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    Acaca acetyl-Coenzyme A carboxylase alpha [ Mus musculus (house mouse) ]

    Gene ID: 107476, updated on 4-Jun-2017
    Official Symbol
    Acacaprovided by MGI
    Official Full Name
    acetyl-Coenzyme A carboxylase alphaprovided by MGI
    Primary source
    MGI:MGI:108451
    See related
    Ensembl:ENSMUSG00000020532 Vega:OTTMUSG00000000985
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Acac; Acc1; Gm738; A530025K05Rik
    Orthologs
    Location:
    11; 11 C
    Exon count:
    58
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (84129677..84401651)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (84008940..84215153)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene dual specificity phosphatase 14 Neighboring gene transcriptional adaptor 2A Neighboring gene predicted gene 11437 Neighboring gene 60S ribosomal protein L35 pseudogene Neighboring gene uncharacterized LOC108167915 Neighboring gene apoptosis antagonizing transcription factor Neighboring gene LIM homeobox protein 1

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    acetyl-CoA carboxylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acetyl-CoA carboxylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acetyl-CoA carboxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    biotin binding ISO
    Inferred from Sequence Orthology
    more info
     
    biotin carboxylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acetyl-CoA metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acetyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to prostaglandin E stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fatty acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    lipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organismal protein metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
     
    tissue homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    acetyl-CoA carboxylase 1
    Names
    ACC-alpha
    acaca
    acetyl-CoA carboxylase 265
    NP_579938.2
    XP_006532016.1
    XP_006532017.1
    XP_006532018.1
    XP_006532019.1
    XP_006532020.1
    XP_006532021.1
    XP_011246968.1
    XP_011246969.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133360.2NP_579938.2  acetyl-CoA carboxylase 1

      See identical proteins and their annotated locations for NP_579938.2

      Status: VALIDATED

      Source sequence(s)
      AL596252, AY451393, BC056500, BY726813, CF745722, CN538919, CN705188
      Consensus CDS
      CCDS25185.1
      UniProtKB/Swiss-Prot
      Q5SWU9
      Related
      ENSMUSP00000020843.6, ENSMUST00000020843.12
      Conserved Domains (8) summary
      COG0439
      Location:117619
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:670817
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00289
      Location:117236
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam00364
      Location:752817
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:16682216
      Carboxyl_trans; Carboxyl transferase domain
      pfam02785
      Location:506613
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      pfam08326
      Location:8191568
      ACC_central; Acetyl-CoA carboxylase, central region
      cl17255
      Location:288469
      ATP-grasp_4; ATP-grasp domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      84129677..84401651
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531953.1XP_006532016.1  acetyl-CoA carboxylase 1 isoform X2

      UniProtKB/Swiss-Prot
      Q5SWU9
      Conserved Domains (8) summary
      COG0439
      Location:155657
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:708855
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00289
      Location:155274
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam00364
      Location:790855
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:17062254
      Carboxyl_trans; Carboxyl transferase domain
      pfam02785
      Location:544651
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      pfam08326
      Location:8571606
      ACC_central; Acetyl-CoA carboxylase, central region
      cl17255
      Location:326507
      ATP-grasp_4; ATP-grasp domain
    2. XM_011248667.1XP_011246969.1  acetyl-CoA carboxylase 1 isoform X3

      See identical proteins and their annotated locations for XP_011246969.1

      UniProtKB/Swiss-Prot
      Q5SWU9
      Conserved Domains (8) summary
      COG0439
      Location:117619
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:670817
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00289
      Location:117236
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam00364
      Location:752817
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:16682216
      Carboxyl_trans; Carboxyl transferase domain
      pfam02785
      Location:506613
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      pfam08326
      Location:8191568
      ACC_central; Acetyl-CoA carboxylase, central region
      cl17255
      Location:288469
      ATP-grasp_4; ATP-grasp domain
    3. XM_006531954.2XP_006532017.1  acetyl-CoA carboxylase 1 isoform X3

