Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    BCL2L1 BCL2 like 1 [ Homo sapiens (human) ]

    Gene ID: 598, updated on 21-May-2017
    Official Symbol
    BCL2L1provided by HGNC
    Official Full Name
    BCL2 like 1provided by HGNC
    Primary source
    HGNC:HGNC:992
    See related
    Ensembl:ENSG00000171552 MIM:600039; Vega:OTTHUMG00000032192
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BCLX; BCL2L; Bcl-X; PPP1R52; BCL-XL/S
    Summary
    The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. [provided by RefSeq, Dec 2015]
    Orthologs
    Location:
    20q11.21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 20 NC_000020.11 (31664452..31723999, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (30252261..30311752, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene microRNA 3193 Neighboring gene cytochrome c oxidase subunit 4I2 Neighboring gene uncharacterized LOC105372589 Neighboring gene apoptotic BCL2L1-antisense long non-coding RNA Neighboring gene TPX2, microtubule nucleation factor Neighboring gene myosin light chain kinase 2

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Treatment of monocyte-derived dendritic cells with HIV-1 gp120 downregulates the expression of the anti-apoptotic molecules BCL-2 and BCL-xL PubMed
    env Treatment of cells with dsRNA against 14-3-3tau enhances gp120-mediated dephosphorylation of Bad and its association with Bcl-XL in mitochondria, and accelerates gp120-induced apoptosis PubMed
    Envelope surface glycoprotein gp160, precursor env Treatment of CD4+ cells with HIV-1 gp160 causes intracellular calcium increase followed by the release of cytochrome c from mitochondria; association of BAD with Bcl-xL is observed, and a portion of BAD is dephosphorylated after gp160 induction PubMed
    Nef nef HIV-1 Nef enhances apoptosis in CD4+ human lymphoblastoid cell lines through mechanisms that include the downregulation of the anti-apoptotic proteins Bcl-2 and Bcl-XL PubMed
    nef HIV-1 Nef suppresses apoptosis of TF-1 macrophages by upregulating mitochondrial anti-apoptosis protein Bcl-XL expression; cell survival and Bcl-XL induction by Nef are dependent on the Erk/MAPK pathway, but independent of PI3K and Akt activation PubMed
    Tat tat HIV-1 Tat upregulates several anti-apoptotic genes, including AKT-1, AKT-2, BCL2, BCL-XL, and insulin-like growth factor I in vincristine-treated Kaposi's sarcoma cells PubMed
    Vpr vpr Bcl-xL and MCL-1 play a critical role in macrophage survival but not in resistance to HIV-1 Vpr-induced apoptosis PubMed
    vpr HIV-1 Vpr induces downregulation of the Bcl-xl protein, upregulation of the Bax protein, and the cytochrome c release from the mitochondria in multidrug-resistant human colorectal cancer cells PubMed
    vpr Expression of HIV-1 Vpr causes redistribution of Bcl-X protein into an organized, network-like manner to form filamentous structures PubMed
    vpr HIV-1 Vpr downregulated Bcl-X expression in transgenic mice suggesting a role in Vpr mediated apoptosis of T lymphocytes PubMed
    Vpu vpu Levels of Bcl-xL are reduced in T cells as a result of HIV-1 Vpu-mediated inhibition of NF-kappa B activation PubMed
    nucleocapsid gag HIV-1 NC downregulates BCL2-like 1 in HEK 293T cells PubMed

