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    Creb1 cAMP responsive element binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 12912, updated on 12-Mar-2017
    Official Symbol
    Creb1provided by MGI
    Official Full Name
    cAMP responsive element binding protein 1provided by MGI
    Primary source
    MGI:MGI:88494
    See related
    Ensembl:ENSMUSG00000025958 Vega:OTTMUSG00000047617
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Creb; Creb-1; AV083133; 2310001E10Rik; 3526402H21Rik
    Orthologs
    Location:
    1 C2; 1 32.74 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (64532315..64604548)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (64579378..64651122)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene predicted gene 28980 Neighboring gene predicted gene, 36148 Neighboring gene methyltransferase like 21A Neighboring gene predicted gene 29152

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II activating transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II core promoter proximal region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II distal enhancer sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    arrestin family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    cAMP response element binding ISO
    Inferred from Sequence Orthology
    more info
     
    double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone acetyltransferase binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor activity, sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor activity, sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcriptional activator activity, RNA polymerase II transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Type I pneumocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to hepatocyte growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to zinc ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chemotaxis to arachidonic acid ISO
    Inferred from Sequence Orthology
    more info
     
    circadian rhythm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lactation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lung epithelium development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lung saccule development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mammary gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription by competitive promoter binding ISO
    Inferred from Sequence Orthology
    more info
     
    pituitary gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of RNA polymerase II transcriptional preinitiation complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cardiac muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of fat cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of hormone secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of lipid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of long-term synaptic potentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of osteoclast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transforming growth factor beta3 production ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell size IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of glial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to drug IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to glucagon IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to organic substance ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    secretory granule organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    visual learning ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    ATF4-CREB1 transcription factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ATF4-CREB1 transcription factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear euchromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transcription factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    cyclic AMP-responsive element-binding protein 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037726.1NP_001032815.1  cyclic AMP-responsive element-binding protein 1 isoform C

      See identical proteins and their annotated locations for NP_001032815.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (C) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon, compared to variant A. The encoded protein (isoform C) has a shorter N-terminus, compared to isoform A.
      Source sequence(s)
      AC166336, AK044992, BY315899, CD776417
      Consensus CDS
      CCDS48280.1
      UniProtKB/TrEMBL
      Q543W0, Q62347
      Related
      ENSMUSP00000132860, OTTMUSP00000067235, ENSMUST00000171164, OTTMUST00000122763
      Conserved Domains (2) summary
      cd14690
      Location:231285
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:5997
      pKID; pKID domain
    2. NM_009952.2NP_034082.1  cyclic AMP-responsive element-binding protein 1 isoform B

      See identical proteins and their annotated locations for NP_034082.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (B) includes an alternate in-frame exon in the 5' coding region, compared to variant A, resulting in a longer protein (isoform B), compared to isoform A.
      Source sequence(s)
      AC124361, BB831364, BY315899, CD776417, M95106
      Consensus CDS
      CCDS15004.1
      UniProtKB/Swiss-Prot
      Q01147
      UniProtKB/TrEMBL
      Q547S9
      Related
      ENSMUSP00000140112, OTTMUSP00000067240, ENSMUST00000190348, OTTMUST00000122770
      Conserved Domains (2) summary
      cd14690
      Location:285339
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:113151
      pKID; pKID domain
    3. NM_133828.2NP_598589.2  cyclic AMP-responsive element-binding protein 1 isoform A

      See identical proteins and their annotated locations for NP_598589.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (A) encodes isoform A.
      Source sequence(s)
      AC124361, AK044992, BY315899, BY782293, CD776417
      Consensus CDS
      CCDS15005.1
      UniProtKB/Swiss-Prot
      Q01147
      UniProtKB/TrEMBL
      Q543W0
      Related
      ENSMUSP00000084624, OTTMUSP00000067238, ENSMUST00000087366, OTTMUST00000122767
      Conserved Domains (2) summary
      cd14690
      Location:271325
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:99137
      pKID; pKID domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      64532315..64604548
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006495653.3XP_006495716.1  cyclic AMP-responsive element-binding protein 1 isoform X6

      Conserved Domains (2) summary
      cd14690
      Location:224278
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:113151
      pKID; pKID domain
    2. XM_006495654.3XP_006495717.1  cyclic AMP-responsive element-binding protein 1 isoform X7

      Conserved Domains (2) summary
      cd14690
      Location:210264
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:99137
      pKID; pKID domain
    3. XM_017314080.1XP_017169569.1  cyclic AMP-responsive element-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q01147
      UniProtKB/TrEMBL
      Q547S9
      Conserved Domains (2) summary
      cd14690
      Location:285339
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:113151
      pKID; pKID domain
    4. XM_006495650.3XP_006495713.1  cyclic AMP-responsive element-binding protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006495713.1

      UniProtKB/Swiss-Prot
      Q01147
      UniProtKB/TrEMBL
      Q547S9
      Related
      ENSMUSP00000059973, OTTMUSP00000067237, ENSMUST00000049932, OTTMUST00000122766
      Conserved Domains (2) summary
      cd14690
      Location:285339
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:113151
      pKID; pKID domain
    5. XM_006495652.3XP_006495715.1  cyclic AMP-responsive element-binding protein 1 isoform X5

      See identical proteins and their annotated locations for XP_006495715.1

      Conserved Domains (2) summary
      cd14690
      Location:245299
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:73111
      pKID; pKID domain
    6. XM_006495651.3XP_006495714.1  cyclic AMP-responsive element-binding protein 1 isoform X4

      See identical proteins and their annotated locations for XP_006495714.1

      UniProtKB/Swiss-Prot
      Q01147
      UniProtKB/TrEMBL
      Q543W0
      Related
      ENSMUSP00000139995, OTTMUSP00000067234, ENSMUST00000185594, OTTMUST00000122762
      Conserved Domains (2) summary
      cd14690
      Location:271325
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:99137
      pKID; pKID domain
    7. XM_017314099.1XP_017169588.1  cyclic AMP-responsive element-binding protein 1 isoform X3

      UniProtKB/Swiss-Prot
      Q01147
      UniProtKB/TrEMBL
      Q543W0
      Conserved Domains (2) summary
      cd14690
      Location:271325
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:99137
      pKID; pKID domain
    8. XM_011238424.2XP_011236726.1  cyclic AMP-responsive element-binding protein 1 isoform X8

      See identical proteins and their annotated locations for XP_011236726.1

      Conserved Domains (1) summary
      cd14690
      Location:77131
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    9. XM_011238425.2XP_011236727.1  cyclic AMP-responsive element-binding protein 1 isoform X8

      See identical proteins and their annotated locations for XP_011236727.1

      Conserved Domains (1) summary
      cd14690
      Location:77131
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    10. XM_006495655.3XP_006495718.1  cyclic AMP-responsive element-binding protein 1 isoform X9

      Conserved Domains (1) summary
      cd14690
      Location:55109
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
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