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    Mme membrane metallo endopeptidase [ Mus musculus (house mouse) ]

    Gene ID: 17380, updated on 6-Aug-2017
    Official Symbol
    Mmeprovided by MGI
    Official Full Name
    membrane metallo endopeptidaseprovided by MGI
    Primary source
    MGI:MGI:97004
    See related
    Ensembl:ENSMUSG00000027820 Vega:OTTMUSG00000051889
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NEP; SFE; CD10; CALLA; C85356; 6030454K05Rik
    Orthologs
    Location:
    3 E1; 3 29.97 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (63295224..63383713)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (63099794..63186153)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene chloride intracellular channel 4 (mitochondrial) pseudogene Neighboring gene predicted gene, 40064 Neighboring gene predicted gene, 34240 Neighboring gene predicted gene, 34302

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Alzheimer's disease, organism-specific biosystem (from KEGG)
      Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Alzheimer's disease, conserved biosystem (from KEGG)
      Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Alzheimers Disease, organism-specific biosystem (from WikiPathways)
      Alzheimers Disease, organism-specific biosystemThis pathway displays current genes, proteolytic events and other processes associated with the progression of Alzheimer's disease. This pathway was adapted from KEGG on 10/7/2011. Note: mitochondria...
    • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
      Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hematopoietic cell lineage, conserved biosystem (from KEGG)
      Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Metabolism of Angiotensinogen to Angiotensins, organism-specific biosystem (from REACTOME)
      Metabolism of Angiotensinogen to Angiotensins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
      Neutrophil degranulation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Peptide hormone metabolism, organism-specific biosystem (from REACTOME)
      Peptide hormone metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Primary Focal Segmental Glomerulosclerosis FSGS, organism-specific biosystem (from WikiPathways)
      Primary Focal Segmental Glomerulosclerosis FSGS, organism-specific biosystemPrimary or idiopathic focal segmental glomerulosclerosis (FSGS) a cause of nephrotic syndrome in children and adolescents, as well as an important cause of end stage renal disease in adults. FSGS is ...
    • Protein digestion and absorption, organism-specific biosystem (from KEGG)
      Protein digestion and absorption, organism-specific biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
    • Protein digestion and absorption, conserved biosystem (from KEGG)
      Protein digestion and absorption, conserved biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
    • Renin-angiotensin system, organism-specific biosystem (from KEGG)
      Renin-angiotensin system, organism-specific biosystemThe renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the ...
    • Renin-angiotensin system, conserved biosystem (from KEGG)
      Renin-angiotensin system, conserved biosystemThe renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the ...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    exopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    metallopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptide binding ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    amyloid-beta metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to UV-A ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to UV-B ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to cytokine stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    creatinine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    peptide metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    brush border ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection terminus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    neprilysin
    Names
    atriopeptidase
    common acute lymphoblastic leukemia antigen
    enkephalinase
    neutral endopeptidase 24.11
    skin fibroblast elastase
    NP_001276391.1
    NP_001276392.1
    NP_032630.2
    XP_006501158.1
    XP_006501161.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289462.1NP_001276391.1  neprilysin

      See identical proteins and their annotated locations for NP_001276391.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      AC121840, AK031446, AK076908, BY145991
      Consensus CDS
      CCDS17381.1
      UniProtKB/Swiss-Prot
      Q61391
      Related
      ENSMUSP00000141544.1, OTTMUSP00000069987, ENSMUST00000194150.5, OTTMUST00000130649
      Conserved Domains (2) summary
      cd08662
      Location:77748
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      COG3590
      Location:72750
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
    2. NM_001289463.1NP_001276392.1  neprilysin

      See identical proteins and their annotated locations for NP_001276392.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AC121840, AC121993, AK031446, AK033824
      Consensus CDS
      CCDS17381.1
      UniProtKB/Swiss-Prot
      Q61391
      Related
      ENSMUSP00000029400.1, OTTMUSP00000069989, ENSMUST00000029400.6, OTTMUST00000130651
      Conserved Domains (2) summary
      cd08662
      Location:77748
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      COG3590
      Location:72750
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
    3. NM_008604.4NP_032630.2  neprilysin

      See identical proteins and their annotated locations for NP_032630.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AC121840, AK031446
      Consensus CDS
      CCDS17381.1
      UniProtKB/Swiss-Prot
      Q61391
      Related
      ENSMUSP00000142205.1, OTTMUSP00000069988, ENSMUST00000194134.5, OTTMUST00000130650
      Conserved Domains (2) summary
      cd08662
      Location:77748
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      COG3590
      Location:72750
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      63295224..63383713
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501095.3XP_006501158.1  neprilysin isoform X1

      See identical proteins and their annotated locations for XP_006501158.1

      UniProtKB/Swiss-Prot
      Q61391
      Conserved Domains (2) summary
      cd08662
      Location:77748
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      COG3590
      Location:72750
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
    2. XM_006501098.3XP_006501161.1  neprilysin isoform X1

      See identical proteins and their annotated locations for XP_006501161.1

      UniProtKB/Swiss-Prot
      Q61391
      Conserved Domains (2) summary
      cd08662
      Location:77748
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      COG3590
      Location:72750
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
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