Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    CSF3 colony stimulating factor 3 [ Homo sapiens (human) ]

    Gene ID: 1440, updated on 22-Sep-2016
    Official Symbol
    CSF3provided by HGNC
    Official Full Name
    colony stimulating factor 3provided by HGNC
    Primary source
    HGNC:HGNC:2438
    See related
    Ensembl:ENSG00000108342 HPRD:00736; MIM:138970; Vega:OTTHUMG00000133247
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GCSF; CSF3OS; C17orf33
    Summary
    The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes. The active protein is found extracellularly. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]
    Orthologs
    Location:
    17q11.2-q12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 17 NC_000017.11 (40015361..40017813)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (38171614..38174066)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene gasdermin A Neighboring gene proteasome 26S subunit, non-ATPase 3 Neighboring gene mediator complex subunit 24 Neighboring gene microRNA 6884 Neighboring gene small nucleolar RNA, C/D box 124

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Common variations in PSMD3-CSF3 and PLCB4 are associated with neutrophil count.
    NHGRI GWA Catalog
    Genome-wide association study of hematological and biochemical traits in a Japanese population.
    NHGRI GWA Catalog
    Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.
    NHGRI GWA Catalog
    Multiple loci are associated with white blood cell phenotypes.
    NHGRI GWA Catalog
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokines and Inflammatory Response, organism-specific biosystem (from WikiPathways)
      Cytokines and Inflammatory Response, organism-specific biosystemInflammation is a protective response to infection by the immune system that requires communication between different classes of immune cells to coordinate their actions. Acute inflammation is an imp...
    • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
      Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hematopoietic cell lineage, conserved biosystem (from KEGG)
      Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
      Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
      Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Malaria, organism-specific biosystem (from KEGG)
      Malaria, organism-specific biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
    • Malaria, conserved biosystem (from KEGG)
      Malaria, conserved biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC45931

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cytokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytokine activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    granulocyte colony-stimulating factor receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    cellular response to cytokine stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    cytokine-mediated signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    granulocyte differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    immune response IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism development TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of neuron death IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of actin cytoskeleton reorganization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of actin filament polymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of myeloid cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of phosphatidylinositol 3-kinase signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein kinase B signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription factor import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    granulocyte colony-stimulating factor
    Names
    colony stimulating factor 3 (granulocyte)
    filgrastim
    granulocyte-colony stimulating factor
    lenograstim
    pluripoietin

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000759.3NP_000750.1  granulocyte colony-stimulating factor isoform a precursor

      See identical proteins and their annotated locations for NP_000750.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      BC033245, CB127794, X03438
      Consensus CDS
      CCDS11357.1
      UniProtKB/Swiss-Prot
      P09919
      UniProtKB/TrEMBL
      Q8N4W3
      Related
      ENSP00000225474, OTTHUMP00000164325, ENST00000225474, OTTHUMT00000256988
      Conserved Domains (1) summary
      pfam16647
      Location:51202
      GCSF; Granulocyte colony-stimulating factor
    2. NM_001178147.1NP_001171618.1  granulocyte colony-stimulating factor isoform d precursor

      See identical proteins and their annotated locations for NP_001171618.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate, in-frame splice site and lacks an in-frame exon in the middle portion of the coding region, compared to variant 1. This results in a shorter protein (isoform d), compared to isoform a.
      Source sequence(s)
      BC033245, CB127794, X03438
      UniProtKB/Swiss-Prot
      P09919
      UniProtKB/TrEMBL
      Q8N4W3
      Related
      ENSP00000464421, OTTHUMP00000261717, ENST00000583218, OTTHUMT00000446854
      Conserved Domains (1) summary
      cl02473
      Location:51163
      IL6; Interleukin-6/G-CSF/MGF family
    3. NM_172219.2NP_757373.1  granulocyte colony-stimulating factor isoform b precursor

      See identical proteins and their annotated locations for NP_757373.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1, resulting in a shorter isoform (b).
      Source sequence(s)
      AK313509, BC033245, CB127794, X03655
      Consensus CDS
      CCDS42314.1
      UniProtKB/Swiss-Prot
      P09919
      UniProtKB/TrEMBL
      Q6FH65, Q8N4W3
      Related
      ENSP00000377705, OTTHUMP00000164327, ENST00000394149, OTTHUMT00000256990
      Conserved Domains (1) summary
      pfam16647
      Location:51199
      GCSF; Granulocyte colony-stimulating factor
    4. NM_172220.2NP_757374.2  granulocyte colony-stimulating factor isoform c precursor

      See identical proteins and their annotated locations for NP_757374.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the middle portion of the coding region, compared to variant 1. This results in a shorter protein (isoform c), compared to isoform a.
      Source sequence(s)
      BC033245, CB127794, CD013926, X03655
      Consensus CDS
      CCDS11358.2
      UniProtKB/Swiss-Prot
      P09919
      UniProtKB/TrEMBL
      Q8N4W3
      Related
      ENSP00000377704, OTTHUMP00000164328, ENST00000394148, OTTHUMT00000256991
      Conserved Domains (1) summary
      cl02473
      Location:51166
      IL6; Interleukin-6/G-CSF/MGF family

    RNA

    1. NR_033662.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains an alternate segment and uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC033245, CB127794, X03438
      Related
      ENST00000331769, OTTHUMT00000256989

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p7 Primary Assembly

      Range
      40015361..40017813
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      38407306..38409759
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center