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    lexA transcriptional repressor of SOS regulon [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948544, updated on 25-May-2017
    Gene symbol
    lexA
    Gene description
    transcriptional repressor of SOS regulon
    Primary source
    EcoGene:EG10533
    Locus tag
    b4043
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4035; exrA; JW4003; spr; tsl; umuA
    Summary
    LexA autocleavage, stimulated by RecA, of the first 84 aa of LexA removes the DNA binding region and is required to activate the SOS response. [More information is available at EcoGene: EG10533]. LexA is a protein that belongs to the LexA family . [More information is available at EcoCyc: EG10533].
    Sequence:
    NC_000913.3 (4257115..4257723)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene glycerol-3-phosphate O-acyltransferase Neighboring gene diacylglycerol kinase Neighboring gene oxidative stress resistance protein; putative MATE family efflux pump; UV and mitomycin C inducible protein Neighboring gene stress-induced protein, UPF0337 family

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    SOS response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to DNA damage stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Names
    transcriptional repressor of SOS regulon
    NP_418467.1
    • regulator for SOS(lexA) regulon

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4257115..4257723
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418467.1 transcriptional repressor of SOS regulon [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418467.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P0A7C2
      Conserved Domains (3) summary
      cd06529
      Location:111180
      S24_LexA-like; Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC ...
      pfam01726
      Location:365
      LexA_DNA_bind; LexA DNA binding domain
      PRK00215
      Location:3199
      PRK00215; LexA repressor; Validated
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