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    CLIC1 chloride intracellular channel 1 [ Homo sapiens (human) ]

    Gene ID: 1192, updated on 22-Apr-2017
    Official Symbol
    CLIC1provided by HGNC
    Official Full Name
    chloride intracellular channel 1provided by HGNC
    Primary source
    HGNC:HGNC:2062
    See related
    Ensembl:ENSG00000213719 MIM:602872; Vega:OTTHUMG00000031103
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    G6; CL1C1; NCC27
    Summary
    Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    6p21.33
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 6 NC_000006.12 (31730581..31737318, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (31698358..31705095, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene lymphocyte antigen 6 family member G6C Neighboring gene megakaryocyte and platelet inhibitory receptor G6b Neighboring gene dimethylarginine dimethylaminohydrolase 2 Neighboring gene uncharacterized LOC105375020 Neighboring gene MSH5-SAPCD1 readthrough (NMD candidate) Neighboring gene mutS homolog 5 Neighboring gene RNA, U6 small nuclear 850, pseudogene

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Expression of HIV-1 Tat upregulates the abundance of chloride intracellular channel 1 (CLIC1) in the nucleoli of Jurkat T-cells PubMed
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of chloride intracellular channel 1 (CLIC1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cadherin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chloride channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    voltage-gated ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    chloride transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    platelet aggregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of mitochondrial membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    blood microparticle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    brush border TAS
    Traceable Author Statement
    more info
    PubMed 
    chloride channel complex IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    chloride intracellular channel protein 1
    Names
    RNCC protein
    chloride channel ABP
    hRNCC
    nuclear chloride ion channel 27
    nuclear chloride ion channel protein
    p64CLCP
    regulatory nuclear chloride ion channel protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001287593.1NP_001274522.1  chloride intracellular channel protein 1

      See identical proteins and their annotated locations for NP_001274522.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      BC064527
      Consensus CDS
      CCDS4719.1
      UniProtKB/Swiss-Prot
      O00299
      UniProtKB/TrEMBL
      Q5SRT3
      Related
      ENSP00000364935.2, OTTHUMP00000174486, ENST00000375780.6, OTTHUMT00000076167
      Conserved Domains (3) summary
      TIGR00862
      Location:6241
      O-ClC; intracellular chloride channel protein
      cd10300
      Location:100238
      GST_C_CLIC1; C-terminal, alpha helical domain of Chloride Intracellular Channel 1
      cd03061
      Location:393
      GST_N_CLIC; GST_N family, Chloride Intracellular Channel (CLIC) subfamily; composed of CLIC1-5, p64, parchorin and similar proteins. They are auto-inserting, self-assembling intracellular anion channels involved in a wide variety of functions including regulated ...
    2. NM_001287594.1NP_001274523.1  chloride intracellular channel protein 1

      See identical proteins and their annotated locations for NP_001274523.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an alternate exon in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AI192421, AK223379, CB124154, CX783058, HY057217
      Consensus CDS
      CCDS4719.1
      UniProtKB/Swiss-Prot
      O00299
      UniProtKB/TrEMBL
      Q53FB0, Q5SRT3
      Related
      ENSP00000479808.1, ENST00000616760.1
      Conserved Domains (3) summary
      TIGR00862
      Location:6241
      O-ClC; intracellular chloride channel protein
      cd10300
      Location:100238
      GST_C_CLIC1; C-terminal, alpha helical domain of Chloride Intracellular Channel 1
      cd03061
      Location:393
      GST_N_CLIC; GST_N family, Chloride Intracellular Channel (CLIC) subfamily; composed of CLIC1-5, p64, parchorin and similar proteins. They are auto-inserting, self-assembling intracellular anion channels involved in a wide variety of functions including regulated ...
    3. NM_001288.4NP_001279.2  chloride intracellular channel protein 1

      See identical proteins and their annotated locations for NP_001279.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate exon in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      BC064527, BM562536, X87689
      Consensus CDS
      CCDS4719.1
      UniProtKB/Swiss-Prot
      O00299
      UniProtKB/TrEMBL
      Q5SRT3
      Related
      ENSP00000364940.3, OTTHUMP00000029131, ENST00000375784.7, OTTHUMT00000076166
      Conserved Domains (3) summary
      TIGR00862
      Location:6241
      O-ClC; intracellular chloride channel protein
      cd10300
      Location:100238
      GST_C_CLIC1; C-terminal, alpha helical domain of Chloride Intracellular Channel 1
      cd03061
      Location:393
      GST_N_CLIC; GST_N family, Chloride Intracellular Channel (CLIC) subfamily; composed of CLIC1-5, p64, parchorin and similar proteins. They are auto-inserting, self-assembling intracellular anion channels involved in a wide variety of functions including regulated ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p7 Primary Assembly

      Range
      31730581..31737318 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p7 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.3 Reference GRCh38.p7 ALT_REF_LOCI_2

      Range
      3207869..3214610 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p7 ALT_REF_LOCI_3

    Genomic

    1. NT_167245.2 Reference GRCh38.p7 ALT_REF_LOCI_3

      Range
      2978342..2985081 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p7 ALT_REF_LOCI_4

    Genomic

    1. NT_167246.2 Reference GRCh38.p7 ALT_REF_LOCI_4

      Range
      3035628..3042369 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p7 ALT_REF_LOCI_5

    Genomic

    1. NT_167247.2 Reference GRCh38.p7 ALT_REF_LOCI_5

      Range
      3072456..3079197 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p7 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.2 Reference GRCh38.p7 ALT_REF_LOCI_6

      Range
      2986392..2993137 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p7 ALT_REF_LOCI_7

    Genomic

    1. NT_167249.2 Reference GRCh38.p7 ALT_REF_LOCI_7

      Range
      3029877..3036620 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018917.2 Alternate CHM1_1.1

      Range
      31700475..31707209 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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