    Go to the HIV-1, Human Interaction Database

    • Amyotrophic lateral sclerosis (ALS), organism-specific biosystem (from KEGG)
      Amyotrophic lateral sclerosis (ALS), organism-specific biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
    • Amyotrophic lateral sclerosis (ALS), organism-specific biosystem (from WikiPathways)
      Amyotrophic lateral sclerosis (ALS), organism-specific biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
    • Amyotrophic lateral sclerosis (ALS), conserved biosystem (from KEGG)
      Amyotrophic lateral sclerosis (ALS), conserved biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
    • Apoptosis, organism-specific biosystem (from KEGG)
      Apoptosis, organism-specific biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
    • Apoptosis, organism-specific biosystem (from WikiPathways)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptosis, conserved biosystem (from KEGG)
      Apoptosis, conserved biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
    • Apoptosis, organism-specific biosystem (from REACTOME)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptosis - multiple species, organism-specific biosystem (from KEGG)
      Apoptosis - multiple species, organism-specific biosystemApoptosis is an evolutionarily conserved process used by multicellular organisms to developmentally regulate cell number or to eliminate cells that are potentially detrimental to the organism. The ma...
    • Apoptosis - multiple species, conserved biosystem (from KEGG)
      Apoptosis - multiple species, conserved biosystemApoptosis is an evolutionarily conserved process used by multicellular organisms to developmentally regulate cell number or to eliminate cells that are potentially detrimental to the organism. The ma...
    • Apoptosis Modulation and Signaling, organism-specific biosystem (from WikiPathways)
      Apoptosis Modulation and Signaling, organism-specific biosystemApoptosis, or cell death program, can be activated by various mechanisms within the extrinsic and the intrinsic pathway. While activation of cell death receptors leads to the engagement of the extrin...
    • Autophagy - animal, organism-specific biosystem (from KEGG)
      Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Autophagy - animal, conserved biosystem (from KEGG)
      Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members, organism-specific biosystem (from REACTOME)
      BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members, organism-specific biosystem
      BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
    • Chronic myeloid leukemia, organism-specific biosystem (from KEGG)
      Chronic myeloid leukemia, organism-specific biosystemChronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of a pluripotent stem cell. The natural history of CML has a triphasic clinical course comprising of an initial chronic phase (C...
    • Chronic myeloid leukemia, conserved biosystem (from KEGG)
      Chronic myeloid leukemia, conserved biosystemChronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of a pluripotent stem cell. The natural history of CML has a triphasic clinical course comprising of an initial chronic phase (C...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • EGFR tyrosine kinase inhibitor resistance, organism-specific biosystem (from KEGG)
      EGFR tyrosine kinase inhibitor resistance, organism-specific biosystemEGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis. EGFR also serves as a stimulus for cancer growth. EGFR gene mutations and protein overexpression, both of which ...
    • EGFR tyrosine kinase inhibitor resistance, conserved biosystem (from KEGG)
      EGFR tyrosine kinase inhibitor resistance, conserved biosystemEGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis. EGFR also serves as a stimulus for cancer growth. EGFR gene mutations and protein overexpression, both of which ...
    • EPO signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      EPO signaling pathway, organism-specific biosystem
      EPO signaling pathway
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Hematopoietic Stem Cell Gene Regulation by GABP alpha/beta Complex, organism-specific biosystem (from WikiPathways)
      Hematopoietic Stem Cell Gene Regulation by GABP alpha/beta Complex, organism-specific biosystemGABP alpha/beta complex mediates the maintenance of hematopoietic stem cells (HSCs) through control of proteins necessary for epigenetic modification and transcription regulation. The activation of k...
    • Hepatitis C and Hepatocellular Carcinoma, organism-specific biosystem (from WikiPathways)
      Hepatitis C and Hepatocellular Carcinoma, organism-specific biosystemPathway model based on hub miRNAs and their putative targets from network analysis. - From a set of differentially expressed genes in both chronic HCV (hepatitis C virus) and HCC (hepatocellular carc...
    • IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-3 Signaling Pathway, organism-specific biosystemInterleukin 3 (IL-3) is a potent growth factor belonging to the super family of cytokines. IL-3 is a 20- 32kDa glycoprotein involved in the process of hematopoiesis. It is involved in the proliferati...
    • IL-6 signaling pathway, organism-specific biosystem (from WikiPathways)
      IL-6 signaling pathway, organism-specific biosystemIL-6 is a pleiotropic cytokine with important role in immune regulation, hematopoiesis, inflammation and oncogenesis. IL-6-type cytokines exert their action via the signal transducer gp130 that assoc...
    • IL-7 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-7 Signaling Pathway, organism-specific biosystemInterleukin-7 (IL-7) was discovered in the year 1988 as a factor that enhanced the growth of murine B-cell precursors in bone marrow culture system. It was also known as lymphopoietin 1and pre-B cell...
    • IL2 signaling events mediated by PI3K, organism-specific biosystem (from Pathway Interaction Database)
      IL2 signaling events mediated by PI3K, organism-specific biosystem
      IL2 signaling events mediated by PI3K
    • IL2 signaling events mediated by STAT5, organism-specific biosystem (from Pathway Interaction Database)
      IL2 signaling events mediated by STAT5, organism-specific biosystem
      IL2 signaling events mediated by STAT5
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Inflammasomes, organism-specific biosystem (from REACTOME)
      Inflammasomes, organism-specific biosystemIn contrast to NOD1/2 some NLRPs function as large macromolecular complexes called 'Inflammasomes'. These multiprotein platforms control activation of the cysteinyl aspartate protease caspase-1 and t...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Interleukin-4 and 13 signaling, organism-specific biosystem (from REACTOME)
      Interleukin-4 and 13 signaling, organism-specific biosystemInterleukin-4 (IL4) is a principal regulatory cytokine during the immune response, crucially important in allergy and asthma (Nelms et al. 1999). When resting T cells are antigen-activated and expand...
