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    Camp cathelicidin antimicrobial peptide [ Mus musculus (house mouse) ]

    Gene ID: 12796, updated on 22-Apr-2017
    Official Symbol
    Campprovided by MGI
    Official Full Name
    cathelicidin antimicrobial peptideprovided by MGI
    Primary source
    MGI:MGI:108443
    See related
    Ensembl:ENSMUSG00000038357 Vega:OTTMUSG00000020575
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cnlp; MCLP; CAP18; Cramp; FALL39
    Summary
    This gene encodes a member of the cathelicidin family of antimicrobial peptides that play an important role in the defense against microbial infection. The encoded preproprotein undergoes proteolytic processing to generate a mature polypeptide before secretion by host cells such as neutrophils, epithelial cells and macrophages. Mice lacking the encoded protein exhibit increased susceptibility to group A streptococcus and Escherichia coli infections. [provided by RefSeq, Oct 2015]
    Orthologs
    Location:
    9 F2; 9 59.8 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (109847377..109849456, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (109749891..109751970, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene NME/NM23 nucleoside diphosphate kinase 6 Neighboring gene predicted gene, 39427 Neighboring gene cell division cycle 25A Neighboring gene microRNA 7089

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
      NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • Salivary secretion, organism-specific biosystem (from KEGG)
      Salivary secretion, organism-specific biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
    • Salivary secretion, conserved biosystem (from KEGG)
      Salivary secretion, conserved biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    antibacterial humoral response ISO
    Inferred from Sequence Orthology
    more info
     
    antimicrobial humoral immune response mediated by antimicrobial peptide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response IEA
    Inferred from Electronic Annotation
    more info
     
    defense response to Gram-negative bacterium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response to Gram-negative bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    innate immune response in mucosa ISO
    Inferred from Sequence Orthology
    more info
     
    killing by host of symbiont cells IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    killing by host of symbiont cells ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of growth of symbiont in host IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of growth of symbiont on or near host surface IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of growth of symbiont on or near host surface ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cell projection ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    specific granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    specific granule ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    cathelicidin antimicrobial peptide
    Names
    CLP
    cathelin-like protein
    cathelin-related antimicrobial peptide

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009921.2NP_034051.2  cathelicidin antimicrobial peptide precursor

      See identical proteins and their annotated locations for NP_034051.2

      Status: REVIEWED

      Source sequence(s)
      BC120754, BY582734, U43409
      Consensus CDS
      CCDS52934.1
      UniProtKB/Swiss-Prot
      P51437
      Related
      ENSMUSP00000107653.2, OTTMUSP00000022449, ENSMUST00000112022.4, OTTMUST00000048760
      Conserved Domains (2) summary
      pfam00666
      Location:2995
      Cathelicidins; Cathelicidin
      pfam12153
      Location:140165
      CAP18_C; LPS binding domain of CAP18 (C terminal)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      109847377..109849456 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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