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    H2afx H2A histone family, member X [ Mus musculus (house mouse) ]

    Gene ID: 15270, updated on 9-Apr-2017
    Official Symbol
    H2afxprovided by MGI
    Official Full Name
    H2A histone family, member Xprovided by MGI
    Primary source
    MGI:MGI:102688
    See related
    Ensembl:ENSMUSG00000049932 Vega:OTTMUSG00000042356
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    H2ax; H2A.X; AW228881; Hist5-2ax; gammaH2ax
    Summary
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. [provided by RefSeq, Nov 2015]
    Orthologs
    Location:
    9 A5.2; 9 24.84 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (44334715..44336077)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (44142798..44144160)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene C2 calcium-dependent domain containing 2-like Neighboring gene dolichyl-phosphate (UDP-N-acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) Neighboring gene hydroxymethylbilane synthase Neighboring gene VPS11, CORVET/HOPS core subunit

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    damaged DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    NOT DNA damage checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA recombination IEA
    Inferred from Electronic Annotation
    more info
     
    DNA repair IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to gamma radiation ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin silencing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    XY body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleosome IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    replication fork IDA
    Inferred from Direct Assay
    more info
    PubMed 
    site of double-strand break IDA
    Inferred from Direct Assay
    more info
    PubMed 
    site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    histone H2AX
    Names
    H2a/x
    histone 5 protein 2ax
    histone H2A.x

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010436.2NP_034566.1  histone H2AX

      See identical proteins and their annotated locations for NP_034566.1

      Status: REVIEWED

      Source sequence(s)
      BC010336
      Consensus CDS
      CCDS23105.1
      UniProtKB/Swiss-Prot
      P27661
      Related
      ENSMUSP00000051432.2, OTTMUSP00000062531, ENSMUST00000052686.3, OTTMUST00000111622
      Conserved Domains (2) summary
      PTZ00017
      Location:1130
      PTZ00017; histone H2A; Provisional
      cd00074
      Location:6120
      H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      44334715..44336077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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