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    alkB oxidative demethylase of N1-methyladenine or N3-methylcytosine DNA lesions [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946708, updated on 25-May-2017
    Gene symbol
    alkB
    Gene description
    oxidative demethylase of N1-methyladenine or N3-methylcytosine DNA lesions
    Primary source
    EcoGene:EG10037
    Locus tag
    b2212
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia
    Also known as
    aidD; ECK2204; JW2200
    Summary
    AlkB mutants are extremely sensitive to MMS. [More information is available at EcoGene: EG10037]. AlkB is a Fe(II)-containing, 2-oxoglutarate-dependent dioxygenase involved in the adaptive DNA-repair response of Escherichia coli to alkylating agents. [More information is available at EcoCyc: EG10037].
    Sequence:
    NC_000913.3 (2308691..2309341, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene malate dehydrogenase, FAD/NAD(P)-binding domain Neighboring gene microcin J25 efflux ABC transporter permease/ATPase Neighboring gene fused DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase Neighboring gene putative thiamine-synthetic flavin transferase lipoprotein

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    1-ethyladenine demethylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-N1-methyladenine dioxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosine C-5 DNA demethylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dioxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ferrous iron binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    methylcytosine dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    oxidative RNA demethylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA dealkylation involved in DNA repair IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA demethylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    RNA repair IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidative demethylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidative single-stranded DNA demethylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidative single-stranded RNA demethylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Names
    oxidative demethylase of N1-methyladenine or N3-methylcytosine DNA lesions
    NP_416716.1
    • DNA repair system specific for alkylated DNA

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2308691..2309341 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416716.1 oxidative demethylase of N1-methyladenine or N3-methylcytosine DNA lesions [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416716.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P05050
      Conserved Domains (1) summary
      PRK15401
      Location:1212
      PRK15401; alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional
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