      See identical proteins and their annotated locations for XP_006532017.1

      UniProtKB/Swiss-Prot
      Q5SWU9
      Related
      ENSMUSP00000099490.1, OTTMUSP00000000931, ENSMUST00000103201.7, OTTMUST00000001932
      Conserved Domains (8) summary
      COG0439
      Location:117619
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:670817
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00289
      Location:117236
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam00364
      Location:752817
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:16682216
      Carboxyl_trans; Carboxyl transferase domain
      pfam02785
      Location:506613
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      pfam08326
      Location:8191568
      ACC_central; Acetyl-CoA carboxylase, central region
      cl17255
      Location:288469
      ATP-grasp_4; ATP-grasp domain
    4. XM_006531956.2XP_006532019.1  acetyl-CoA carboxylase 1 isoform X3

      See identical proteins and their annotated locations for XP_006532019.1

      UniProtKB/Swiss-Prot
      Q5SWU9
      Conserved Domains (8) summary
      COG0439
      Location:117619
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:670817
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00289
      Location:117236
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam00364
      Location:752817
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:16682216
      Carboxyl_trans; Carboxyl transferase domain
      pfam02785
      Location:506613
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      pfam08326
      Location:8191568
      ACC_central; Acetyl-CoA carboxylase, central region
      cl17255
      Location:288469
      ATP-grasp_4; ATP-grasp domain
    5. XM_006531957.3XP_006532020.1  acetyl-CoA carboxylase 1 isoform X3

      See identical proteins and their annotated locations for XP_006532020.1

      UniProtKB/Swiss-Prot
      Q5SWU9
      Conserved Domains (8) summary
      COG0439
      Location:117619
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:670817
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00289
      Location:117236
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam00364
      Location:752817
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:16682216
      Carboxyl_trans; Carboxyl transferase domain
      pfam02785
      Location:506613
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      pfam08326
      Location:8191568
      ACC_central; Acetyl-CoA carboxylase, central region
      cl17255
      Location:288469
      ATP-grasp_4; ATP-grasp domain
    6. XM_006531955.1XP_006532018.1  acetyl-CoA carboxylase 1 isoform X3

      See identical proteins and their annotated locations for XP_006532018.1

      UniProtKB/Swiss-Prot
      Q5SWU9
      Conserved Domains (8) summary
      COG0439
      Location:117619
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:670817
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00289
      Location:117236
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam00364
      Location:752817
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:16682216
      Carboxyl_trans; Carboxyl transferase domain
      pfam02785
      Location:506613
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      pfam08326
      Location:8191568
      ACC_central; Acetyl-CoA carboxylase, central region
      cl17255
      Location:288469
      ATP-grasp_4; ATP-grasp domain
    7. XM_011248666.1XP_011246968.1  acetyl-CoA carboxylase 1 isoform X1

      Conserved Domains (8) summary
      COG0439
      Location:117619
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:670817
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00289
      Location:117236
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam00364
      Location:752817
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:16602208
      Carboxyl_trans; Carboxyl transferase domain
      pfam02785
      Location:506613
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      pfam08326
      Location:8191560
      ACC_central; Acetyl-CoA carboxylase, central region
      cl17255
      Location:288469
      ATP-grasp_4; ATP-grasp domain
    8. XM_006531958.1XP_006532021.1  acetyl-CoA carboxylase 1 isoform X4

      Conserved Domains (7) summary
      COG4770
      Location:1646
      PccA; Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid transport and metabolism]
      pfam00289
      Location:167
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam00364
      Location:583648
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:14992047
      Carboxyl_trans; Carboxyl transferase domain
      pfam02785
      Location:337444
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      pfam08326
      Location:6501399
      ACC_central; Acetyl-CoA carboxylase, central region
      cl17255
      Location:119300
      ATP-grasp_4; ATP-grasp domain
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