    • Intrinsic Pathway for Apoptosis, organism-specific biosystem (from REACTOME)
      Intrinsic Pathway for Apoptosis, organism-specific biosystemThe intrinsic (Bcl-2 inhibitable or mitochondrial) pathway of apoptosis functions in response to various types of intracellular stress including growth factor withdrawal, DNA damage, unfolding stress...
    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
      Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
      Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Leptin signaling pathway, organism-specific biosystem (from WikiPathways)
      Leptin signaling pathway, organism-specific biosystemLeptin is a peptide hormone mainly synthesised and secreted from adipocytes. It is also expressed in other tissues including placenta, stomach and skeletal muscle. Leptin mediates its effects by bind...
    • LncRNA-mediated mechanisms of therapeutic resistance, organism-specific biosystem (from WikiPathways)
      LncRNA-mediated mechanisms of therapeutic resistance, organism-specific biosystemLncRNA-mediated mechanisms of therapeutic resistance. Mechanisms of tumor cell resistance to chemotherapy or hypoxia involving lncRNA include modulation of drug transporters and elimination, survival...
    • Mitophagy - animal, organism-specific biosystem (from KEGG)
      Mitophagy - animal, organism-specific biosystemMitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process calle...
    • Mitophagy - animal, conserved biosystem (from KEGG)
      Mitophagy - animal, conserved biosystemMitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process calle...
    • NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
      NF-kappa B signaling pathway, organism-specific biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
    • NF-kappa B signaling pathway, conserved biosystem (from KEGG)
      NF-kappa B signaling pathway, conserved biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
    • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
      NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • Nanomaterial induced apoptosis, organism-specific biosystem (from WikiPathways)
      Nanomaterial induced apoptosis, organism-specific biosystemApotosis caused by nanomaterials, such as single-walled carbon nanohorns, titanium oxide, and polystyrene nanoparticles, may be induced through lysosomal impairment. For example, PAMAMs have been fou...
    • Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystem (from REACTOME)
      Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystemThe innate immune system is the first line of defense against invading microorganisms, a broad specificity response characterized by the recruitment and activation of phagocytes and the release of an...
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • Pancreatic cancer, organism-specific biosystem (from KEGG)
      Pancreatic cancer, organism-specific biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pancreatic cancer, conserved biosystem (from KEGG)
      Pancreatic cancer, conserved biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Photodynamic therapy-induced AP-1 survival signaling., organism-specific biosystem (from WikiPathways)
      Photodynamic therapy-induced AP-1 survival signaling., organism-specific biosystemPhotodynamic therapy may induce an acute stress response mediated by mitogen-activated protein kinase kinase kinase 5 (MAP3K5), its downstream MAPKs that target c-Jun N-terminal kinase (JNK, MAPK8) a...
    • Photodynamic therapy-induced HIF-1 survival signaling, organism-specific biosystem (from WikiPathways)
      Photodynamic therapy-induced HIF-1 survival signaling, organism-specific biosystemPhotodynamic therapy may induce a hypoxic survival response mediated by HIF-1.
    • Platinum drug resistance, organism-specific biosystem (from KEGG)
      Platinum drug resistance, organism-specific biosystemPlatinum-based drugs cisplatin, carboplatin and oxaliplatin are widely used in the therapy of solid malignancies, including testicular, ovarian, head and neck, colorectal, bladder and lung cancers. T...
    • Platinum drug resistance, conserved biosystem (from KEGG)
      Platinum drug resistance, conserved biosystemPlatinum-based drugs cisplatin, carboplatin and oxaliplatin are widely used in the therapy of solid malignancies, including testicular, ovarian, head and neck, colorectal, bladder and lung cancers. T...
    • Programmed Cell Death, organism-specific biosystem (from REACTOME)
      Programmed Cell Death, organism-specific biosystemCell death is a fundamental cellular response that has a crucial role in shaping our bodies during development and in regulating tissue homeostasis by eliminating unwanted cells. There are a number o...
    • Ras signaling pathway, organism-specific biosystem (from KEGG)
      Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
    • Regulation of Apoptosis by Parathyroid Hormone-related Protein, organism-specific biosystem (from WikiPathways)
      Regulation of Apoptosis by Parathyroid Hormone-related Protein, organism-specific biosystemThis pathway is based on Figure 8 of "Parathyroid hormone-related protein regulates cell survival pathways via integrin alpha6beta4-mediated activation of phosphatidylinositol 3-kinase/Akt signaling....
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
    • Small cell lung cancer, organism-specific biosystem (from KEGG)
      Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Small cell lung cancer, conserved biosystem (from KEGG)
      Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • TNF alpha Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TNF alpha Signaling Pathway, organism-specific biosystemTumor necrosis factor alpha (TNF?) is a proinflammatory cytokine involved in various biological processes including regulation of cell proliferation, differentiation, apoptosis and immune response. T...
    • The NLRP1 inflammasome, organism-specific biosystem (from REACTOME)
      The NLRP1 inflammasome, organism-specific biosystemNLRP1 is activated by MDP (Faustin et al. 2007). The NLRP1 inflammasome was the first to be characterized. It was described as a complex containing NALP1, ASC, caspase-1 and caspase-5 (Martinon et al...
    • Toxoplasmosis, organism-specific biosystem (from KEGG)
      Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Toxoplasmosis, conserved biosystem (from KEGG)
      Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
      Transcriptional misregulation in cancer, organism-specific biosystem
      Transcriptional misregulation in cancer
    • Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
      Transcriptional misregulation in cancer, conserved biosystem
      Transcriptional misregulation in cancer
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • DKFZp781P2092

