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    Insr insulin receptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24954, updated on 12-Jun-2017
    Official Symbol
    Insrprovided by RGD
    Official Full Name
    insulin receptorprovided by RGD
    Primary source
    RGD:2917
    See related
    Ensembl:ENSRNOG00000029986 Vega:OTTRNOG00000001719
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    receptor for insulin; involved in intracellular signalling; mutations in gene are associated with type 2 diabetes mellitus [RGD, Feb 2006]
    Orthologs
    Location:
    12p12
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (1682527..1816414, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 12 NC_005111.3 (3848670..3989302, complement)

    Chromosome 12 - NC_005111.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103693612 Neighboring gene uncharacterized LOC102554571 Neighboring gene 5S RNA Neighboring gene Rho/Rac guanine nucleotide exchange factor 18 Neighboring gene peroxisomal biogenesis factor 11 gamma

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    3-phosphoinositide-dependent protein kinase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    PTB domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    PTB domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    insulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    insulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    insulin binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    insulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    insulin receptor substrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    insulin receptor substrate binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    insulin receptor substrate binding ISO
    Inferred from Sequence Orthology
    more info
     
    insulin-activated receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    insulin-activated receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    insulin-activated receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    insulin-activated receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    insulin-like growth factor I binding IEA
    Inferred from Electronic Annotation
    more info
     
    insulin-like growth factor I binding ISO
    Inferred from Sequence Orthology
    more info
     
    insulin-like growth factor II binding IEA
    Inferred from Electronic Annotation
    more info
     
    insulin-like growth factor II binding ISO
    Inferred from Sequence Orthology
    more info
     
    insulin-like growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    insulin-like growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    lipoic acid binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    phosphatidylinositol 3-kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol 3-kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein phosphatase binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    signal transducer, downstream of receptor, with protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    signal transducer, downstream of receptor, with protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    activation of MAPK activity IEA
    Inferred from Electronic Annotation
    more info
     
    activation of MAPK activity ISO
    Inferred from Sequence Orthology
    more info
     
    activation of protein kinase B activity IEA
    Inferred from Electronic Annotation
    more info
     
    activation of protein kinase B activity ISO
    Inferred from Sequence Orthology
    more info
     
    activation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    adrenal gland development IEA
    Inferred from Electronic Annotation
    more info
     
    adrenal gland development ISO
    Inferred from Sequence Orthology
    more info
     
    animal organ morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cerebellum development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    epidermis development IEA
    Inferred from Electronic Annotation
    more info
     
    epidermis development ISO
    Inferred from Sequence Orthology
    more info
     
    exocrine pancreas development IEA
    Inferred from Electronic Annotation
    more info
     
    exocrine pancreas development ISO
    Inferred from Sequence Orthology
    more info
     
    fat cell differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    glucose homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    heart morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    heart morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    hippocampus development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    male gonad development IEA
    Inferred from Electronic Annotation
    more info
     
    male gonad development ISO
    Inferred from Sequence Orthology
    more info
     
    male sex determination IEA
    Inferred from Electronic Annotation
    more info
     
    male sex determination ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-tyrosine autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-tyrosine autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of developmental growth IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of developmental growth ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glucose import IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glycogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of glycogen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glycolytic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of glycolytic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glycoprotein biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of meiotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitotic nuclear division IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of nitric oxide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein kinase B signaling IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of respiratory burst IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of respiratory burst ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein autophosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein heterotetramerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein heterotetramerization IEA
    Inferred from Electronic Annotation
    more info
     
    protein heterotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of female gonad development IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of female gonad development ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of hydrogen peroxide metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    response to activity IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to estradiol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to glucocorticoid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to glucose IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to insulin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to manganese ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to nutrient levels IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to testosterone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to tumor necrosis factor IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to vitamin D IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    signal transduction by protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    transformation of host cell by virus IEA
    Inferred from Electronic Annotation
    more info
     
    transformation of host cell by virus ISO
    Inferred from Sequence Orthology
    more info
     
    transmembrane receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    caveola IEA
    Inferred from Electronic Annotation
    more info
     
    caveola ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    insulin receptor complex IEA
    Inferred from Electronic Annotation
    more info
     
    insulin receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    insulin receptor
    Names
    IR
    insulin receptor preproprotein
    NP_058767.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017071.2NP_058767.2  insulin receptor preproprotein

      See identical proteins and their annotated locations for NP_058767.2

      Status: VALIDATED

      Source sequence(s)
      AABR07034944, AABR07034945, AABR07034946
      UniProtKB/TrEMBL
      T2CB11
      Related
      ENSRNOP00000049655.4, OTTRNOP00000001630, ENSRNOT00000041155.3, OTTRNOT00000002765
      Conserved Domains (6) summary
      cd05061
      Location:10181305
      PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
      cd00063
      Location:869946
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00064
      Location:234281
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam00757
      Location:179337
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:359472
      Recep_L_domain; Receptor L domain
      pfam07714
      Location:10251292
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005111.4 Reference Rnor_6.0 Primary Assembly

      Range
      1682527..1816414 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000080.1 Alternate Rn_Celera

      Range
      3053590..3185991 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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