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    AXIN1 axin 1 [ Homo sapiens (human) ]

    Gene ID: 8312, updated on 18-Dec-2016
    Official Symbol
    AXIN1provided by HGNC
    Official Full Name
    axin 1provided by HGNC
    Primary source
    HGNC:HGNC:903
    See related
    Ensembl:ENSG00000103126 MIM:603816; Vega:OTTHUMG00000064930
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AXIN; PPP1R49
    Summary
    This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
    Orthologs
    Location:
    16p13.3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 16 NC_000016.10 (287440..355226, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (337440..405244, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene Rho GDP dissociation inhibitor gamma Neighboring gene protein disulfide isomerase family A member 2 Neighboring gene mitochondrial ribosomal protein L28 Neighboring gene transmembrane protein 8A

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Caudal duplication anomaly
    MedGen: C1842884 OMIM: 607864 GeneReviews: Not available
    Compare labs
    Hepatocellular carcinoma
    MedGen: C2239176 OMIM: 114550 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
    NHGRI GWA Catalog

    Replication interactions

    Interaction Pubs
    Knockdown of axin1 by siRNAs significantly enhances HIV-1 replication in human acute monocytic leukemia cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Axin1 regulates HIV-1 Tat-mediated transcription, which requires beta-catenin and TCF4 PubMed