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    BH3 domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    apoptotic mitochondrial changes TAS
    Traceable Author Statement
    more info
    PubMed 
    apoptotic process in bone marrow IEA
    Inferred from Electronic Annotation
    more info
     
    cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular process regulating host cell cycle in response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to alkaloid IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to amino acid stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to gamma radiation IEA
    Inferred from Electronic Annotation
    more info
     
    cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    extrinsic apoptotic signaling pathway in absence of ligand IEA
    Inferred from Electronic Annotation
    more info
     
    fertilization IEA
    Inferred from Electronic Annotation
    more info
     
    germ cell development IEA
    Inferred from Electronic Annotation
    more info
     
    growth IEA
    Inferred from Electronic Annotation
    more info
     
    hepatocyte apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    intrinsic apoptotic signaling pathway in response to DNA damage IEA
    Inferred from Electronic Annotation
    more info
     
    male gonad development IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic cell cycle checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of establishment of protein localization to plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of execution phase of apoptosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of extrinsic apoptotic signaling pathway in absence of ligand TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of intrinsic apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of release of cytochrome c from mitochondria IC
    Inferred by Curator
    more info
    PubMed 
    neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    ovarian follicle development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of intrinsic apoptotic signaling pathway TAS
    Traceable Author Statement
    more info
     
    regulation of mitochondrial membrane permeability IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of mitochondrial membrane potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    release of cytochrome c from mitochondria IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to cycloheximide IEA
    Inferred from Electronic Annotation
    more info
     
    response to cytokine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    suppression by virus of host apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    Bcl-2 family protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial outer membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    bcl-2-like protein 1
    Names
    apoptosis regulator Bcl-X
    protein phosphatase 1, regulatory subunit 52

