuclear protein Ran isoform 2

      See identical proteins and their annotated locations for NP_001287725.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same protein.
      Source sequence(s)
      AC073912, AF054183, AK316193, HY139187, HY336901
      Consensus CDS
      CCDS73546.1
      UniProtKB/Swiss-Prot
      P62826
      UniProtKB/TrEMBL
      B4DV51
      Related
      ENSP00000441210.1, OTTHUMP00000238587, ENST00000541630.5, OTTHUMT00000399320
      Conserved Domains (1) summary
      cl27030
      Location:1127
      Ras; Ras family
    2. NM_001300797.1NP_001287726.1  GTP-binding nuclear protein Ran isoform 2

      See identical proteins and their annotated locations for NP_001287726.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same protein.
      Source sequence(s)
      AC073912, AK300934, HY139187, HY336901
      Consensus CDS
      CCDS73546.1
      UniProtKB/Swiss-Prot
      P62826
      UniProtKB/TrEMBL
      B4DV51
      Conserved Domains (1) summary
      cl27030
      Location:1127
      Ras; Ras family
    3. NM_006325.4NP_006316.1  GTP-binding nuclear protein Ran isoform 1

      See identical proteins and their annotated locations for NP_006316.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC073912, AF054183, BC000852, HY336901
      Consensus CDS
      CCDS9271.1
      UniProtKB/Swiss-Prot
      P62826
      Related
      ENSP00000446215.1, OTTHUMP00000166077, ENST00000543796.5, OTTHUMT00000259441
      Conserved Domains (1) summary
      smart00176
      Location:16215
      RAN; Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p7 Primary Assembly

      Range
      130871879..130877678
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017019772.1XP_016875261.1  GTP-binding nuclear protein Ran isoform X1

      Related
      ENSP00000444042.1, OTTHUMP00000238588, ENST00000535090.5, OTTHUMT00000399321
    2. XM_017019773.1XP_016875262.1  GTP-binding nuclear protein Ran isoform X2

    Alternate CHM1_1.1

    Genomic

    1. NC_018923.2 Alternate CHM1_1.1

      Range
      131177300..131182984
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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