    Go to the HIV-1, Human Interaction Database

    • AMER1 mutants destabilize the destruction complex, organism-specific biosystem (from REACTOME)
      AMER1 mutants destabilize the destruction complex, organism-specific biosystemAMER1/WTX is a component of the destruction complex that interacts directly with beta-catenin through its C-terminal half. Depletion of AMER1 through siRNA stabilizes cellular beta-catenin levels an...
    • APC truncation mutants have impaired AXIN binding, organism-specific biosystem (from REACTOME)
      APC truncation mutants have impaired AXIN binding, organism-specific biosystemMutations in the APC tumor suppressor gene are common in colorectal and other cancers and cluster in the central mutation cluster region (MCR) of the gene (Miyoshi et al, 1992; Nagase and Nakamura, ...
    • AXIN missense mutants destabilize the destruction complex, organism-specific biosystem (from REACTOME)
      AXIN missense mutants destabilize the destruction complex, organism-specific biosystemAlterations in AXIN1 have been detected in a number of different cancers including liver and colorectal cancer and medullablastoma, among others (reviewed in Salahshor and Woodgett, 2005). Missense ...
    • AXIN mutants destabilize the destruction complex, activating WNT signaling, organism-specific biosystem (from REACTOME)
      AXIN mutants destabilize the destruction complex, activating WNT signaling, organism-specific biosystemAXIN1 and AXIN2 are critical scaffolding proteins of the beta-catenin destruction complex and make protein-protein interactions with several of the other complex components including APC, GSK3, CK1 a...
    • Apoptosis-related network due to altered Notch3 in ovarian cancer, organism-specific biosystem (from WikiPathways)
      Apoptosis-related network due to altered Notch3 in ovarian cancer, organism-specific biosystemResults of pathway analysis of apoptosis-related genes in OVCAR3 cells treated with Notch3 siRNA or control siRNA.
    • Association Between Physico-Chemical Features and Toxicity Associated Pathways, organism-specific biosystem (from WikiPathways)
      Association Between Physico-Chemical Features and Toxicity Associated Pathways, organism-specific biosystemThis pathway is based on Figure 8 of "Mapping drug physico-chemical features to pathway activity reveals molecular networks linked to toxicity outcome."(See bibliography). These 3 pathways demonstr...
    • Basal cell carcinoma, organism-specific biosystem (from KEGG)
      Basal cell carcinoma, organism-specific biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
    • Basal cell carcinoma, conserved biosystem (from KEGG)
      Basal cell carcinoma, conserved biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
    • Beta-catenin phosphorylation cascade, organism-specific biosystem (from REACTOME)
      Beta-catenin phosphorylation cascade, organism-specific biosystemDegradation of beta-catenin is initiated following amino-terminal serine/threonine phosphorylation. Phosphorylation of B-catenin at S45 by CK1 alpha primes the subsequent sequential GSK-3-mediated p...
    • Breast cancer, organism-specific biosystem (from KEGG)
      Breast cancer, organism-specific biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
    • Breast cancer, conserved biosystem (from KEGG)
      Breast cancer, conserved biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
    • C-MYC pathway, organism-specific biosystem (from Pathway Interaction Database)
      C-MYC pathway, organism-specific biosystem
      C-MYC pathway
    • Canonical Wnt signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      Canonical Wnt signaling pathway, organism-specific biosystem
      Canonical Wnt signaling pathway
    • Colorectal cancer, organism-specific biosystem (from KEGG)
      Colorectal cancer, organism-specific biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
    • Colorectal cancer, conserved biosystem (from KEGG)
      Colorectal cancer, conserved biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
    • DNA Damage Response (only ATM dependent), organism-specific biosystem (from WikiPathways)
      DNA Damage Response (only ATM dependent), organism-specific biosystemThis is the second pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and TP53) which are connected with the first DNA damage response pathway. In...
    • Degradation of AXIN, organism-specific biosystem (from REACTOME)
      Degradation of AXIN, organism-specific biosystemAXIN is present in low concentrations in the cell and is considered to be the limiting component of the beta-catenin destruction complex in Xenopus; this may not be the case in mammalian cells, howev...
    • Degradation of beta-catenin by the destruction complex, organism-specific biosystem (from REACTOME)
      Degradation of beta-catenin by the destruction complex, organism-specific biosystemThe beta-catenin destruction complex plays a key role in the canonical Wnt signaling pathway. In the absence of Wnt signaling, this complex controls the levels of cytoplamic beta-catenin. Beta-cateni...
    • Deubiquitination, organism-specific biosystem (from REACTOME)
      Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
    • Disassembly of the destruction complex and recruitment of AXIN to the membrane, organism-specific biosystem (from REACTOME)
      Disassembly of the destruction complex and recruitment of AXIN to the membrane, organism-specific biosystemUpon stimulation with WNT ligand, AXIN and GSK3beta are recruited to the plasma membrane through interaction with DVL (Tamai et al, 2004; Mao et al, 2001; reviewed in He et al, 2004). Polymerization...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Diseases of signal transduction, organism-specific biosystem (from REACTOME)
      Diseases of signal transduction, organism-specific biosystemSignaling processes are central to human physiology (e.g., Pires-da Silva & Sommer 2003), and their disruption by either germ-line and somatic mutation can lead to serious disease. Here, the molecula...
    • Endometrial cancer, organism-specific biosystem (from KEGG)
      Endometrial cancer, organism-specific biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
    • Endometrial cancer, conserved biosystem (from KEGG)
      Endometrial cancer, conserved biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
    • Extracellular vesicle-mediated signaling in recipient cells, organism-specific biosystem (from WikiPathways)
      Extracellular vesicle-mediated signaling in recipient cells, organism-specific biosystemProtein sorting during formation of multivesicular bodies results in packaging of key molecules in exosomes. Exosomes bound-signaling ligands once released from host cells interacts with the receptor...
    • Hippo signaling pathway, organism-specific biosystem (from KEGG)
      Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
    • Hippo signaling pathway, conserved biosystem (from KEGG)
      Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
    • Mesodermal Commitment Pathway, organism-specific biosystem (from WikiPathways)
      Mesodermal Commitment Pathway, organism-specific biosystemModel depicting mesodermal specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell l...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Misspliced GSK3beta mutants stabilize beta-catenin, organism-specific biosystem (from REACTOME)