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029002.1 RefSeqGene

      Range
      4756..63396
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001191.3NP_001182.1  bcl-2-like protein 1 isoform Bcl-X(S)

      See identical proteins and their annotated locations for NP_001182.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site, in the central coding region, compared to variant 1. The encoded isoform (Bcl-X(S), also known as Bcl-xS) is shorter than isoform Bcl-X(L).
      Source sequence(s)
      AI872556, AK290968, BC019307, BU845775
      Consensus CDS
      CCDS13188.1
      UniProtKB/Swiss-Prot
      Q07817
      UniProtKB/TrEMBL
      Q5TE63
      Related
      ENSP00000365223.4, OTTHUMP00000030551, ENST00000376055.8, OTTHUMT00000078573
      Conserved Domains (3) summary
      smart00265
      Location:127
      BH4; BH4 Bcl-2 homology region 4
      TIGR00865
      Location:1170
      bcl-2; apoptosis regulator
      cl02575
      Location:81125
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
    2. NM_001317919.1NP_001304848.1  bcl-2-like protein 1 isoform Bcl-X(L)

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 3, 4 and 5 encode the same isoform (Bcl-X(L), also known as Bcl-xL).
      Source sequence(s)
      AI872556, AL160175, BC019307, BU845775, CR936637
      Consensus CDS
      CCDS13189.1
      UniProtKB/Swiss-Prot
      Q07817
      UniProtKB/TrEMBL
      A0A0S2Z3C5
      Related
      ENSP00000411252.1, OTTHUMP00000030557, ENST00000422920.1, OTTHUMT00000078579
      Conserved Domains (3) summary
      smart00265
      Location:127
      BH4; BH4 Bcl-2 homology region 4
      cd06845
      Location:81194
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
      TIGR00865
      Location:1233
      bcl-2; apoptosis regulator
    3. NM_001317920.1NP_001304849.1  bcl-2-like protein 1 isoform Bcl-X(L)

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 3, 4 and 5 encode the same isoform (Bcl-X(L), also known as Bcl-xL).
      Source sequence(s)
      AA488236, AI872556, AL160175, BC019307, BM554265, DR156871
      Consensus CDS
      CCDS13189.1
      UniProtKB/Swiss-Prot
      Q07817
      UniProtKB/TrEMBL
      A0A0S2Z3C5
      Conserved Domains (3) summary
      smart00265
      Location:127
      BH4; BH4 Bcl-2 homology region 4
      cd06845
      Location:81194
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
      TIGR00865
      Location:1233
      bcl-2; apoptosis regulator
    4. NM_001317921.1NP_001304850.1  bcl-2-like protein 1 isoform Bcl-X(L)

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 3, 4 and 5 encode the same isoform (Bcl-X(L), also known as Bcl-xL).
      Source sequence(s)
      AA488236, AI872556, AL160175, BC019307, BM554265, BX359456
      Consensus CDS
      CCDS13189.1
      UniProtKB/Swiss-Prot
      Q07817
      UniProtKB/TrEMBL
      A0A0S2Z3C5
      Related
      ENSP00000406203.1, OTTHUMP00000030552, ENST00000450273.1, OTTHUMT00000078574
      Conserved Domains (3) summary
      smart00265
      Location:127
      BH4; BH4 Bcl-2 homology region 4
      cd06845
      Location:81194
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
      TIGR00865
      Location:1233
      bcl-2; apoptosis regulator
    5. NM_001322239.1NP_001309168.1  bcl-2-like protein 1 isoform Bcl-X(L)

