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    Sirpa signal-regulatory protein alpha [ Mus musculus (house mouse) ]

    Gene ID: 19261, updated on 8-Oct-2017
    Official Symbol
    Sirpaprovided by MGI
    Official Full Name
    signal-regulatory protein alphaprovided by MGI
    Primary source
    MGI:MGI:108563
    See related
    Ensembl:ENSMUSG00000037902 Vega:OTTMUSG00000015506
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bit; P84; SIRP; SHP-1; CD172a; Ptpns1; SHPS-1; AI835480
    Orthologs
    Location:
    2 F1; 2 63.19 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (129592665..129632228)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (129418575..129457964)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA F830045P16 gene Neighboring gene predicted gene 14040 Neighboring gene predicted gene 14041 Neighboring gene prodynorphin Neighboring gene peptidylprolyl isomerase A (Ppia) pseudogene 2_1620.1

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein phosphorylated amino acid binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    movement of cell or subcellular component IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phagocytosis, engulfment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phagocytosis, recognition IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of phagocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    tyrosine-protein phosphatase non-receptor type substrate 1
    Names
    CD172 antigen-like family member A
    SHP substrate 1
    brain Ig-like molecule with tyrosine-based activation motifs
    brain immunological-like with tyrosine-based motifs
    inhibitory receptor SHPS-1
    mSIRP-alpha1
    myD-1 antigen
    protein tyrosine phosphatase, non-receptor type substrate 1
    signal-regulatory protein alpha-1
    sirp-alpha-1
    NP_001171118.1
    NP_001277948.1
    NP_001277949.1
    NP_001277950.1
    NP_001277951.1
    NP_031573.2
    XP_006499049.1
    XP_017172050.1
    XP_017172053.1
    XP_017172057.1
    XP_017172058.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177647.2NP_001171118.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001171118.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons in the central coding region, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 4. The encoded isoform (2) is shorter than isoform 3.
      Source sequence(s)
      AF072544, AK159617, BM899883, CD578948
      Consensus CDS
      CCDS50708.1
      UniProtKB/Swiss-Prot
      P97797
      UniProtKB/TrEMBL
      A0A0R4J1Z7
      Related
      ENSMUSP00000125004.1, OTTMUSP00000047031, ENSMUST00000160276.1, OTTMUST00000086794
      Conserved Domains (2) summary
      smart00410
      Location:41145
      IG_like; Immunoglobulin like
      pfam07686
      Location:38146
      V-set; Immunoglobulin V-set domain
    2. NM_001291019.1NP_001277948.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001277948.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (3). Both variants 4 and 5 encode isoform 3.
      Source sequence(s)
      AB018194, AK159617, BM899883, CD578948
      Consensus CDS
      CCDS71142.1
      UniProtKB/Swiss-Prot
      P97797
      UniProtKB/TrEMBL
      E0CYM8
      Related
      ENSMUSP00000049022.7, OTTMUSP00000047033, ENSMUST00000049262.13, OTTMUST00000086796
      Conserved Domains (4) summary
      cd00098
      Location:257336
      IgC; Immunoglobulin Constant domain
      smart00410
      Location:41145
      IG_like; Immunoglobulin like
      pfam07686
      Location:38146
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:145255
      Ig; Immunoglobulin domain
    3. NM_001291020.1NP_001277949.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001277949.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 4. Both variants 4 and 5 encode isoform 3.
      Source sequence(s)
      AB018194, AK159617, BM899883
      Consensus CDS
      CCDS71142.1
      UniProtKB/Swiss-Prot
      P97797
      UniProtKB/TrEMBL
      E0CYM8
      Related
      ENSMUSP00000124048.1, OTTMUSP00000047032, ENSMUST00000161620.7, OTTMUST00000086795
      Conserved Domains (4) summary
      cd00098
      Location:257336
      IgC; Immunoglobulin Constant domain
      smart00410
      Location:41145
      IG_like; Immunoglobulin like
      pfam07686
      Location:38146
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:145255
      Ig; Immunoglobulin domain
    4. NM_001291021.1NP_001277950.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 4 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks two alternate in-frame exons in the central coding region, compared to variant 4, resulting in an isoform (4) that is shorter than isoform 3.
      Source sequence(s)
      AK159617, BM899883, CD578948, CX236057
      Consensus CDS
      CCDS71143.1
      UniProtKB/TrEMBL
      E9QPT7
      Related
      ENSMUSP00000096713.3, ENSMUST00000099113.9
      Conserved Domains (2) summary
      smart00410
      Location:41145
      IG_like; Immunoglobulin like
      pfam07686
      Location:38146
      V-set; Immunoglobulin V-set domain
    5. NM_001291022.1NP_001277951.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 5 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks an alternate in-frame exon in the 5' coding region and two in-frame exons in the central coding region, and also uses an alternate in-frame splice site in the 3' coding region, compared to variant 4. The encoded isoform (5) is shorter than isoform 3.
      Source sequence(s)
      AK159617, BM899883, CD578948, CJ151068
      Consensus CDS
      CCDS79845.1
      UniProtKB/TrEMBL
      E0CX65
      Related
      ENSMUSP00000124888.1, OTTMUSP00000047034, ENSMUST00000163034.7, OTTMUST00000086797
    6. NM_001355158.1NP_001342087.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variant 1, encodes isoform 1.
      Source sequence(s)
      AL808126
      Conserved Domains (3) summary
      cd05772
      Location:148251
      IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2
      cd16085
      Location:253356
      IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3
      cl11960
      Location:35146
      Ig; Immunoglobulin domain
    7. NM_001355160.1NP_001342089.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL808126
      Conserved Domains (3) summary
      cd05772
      Location:136239
      IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2
      cd16085
      Location:241344
      IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3
      cl11960
      Location:23134
      Ig; Immunoglobulin domain
    8. NM_007547.4NP_031573.2  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_031573.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 3' coding region, compared to variant 4, resulting in an isoform (1) that is shorter than isoform 3. Variants 1 and 8 both encode the same isoform (1).
      Source sequence(s)
      AF072543, AK159617, BM899883, CD578948
      Consensus CDS
      CCDS16729.1
      UniProtKB/Swiss-Prot
      P97797
      UniProtKB/TrEMBL
      Q6P6I8
      Related
      ENSMUSP00000099491.3, OTTMUSP00000016522, ENSMUST00000103202.9, OTTMUST00000036826
      Conserved Domains (3) summary
      cd05772
      Location:148251
      IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2
      cd16085
      Location:253356
      IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3
      cl11960
      Location:35146
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      129592665..129632228
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316568.1XP_017172057.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X4

