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    WISP3 WNT1 inducible signaling pathway protein 3 [ Homo sapiens (human) ]

    Gene ID: 8838, updated on 6-Aug-2017
    Official Symbol
    WISP3provided by HGNC
    Official Full Name
    WNT1 inducible signaling pathway protein 3provided by HGNC
    Primary source
    HGNC:HGNC:12771
    See related
    Ensembl:ENSG00000112761 MIM:603400; Vega:OTTHUMG00000185101
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PPD; CCN6; LIBC; PPAC; WISP-3
    Summary
    This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of this gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    6q21
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 6 NC_000006.12 (112052813..112069686)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (112375278..112390889)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2527 Neighboring gene uncharacterized LOC105377947 Neighboring gene tubulin epsilon 1 Neighboring gene family with sequence similarity 229 member B Neighboring gene uncharacterized LOC107986633 Neighboring gene laminin subunit alpha 4

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC125987, MGC125988, MGC125989

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    heparin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    insulin-like growth factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of cell death IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular space NAS
    Non-traceable Author Statement
    more info
    PubMed 
    proteinaceous extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    WNT1-inducible-signaling pathway protein 3
    Names
    CCN family member 6

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011748.1 RefSeqGene

      Range
      5001..20612
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003880.3NP_003871.1  WNT1-inducible-signaling pathway protein 3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_003871.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) has an alternate splice pattern near the 5' end and uses a downstream start codon, compared to variant 3. The resulting isoform (1) has a shorter N-terminus, compared to isoform 3.
      Source sequence(s)
      AL512299, BC012028, BC035250, BC105941
      Consensus CDS
      CCDS5098.1
      UniProtKB/Swiss-Prot
      O95389
      UniProtKB/TrEMBL
      I6L968
      Related
      ENSP00000230529.5, ENST00000230529.9
      Conserved Domains (2) summary
      pfam00219
      Location:48100
      IGFBP; Insulin-like growth factor binding protein
      cl21545
      Location:275341
      GHB_like; Glycoprotein hormone beta chain homologues
    2. NM_198239.1NP_937882.1  WNT1-inducible-signaling pathway protein 3 isoform 3

      See identical proteins and their annotated locations for NP_937882.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents the longer transcript and encodes the longer isoform (3).
      Source sequence(s)
      AF100781, BC035250
      Consensus CDS
      CCDS5097.1
      UniProtKB/Swiss-Prot
      O95389
      Related
      ENSP00000357655.3, OTTHUMP00000272966, ENST00000368666.6, OTTHUMT00000469559
      Conserved Domains (2) summary
      pfam00219
      Location:66118
      IGFBP; Insulin-like growth factor binding protein
      cl21545
      Location:293359
      GHB_like; Glycoprotein hormone beta chain homologues

    RNA

    1. NR_125353.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC035250, BC105940
      Related
      ENST00000368664.7, OTTHUMT00000469563
    2. NR_125354.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC012028, BC035250, BG928545
      Related
      ENST00000454589.5, OTTHUMT00000469560

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p7 Primary Assembly

      Range
      112052813..112069686
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011536222.2XP_011534524.2  WNT1-inducible-signaling pathway protein 3 isoform X3

    2. XM_011536220.1XP_011534522.1  WNT1-inducible-signaling pathway protein 3 isoform X1

      See identical proteins and their annotated locations for XP_011534522.1

      UniProtKB/Swiss-Prot
      O95389
      Conserved Domains (2) summary
      pfam00219
      Location:48100
      IGFBP; Insulin-like growth factor binding protein
      cl21545
      Location:275341
      GHB_like; Glycoprotein hormone beta chain homologues
    3. XM_011536223.2XP_011534525.1  WNT1-inducible-signaling pathway protein 3 isoform X2

      Conserved Domains (1) summary
      cl21545
      Location:81147
      GHB_like; Glycoprotein hormone beta chain homologues

    RNA

    1. XR_001743705.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018917.2 Alternate CHM1_1.1

      Range
      112637620..112653229
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_130396.1: Suppressed sequence

      Description
      NM_130396.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.
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