      Misspliced GSK3beta mutants stabilize beta-catenin, organism-specific biosystemGSK3beta is subject to in-frame missplicing in CML stem cells resulting in the production of mutant protein that lacks the AXIN and FRAT binding domains. Cells containing this mutant GSK3beta show e...
    • N-cadherin signaling events, organism-specific biosystem (from Pathway Interaction Database)
      N-cadherin signaling events, organism-specific biosystem
      N-cadherin signaling events
    • Neural Crest Differentiation, organism-specific biosystem (from WikiPathways)
      Neural Crest Differentiation, organism-specific biosystemGene regulatory network model of cranial neural crest cell (CNCC) development, adaped from PMID: 19575671. Most interactions in the model are proposed to regulate transcription of core factors involv...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • Presenilin action in Notch and Wnt signaling, organism-specific biosystem (from Pathway Interaction Database)
      Presenilin action in Notch and Wnt signaling, organism-specific biosystem
      Presenilin action in Notch and Wnt signaling
    • Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds, organism-specific biosystem (from WikiPathways)
      Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds, organism-specific biosystemThe Wnt/B-catenin pathway begins with Wnt family activation by MBOAT that allows Wnt proteins to translocate out of a cell and bind to FZD and LRP to form a complex. This complex stimulates B-catenin...
    • S33 mutants of beta-catenin aren't phosphorylated, organism-specific biosystem (from REACTOME)
      S33 mutants of beta-catenin aren't phosphorylated, organism-specific biosystemS33 mutations of beta-catenin interfere with GSK3 phosphorylation and result in stabilization and nuclear localization of the protein and enhanced WNT signaling (Groen et al, 2008; Nhieu et al, 1999;...
    • S37 mutants of beta-catenin aren't phosphorylated, organism-specific biosystem (from REACTOME)
      S37 mutants of beta-catenin aren't phosphorylated, organism-specific biosystemS37 mutations of beta-catenin interfere with GSK3 phosphorylation and stabilize the protein, resulting in enhanced WNT pathway signaling (Nhieu et al, 1999; Clements et al, 2002; reviewed in Polakis,...
    • S45 mutants of beta-catenin aren't phosphorylated, organism-specific biosystem (from REACTOME)
      S45 mutants of beta-catenin aren't phosphorylated, organism-specific biosystemS45 mutants of beta-catenin have been identified in colorectal and hepatocellular carcinomas, soft tissue cancer and Wilms Tumors, among others (reviewed in Polakis, 2000). These mutations abolish th...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by WNT in cancer, organism-specific biosystem (from REACTOME)
      Signaling by WNT in cancer, organism-specific biosystemThe WNT signaling pathway has been linked with cancer ever since the identification of the first WNT as a gene activated by integration of mouse mammary tumor virus proviral DNA in virally-induced br...
    • Signaling by Wnt, organism-specific biosystem (from REACTOME)
      Signaling by Wnt, organism-specific biosystemWNT signaling pathways control a wide range of developmental and adult process in metozoans including cell proliferation, cell fate decisions, cell polarity and stem cell maintenance (reviewed in Sai...
    • Signaling pathways regulating pluripotency of stem cells, organism-specific biosystem (from KEGG)
      Signaling pathways regulating pluripotency of stem cells, organism-specific biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
    • Signaling pathways regulating pluripotency of stem cells, conserved biosystem (from KEGG)
      Signaling pathways regulating pluripotency of stem cells, conserved biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
    • T41 mutants of beta-catenin aren't phosphorylated, organism-specific biosystem (from REACTOME)
      T41 mutants of beta-catenin aren't phosphorylated, organism-specific biosystemT41 mutations of beta-catenin interfere with GSK3 phosphorylation and result in stabilization and nuclear accumulation of the protein (Moreno-Bueno et al, 2002; Taniguchi et al, 2002; reviewed in Pol...
    • TCF dependent signaling in response to WNT, organism-specific biosystem (from REACTOME)
      TCF dependent signaling in response to WNT, organism-specific biosystem19 WNT ligands and 10 FZD receptors have been identified in human cells; interactions amongst these ligands and receptors vary in a developmental and tissue-specific manner and lead to activation of ...
    • TGF-beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Signaling Pathway, organism-specific biosystemThe signal transduction mechanisms underlying the pathophysiological activities of transforming growth factor-? (TGF-?) have been extensively studied since its discovery nearly 30 years ago. TGF-? li...
    • TGF-beta receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
      TGF-beta receptor signaling, organism-specific biosystem
      TGF-beta receptor signaling
    • Truncations of AMER1 destabilize the destruction complex, organism-specific biosystem (from REACTOME)
      Truncations of AMER1 destabilize the destruction complex, organism-specific biosystemAMER1/WTX is a known component of the destruction complex and interacts directly with beta-catenin through the C-terminal half (Major et al, 2007). siRNA depletion of AMER1 in mammalian cells stabil...
    • Ub-specific processing proteases, organism-specific biosystem (from REACTOME)
      Ub-specific processing proteases, organism-specific biosystemUb-specific processing proteases (USPs) are the largest of the DUB families with more than 50 members in humans. The USP catalytic domain varies considerably in size and consists of six conserved mo...
    • Wnt Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt Signaling Pathway Netpath, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway Netpath, organism-specific biosystemWNT signal, through the canonical pathway, controls cell fate determination and through the non-canonical pathway controls cell movement and tissue polarity. The name "wnt" is a fusion of two terms, ...
    • Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell plurip...
    • Wnt signaling pathway, organism-specific biosystem (from KEGG)
      Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt signaling pathway, conserved biosystem (from KEGG)
      Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex, organism-specific biosystem (from REACTOME)
      phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex, organism-specific biosystemMutations in exon 3 of the beta-catenin gene have been identified in a number of human cancers (Morin et al, 1997; Rubinfeld et al, 1997; reviewed in Polakis, 2000; Polakis, 2007). These mutations g...
    • truncated APC mutants destabilize the destruction complex, organism-specific biosystem (from REACTOME)
      truncated APC mutants destabilize the destruction complex, organism-specific biosystemAPC is a large and central component of the destruction complex, which limits signaling in the absence of WNT ligand by promoting the ubiquitin-mediated degradation of beta-catenin. APC interacts wi...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC52315