      UniProtKB/TrEMBL
      E9QPT7
      Conserved Domains (2) summary
      smart00410
      Location:41145
      IG_like; Immunoglobulin like
      pfam07686
      Location:38146
      V-set; Immunoglobulin V-set domain
    2. XM_017316564.1XP_017172053.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X3

      Conserved Domains (4) summary
      cd00098
      Location:250329
      IgC; Immunoglobulin Constant domain
      smart00410
      Location:34138
      IG_like; Immunoglobulin like
      pfam07686
      Location:31139
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:138248
      Ig; Immunoglobulin domain
    3. XM_017316561.1XP_017172050.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X2

      UniProtKB/Swiss-Prot
      P97797
      UniProtKB/TrEMBL
      Q6P6I8
      Related
      ENSMUSP00000137611.1, ENSMUST00000179001.7
      Conserved Domains (3) summary
      cd05772
      Location:148251
      IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2
      cd16085
      Location:253356
      IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3
      cl11960
      Location:35146
      Ig; Immunoglobulin domain
    4. XM_017316569.1XP_017172058.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X5

      UniProtKB/Swiss-Prot
      P97797
      UniProtKB/TrEMBL
      A0A0R4J1Z7
      Conserved Domains (2) summary
      smart00410
      Location:41145
      IG_like; Immunoglobulin like
      pfam07686
      Location:38146
      V-set; Immunoglobulin V-set domain
    5. XM_006498986.3XP_006499049.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X1

      See identical proteins and their annotated locations for XP_006499049.1

      UniProtKB/TrEMBL
      E0CYM8
      Conserved Domains (4) summary
      cd00098
      Location:257336
      IgC; Immunoglobulin Constant domain
      smart00410
      Location:41145
      IG_like; Immunoglobulin like
      pfam07686
      Location:38146
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:145255
      Ig; Immunoglobulin domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001177646.1: Suppressed sequence

      Description
      NM_001177646.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    Support Center