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    TPX2 TPX2, microtubule nucleation factor [ Homo sapiens (human) ]

    Gene ID: 22974, updated on 15-May-2017
    Official Symbol
    TPX2provided by HGNC
    Official Full Name
    TPX2, microtubule nucleation factorprovided by HGNC
    Primary source
    HGNC:HGNC:1249
    See related
    Ensembl:ENSG00000088325 MIM:605917; Vega:OTTHUMG00000032190
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DIL2; p100; DIL-2; HCTP4; FLS353; HCA519; REPP86; C20orf1; C20orf2; GD:C20orf1
    Orthologs
    Location:
    20q11.21
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 20 NC_000020.11 (31739101..31801802)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (30326904..30389605)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372589 Neighboring gene BCL2 like 1 Neighboring gene apoptotic BCL2L1-antisense long non-coding RNA Neighboring gene myosin light chain kinase 2 Neighboring gene dual specificity phosphatase 15 Neighboring gene forkhead box S1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • AURKA Activation by TPX2, organism-specific biosystem (from REACTOME)
      AURKA Activation by TPX2, organism-specific biosystemTPX2 binds to aurora kinase A (AURKA) at centrosomes and promotes its activation by facilitating AURKA active conformation and autophosphorylation of the AURKA threonine residue T288 (Bayliss et al. ...
    • Aurora A signaling, organism-specific biosystem (from Pathway Interaction Database)
      Aurora A signaling, organism-specific biosystem
      Aurora A signaling
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • G2/M Transition, organism-specific biosystem (from REACTOME)
      G2/M Transition, organism-specific biosystemCyclin A can also form complexes with Cdc2 (Cdk1). Together with three B-type cyclins, Cdc2 (Cdk1) regulates the transition from G2 into mitosis. These complexes are activated by dephosphorylation of...
    • Gastric Cancer Network 1, organism-specific biosystem (from WikiPathways)
      Gastric Cancer Network 1, organism-specific biosystemNetwork generated by mapping candidate oncogenes and tumor suppressor genes identified by integrated analysis of expression array and aCGH data. Networks generated by Ingenuity Pathway Analysis.
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
    • Mitotic G2-G2/M phases, organism-specific biosystem (from REACTOME)
      Mitotic G2-G2/M phases, organism-specific biosystem
      Mitotic G2-G2/M phases
    • PLK1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      PLK1 signaling events, organism-specific biosystem
      PLK1 signaling events
    • Regulation of TP53 Activity, organism-specific biosystem (from REACTOME)
      Regulation of TP53 Activity, organism-specific biosystemProtein stability and transcriptional activity of TP53 (p53) tumor suppressor are regulated by post-translational modifications that include ubiquitination, phosphorylation, acetylation, methylation,...
    • Regulation of TP53 Activity through Phosphorylation, organism-specific biosystem (from REACTOME)
      Regulation of TP53 Activity through Phosphorylation, organism-specific biosystemPhosphorylation of TP53 (p53) at the N-terminal serine residues S15 and S20 plays a critical role in protein stabilization as phosphorylation at these sites interferes with binding of the ubiquitin l...
    • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
      Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding TAS
    Traceable Author Statement
    more info
    PubMed 
    GTP binding TAS
    Traceable Author Statement
    more info
    PubMed 
    importin-alpha family protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    G2/M transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
     
    activation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    mitotic cell cycle TAS
    Traceable Author Statement
    more info
    PubMed 
    mitotic spindle assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of mitotic spindle organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    regulation of signal transduction by p53 class mediator TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    axon hillock IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    mitotic spindle IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    spindle ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    colocalizes_with spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    targeting protein for Xklp2
    Names
    TPX2, microtubule-associated protein homolog
    TPX2, microtubule-associated, homolog
    differentially expressed in cancerous and non-cancerous lung cells 2
    differentially expressed in lung cells
    hepatocellular carcinoma-associated antigen 519
    hepatocellular carcinoma-associated antigen 90
    preferentially expressed in colorectal cancer
    protein fls353
    restricted expression proliferation associated protein 100

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012112.4NP_036244.2  targeting protein for Xklp2

      See identical proteins and their annotated locations for NP_036244.2

      Status: VALIDATED

      Source sequence(s)
      AF098158, BC020207, BM835456, BU181208, CB960160
      Consensus CDS
      CCDS13190.1
      UniProtKB/Swiss-Prot
      Q9ULW0
      UniProtKB/TrEMBL
      Q643R0
      Related
      ENSP00000300403.6, OTTHUMP00000030547, ENST00000300403.10, OTTHUMT00000078569
      Conserved Domains (3) summary
      pfam06886
      Location:664718
      TPX2; Targeting protein for Xklp2 (TPX2)
      pfam09041
      Location:168
      Aurora-A_bind; Aurora-A binding
      pfam12214
      Location:367489
      TPX2_importin; Cell cycle regulated microtubule associated protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p7 Primary Assembly

      Range
      31739101..31801802
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011528699.2XP_011527001.1  targeting protein for Xklp2 isoform X1

      See identical proteins and their annotated locations for XP_011527001.1

      UniProtKB/Swiss-Prot
      Q9ULW0
      UniProtKB/TrEMBL
      Q643R0
      Conserved Domains (3) summary
      pfam06886
      Location:664718
      TPX2; Targeting protein for Xklp2 (TPX2)
      pfam09041
      Location:168
      Aurora-A_bind; Aurora-A binding
      pfam12214
      Location:367489
      TPX2_importin; Cell cycle regulated microtubule associated protein
    2. XM_011528697.2XP_011526999.1  targeting protein for Xklp2 isoform X1

      See identical proteins and their annotated locations for XP_011526999.1

      UniProtKB/Swiss-Prot
      Q9ULW0
      UniProtKB/TrEMBL
      Q643R0
      Conserved Domains (3) summary
      pfam06886
      Location:664718
      TPX2; Targeting protein for Xklp2 (TPX2)
      pfam09041
      Location:168
      Aurora-A_bind; Aurora-A binding
      pfam12214
      Location:367489
      TPX2_importin; Cell cycle regulated microtubule associated protein
    3. XM_011528700.2XP_011527002.1  targeting protein for Xklp2 isoform X2

      Conserved Domains (3) summary
      pfam06886
      Location:657711
      TPX2; Targeting protein for Xklp2 (TPX2)
      pfam09041
      Location:168
      Aurora-A_bind; Aurora-A binding
      pfam12214
      Location:367489
      TPX2_importin; Cell cycle regulated microtubule associated protein

    Alternate CHM1_1.1

    Genomic

    1. NC_018931.2 Alternate CHM1_1.1

      Range
      30230786..30293470
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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