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    I-SMAD binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    SMAD binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    armadillo repeat domain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    armadillo repeat domain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    beta-catenin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex scaffold IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex scaffold IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    receptor signaling complex scaffold activity IEA
    Inferred from Electronic Annotation
    more info
     
    signal transducer activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    Wnt signaling pathway TAS
    Traceable Author Statement
    more info
     
    Wnt signaling pathway involved in somitogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Wnt-activated signaling pathway involved in forebrain neuron fate commitment IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    activation of JUN kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    activation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    axial mesoderm formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    beta-catenin destruction complex assembly TAS
    Traceable Author Statement
    more info
     
    beta-catenin destruction complex disassembly TAS
    Traceable Author Statement
    more info
     
    canonical Wnt signaling pathway IC
    Inferred by Curator
    more info
    PubMed 
    canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cell death IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cellular protein complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to organic cyclic compound IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    determination of left/right symmetry IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    dorsal/ventral axis specification IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    embryonic eye morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    embryonic skeletal joint morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    forebrain anterior/posterior pattern specification IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    muscle cell development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of fat cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of transcription elongation from RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    olfactory placode formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    optic placode formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of JNK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of canonical Wnt signaling pathway TAS
    Traceable Author Statement
    more info
     
    positive regulation of peptidyl-serine phosphorylation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of peptidyl-threonine phosphorylation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of protein catabolic process IC
    Inferred by Curator
    more info
    PubMed 
    positive regulation of protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein ubiquitination NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ubiquitin-protein transferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    proteasome-mediated ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
     
    regulation of catenin import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    beta-catenin destruction complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cell periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytoplasmic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    axin-1
    Names
    axis inhibition protein 1
    axis inhibitor 1
    fused, mouse, homolog of
    protein phosphatase 1, regulatory subunit 49

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012267.1 RefSeqGene

      Range
      4789..70025
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003502.3NP_003493.1  axin-1 isoform a

