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    Shank1 SH3 and multiple ankyrin repeat domains 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 78957, updated on 25-Jun-2017
    Official Symbol
    Shank1provided by RGD
    Official Full Name
    SH3 and multiple ankyrin repeat domains 1provided by RGD
    Primary source
    RGD:621011
    See related
    Ensembl:ENSRNOG00000019207 Vega:OTTRNOG00000002180
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Spank1; Sstrip; Shank1a
    Summary
    a scaffold protein in the post synaptic density that forms a complex with GKAP and PSD-95 [RGD, Feb 2006]
    Orthologs
    Location:
    1q22
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (100297137..100344377)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (101362243..101410338)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 32 Neighboring gene C-type lectin domain containing 11A Neighboring gene hypothetical LOC292874 Neighboring gene synaptotagmin 3

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    GKAP/Homer scaffold activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GKAP/Homer scaffold activity ISO
    Inferred from Sequence Orthology
    more info
     
    SH3 domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ankyrin repeat binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ionotropic glutamate receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ionotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor signaling complex scaffold activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    scaffold protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    somatostatin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    adult behavior IEA
    Inferred from Electronic Annotation
    more info
     
    adult behavior ISO
    Inferred from Sequence Orthology
    more info
     
    associative learning ISO
    Inferred from Sequence Orthology
    more info
     
    associative learning ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoskeletal anchoring at plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    dendritic spine morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    determination of affect IEA
    Inferred from Electronic Annotation
    more info
     
    determination of affect ISO
    Inferred from Sequence Orthology
    more info
     
    habituation ISO
    Inferred from Sequence Orthology
    more info
     
    habituation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    long-term memory ISO
    Inferred from Sequence Orthology
    more info
     
    long-term memory ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of actin filament bundle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of actin filament bundle assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuromuscular process controlling balance ISO
    Inferred from Sequence Orthology
    more info
     
    neuromuscular process controlling balance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    olfactory behavior ISO
    Inferred from Sequence Orthology
    more info
     
    olfactory behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of dendritic spine development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of excitatory postsynaptic potential ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein localization to synapse ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of AMPA receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of AMPA receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    righting reflex ISO
    Inferred from Sequence Orthology
    more info
     
    righting reflex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    social behavior IEA
    Inferred from Electronic Annotation
    more info
     
    social behavior ISO
    Inferred from Sequence Orthology
    more info
     
    synapse maturation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    vocalization behavior IEA
    Inferred from Electronic Annotation
    more info
     
    vocalization behavior ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    colocalizes_with NMDA selective glutamate receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite NAS
    Non-traceable Author Statement
    more info
    PubMed 
    dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    excitatory synapse ISO
    Inferred from Sequence Orthology
    more info
     
    excitatory synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    intracellular NAS
    Non-traceable Author Statement
    more info
    PubMed 
    colocalizes_with ionotropic glutamate receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with ionotropic glutamate receptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    postsynaptic density of dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density of dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    SH3 and multiple ankyrin repeat domains protein 1
    Names
    GKAP/SAPAP-interacting protein
    SAPAP-interacting protein synamon
    SH3/ankyrin domain gene 1
    SPANK-1
    SSTR-interacting protein
    somatostatin receptor-interacting protein
    synamon

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031751.3NP_113939.2  SH3 and multiple ankyrin repeat domains protein 1

      See identical proteins and their annotated locations for NP_113939.2

      Status: PROVISIONAL

      Source sequence(s)
      AF159046
      UniProtKB/Swiss-Prot
      Q9WV48
      Related
      ENSRNOP00000026100.3, OTTRNOP00000002108, ENSRNOT00000026100.5, OTTRNOT00000003668
      Conserved Domains (8) summary
      cd09506
      Location:21002165
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      smart00454
      Location:21032167
      SAM; Sterile alpha motif
      cd00204
      Location:274399
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd00992
      Location:661754
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12796
      Location:285377
      Ank_2; Ankyrin repeats (3 copies)
      pfam16511
      Location:73156
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      sd00045
      Location:279311
      ANK; ANK repeat [structural motif]
      cl17036
      Location:557608
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      100297137..100344377
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017589759.1XP_017445248.1  SH3 and multiple ankyrin repeat domains protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q9WV48
      Related
      ENSRNOP00000075838.1, OTTRNOP00000002109, ENSRNOT00000092327.1, OTTRNOT00000003669
      Conserved Domains (8) summary
      cd09506
      Location:20922157
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      smart00454
      Location:20952159
      SAM; Sterile alpha motif
      cd00204
      Location:274399
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd00992
      Location:661754
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12796
      Location:285377
      Ank_2; Ankyrin repeats (3 copies)
      pfam16511
      Location:73156
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      sd00045
      Location:279311
      ANK; ANK repeat [structural motif]
      cl17036
      Location:557608
      SH3; Src Homology 3 domain superfamily
    2. XM_017589760.1XP_017445249.1  SH3 and multiple ankyrin repeat domains protein 1 isoform X3

      UniProtKB/Swiss-Prot
      Q9WV48
      Related
      ENSRNOP00000039860.3, OTTRNOP00000002110, ENSRNOT00000044257.5, OTTRNOT00000003670
      Conserved Domains (8) summary
      cd09506
      Location:20912156
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      smart00454
      Location:20942158
      SAM; Sterile alpha motif
      cd00204
      Location:274399
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd00992
      Location:652745
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12796
      Location:285377
      Ank_2; Ankyrin repeats (3 copies)
      pfam16511
      Location:73156
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      sd00045
      Location:279311
      ANK; ANK repeat [structural motif]
      cl17036
      Location:557608
      SH3; Src Homology 3 domain superfamily
    3. XM_017589761.1XP_017445250.1  SH3 and multiple ankyrin repeat domains protein 1 isoform X5

      UniProtKB/Swiss-Prot
      Q9WV48
      Conserved Domains (6) summary
      cd00204
      Location:274399
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd00992
      Location:661754
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12796
      Location:285377
      Ank_2; Ankyrin repeats (3 copies)
      pfam16511
      Location:73156
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      sd00045
      Location:279311
      ANK; ANK repeat [structural motif]
      cl17036
      Location:557608
      SH3; Src Homology 3 domain superfamily
    4. XM_008759416.2XP_008757638.1  SH3 and multiple ankyrin repeat domains protein 1 isoform X4

      Conserved Domains (6) summary
      cd00204
      Location:274399
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd00992
      Location:661754
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12796
      Location:285377
      Ank_2; Ankyrin repeats (3 copies)
      pfam16511
      Location:73156
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      sd00045
      Location:279311
      ANK; ANK repeat [structural motif]
      cl17036
      Location:557608
      SH3; Src Homology 3 domain superfamily
    5. XM_017589758.1XP_017445247.1  SH3 and multiple ankyrin repeat domains protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q9WV48

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      89071051..89118344
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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