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    SIRT7 sirtuin 7 [ Homo sapiens (human) ]

    Gene ID: 51547, updated on 10-Dec-2017
    Official Symbol
    SIRT7provided by HGNC
    Official Full Name
    sirtuin 7provided by HGNC
    Primary source
    HGNC:HGNC:14935
    See related
    Ensembl:ENSG00000187531 MIM:606212; Vega:OTTHUMG00000177957
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SIR2L7
    Summary
    This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in stomach (RPKM 8.5), bone marrow (RPKM 8.5) and 25 other tissues See more
    Orthologs
    Location:
    17q25.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 17 NC_000017.11 (81911939..81918182, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79869815..79876058, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Aly/REF export factor Neighboring gene anaphase promoting complex subunit 11 Neighboring gene phosphate cytidylyltransferase 2, ethanolamine Neighboring gene neuropeptide B Neighboring gene MAF bZIP transcription factor G Neighboring gene MAFG antisense RNA 1 (head to head)

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC126840, MGC126842

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NAD+ binding IEA
    Inferred from Electronic Annotation
    more info
     
    NAD-dependent histone deacetylase activity (H3-K18 specific) IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    histone H3 deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone H4 deacetylation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription involved in exit from mitosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    rRNA transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus organizer region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    NAD-dependent protein deacetylase sirtuin-7
    Names
    NAD-dependent deacetylase sirtuin-7
    SIR2-like protein 7
    regulatory protein SIR2 homolog 7
    silent mating type information regulation 2, S.cerevisiae, homolog 7
    sir2-related protein type 7
    sirtuin type 7

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016538.2NP_057622.1  NAD-dependent protein deacetylase sirtuin-7

      See identical proteins and their annotated locations for NP_057622.1

      Status: REVIEWED

      Source sequence(s)
      BC017305, BC101791, BQ890203, CD579273
      Consensus CDS
      CCDS11792.1
      UniProtKB/Swiss-Prot
      Q9NRC8
      Related
      ENSP00000329466.6, OTTHUMP00000258199, ENST00000328666.10, OTTHUMT00000439961
      Conserved Domains (2) summary
      cd01410
      Location:100314
      SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...
      pfam07321
      Location:16101
      YscO; Type III secretion protein YscO

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p7 Primary Assembly

      Range
      81911939..81918182 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011523580.1XP_011521882.1  NAD-dependent protein deacetylase sirtuin-7 isoform X1

      See identical proteins and their annotated locations for XP_011521882.1

      Conserved Domains (1) summary
      cd01410
      Location:78279
      SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...
    2. XM_011523581.2XP_011521883.1  NAD-dependent protein deacetylase sirtuin-7 isoform X2

      Conserved Domains (1) summary
      cd01410
      Location:42243
      SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...
    3. XM_006722284.2XP_006722347.1  NAD-dependent protein deacetylase sirtuin-7 isoform X3

      Conserved Domains (1) summary
      cd01410
      Location:31232
      SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...

    RNA

    1. XR_430032.2 RNA Sequence

    2. XR_933936.1 RNA Sequence

      Related
      ENST00000536038.5

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      79956019..79962262 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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