      See identical proteins and their annotated locations for NP_003493.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform (a). An upstream in-frame AUG is present that could extend the N-terminus of this isoform by 49 aa; however, there is no evidence that the upstream AUG is used, so the shorter N-terminus is being annotated.
      Source sequence(s)
      AC005202, AF009674, BC035872, DB460285, Z69667, Z99754
      Consensus CDS
      CCDS10405.1
      UniProtKB/Swiss-Prot
      O15169
      UniProtKB/TrEMBL
      A0A0S2Z4R0
      Related
      ENSP00000262320, OTTHUMP00000067405, ENST00000262320, OTTHUMT00000139441
      Conserved Domains (4) summary
      cd08707
      Location:89209
      RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
      cd11582
      Location:1180
      Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin
      pfam00778
      Location:782857
      DIX; DIX domain
      pfam08833
      Location:464520
      Axin_b-cat_bind; Axin beta-catenin binding domain
    2. NM_181050.2NP_851393.1  axin-1 isoform b

      See identical proteins and their annotated locations for NP_851393.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. The resulting protein (isoform b) is shorter, compared to isoform a. An upstream in-frame AUG is present that could extend the N-terminus of this isoform by 49 aa; however, there is no evidence that the upstream AUG is used, so the shorter N-terminus is being annotated.
      Source sequence(s)
      AC005202, BC035872, BC044648, DB460285, Z69667
      Consensus CDS
      CCDS10406.1
      UniProtKB/Swiss-Prot
      O15169
      UniProtKB/TrEMBL
      A0A0S2Z4S3
      Related
      ENSP00000346935, OTTHUMP00000067406, ENST00000354866, OTTHUMT00000139442
      Conserved Domains (4) summary
      cd08707
      Location:89209
      RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
      cd11582
      Location:1180
      Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin
      pfam00778
      Location:746821
      DIX; DIX domain
      pfam08833
      Location:464520
      Axin_b-cat_bind; Axin beta-catenin binding domain

    RNA

    1. NR_134879.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC035872, KF615852

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p7 Primary Assembly

      Range
      287440..355226 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011522684.2XP_011520986.1  

      Conserved Domains (4) summary
      cd08707
      Location:89209
      RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
      cd11582
      Location:1180
      Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin
      pfam00778
      Location:787862
      DIX; DIX domain
      pfam08833
      Location:469525
      Axin_b-cat_bind; Axin beta-catenin binding domain
    2. XM_017023743.1XP_016879232.1  

    3. XM_011522682.2XP_011520984.1  

      Conserved Domains (4) summary
      cd08707
      Location:138258
      RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
      cd11582
      Location:60129
      Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin
      pfam00778
      Location:836911
      DIX; DIX domain
      pfam08833
      Location:518574
      Axin_b-cat_bind; Axin beta-catenin binding domain
    4. XM_017023744.1XP_016879233.1  

    5. XM_011522683.2XP_011520985.1  

      Conserved Domains (4) summary
      cd08707
      Location:138258
      RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
      cd11582
      Location:60129
      Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin
      pfam00778
      Location:800875
      DIX; DIX domain
      pfam08833
      Location:518574
      Axin_b-cat_bind; Axin beta-catenin binding domain
    6. XM_017023745.1XP_016879234.1  

    7. XM_011522686.1XP_011520988.1  

      Conserved Domains (2) summary
      pfam00778
      Location:501576
      DIX; DIX domain
      pfam08833
      Location:183239
      Axin_b-cat_bind; Axin beta-catenin binding domain
    8. XM_017023746.1XP_016879235.1  

      Conserved Domains (2) summary
      pfam00778
      Location:432507
      DIX; DIX domain
      pfam08833
      Location:114170
      Axin_b-cat_bind; Axin beta-catenin binding domain
    9. XM_017023747.1XP_016879236.1  

    10. XM_017023748.1XP_016879237.1  

    RNA

    1. XR_001751996.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018927.2 Alternate CHM1_1.1

      Range
      337402..402637 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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