      Status: REVIEWED

      Source sequence(s)
      AA488236, AI872557, AL160175, BC019307
      Consensus CDS
      CCDS13189.1
      UniProtKB/Swiss-Prot
      Q07817
      UniProtKB/TrEMBL
      A0A0S2Z3C5
      Related
      ENSP00000390760.1, OTTHUMP00000030555, ENST00000420488.5, OTTHUMT00000078577
      Conserved Domains (3) summary
      smart00265
      Location:127
      BH4; BH4 Bcl-2 homology region 4
      cd06845
      Location:81194
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
      TIGR00865
      Location:1233
      bcl-2; apoptosis regulator
    6. NM_001322240.1NP_001309169.1  bcl-2-like protein 1 isoform Bcl-X(L)

      Status: REVIEWED

      Source sequence(s)
      AA488236, AI872557, AL160175, BC019307
      Consensus CDS
      CCDS13189.1
      UniProtKB/Swiss-Prot
      Q07817
      UniProtKB/TrEMBL
      A0A0S2Z3C5
      Related
      ENSP00000395545.1, OTTHUMP00000030556, ENST00000456404.5, OTTHUMT00000078578
      Conserved Domains (3) summary
      smart00265
      Location:127
      BH4; BH4 Bcl-2 homology region 4
      cd06845
      Location:81194
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
      TIGR00865
      Location:1233
      bcl-2; apoptosis regulator
    7. NM_001322242.1NP_001309171.1  bcl-2-like protein 1 isoform Bcl-X(L)

      Status: REVIEWED

      Source sequence(s)
      AI872557, AL160175, BC019307
      Consensus CDS
      CCDS13189.1
      UniProtKB/Swiss-Prot
      Q07817
      UniProtKB/TrEMBL
      A0A0S2Z3C5
      Related
      ENSP00000365230.2, OTTHUMP00000030550, ENST00000376062.6, OTTHUMT00000078572
      Conserved Domains (3) summary
      smart00265
      Location:127
      BH4; BH4 Bcl-2 homology region 4
      cd06845
      Location:81194
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
      TIGR00865
      Location:1233
      bcl-2; apoptosis regulator
    8. NM_138578.2NP_612815.1  bcl-2-like protein 1 isoform Bcl-X(L)

      See identical proteins and their annotated locations for NP_612815.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (Bcl-X(L), also known as Bcl-xL). Variants 1, 3, 4 and 5 encode the same isoform.
      Source sequence(s)
      BC019307, BU845775
      Consensus CDS
      CCDS13189.1
      UniProtKB/Swiss-Prot
      Q07817
      UniProtKB/TrEMBL
      A0A0S2Z3C5
      Related
      ENSP00000302564.4, OTTHUMP00000030553, ENST00000307677.4, OTTHUMT00000078575
      Conserved Domains (3) summary
      smart00265
      Location:127
      BH4; BH4 Bcl-2 homology region 4
      cd06845
      Location:81194
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
      TIGR00865
      Location:1233
      bcl-2; apoptosis regulator

    RNA

    1. NR_134257.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1 renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AI872556, BC019307, CD359906

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p7 Primary Assembly

      Range
      31664452..31723999 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011528964.2XP_011527266.1  bcl-2-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011527266.1

      UniProtKB/Swiss-Prot
      Q07817
      UniProtKB/TrEMBL
      A0A0S2Z3C5
      Conserved Domains (3) summary
      smart00265
      Location:127
      BH4; BH4 Bcl-2 homology region 4
      cd06845
      Location:81194
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
      TIGR00865
      Location:1233
      bcl-2; apoptosis regulator
    2. XM_017027993.1XP_016883482.1  bcl-2-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q07817
      UniProtKB/TrEMBL
      A0A0S2Z3C5
      Conserved Domains (3) summary
      smart00265
      Location:127
      BH4; BH4 Bcl-2 homology region 4
      cd06845
      Location:81194
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
      TIGR00865
      Location:1233
      bcl-2; apoptosis regulator

    RNA

    1. XR_001754364.1 RNA Sequence

    2. XR_936599.2 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018931.2 Alternate CHM1_1.1

      Range
      30156165..30215683 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center