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    EBAG9 estrogen receptor binding site associated, antigen, 9 [ Homo sapiens (human) ]

    Gene ID: 9166, updated on 8-Oct-2017
    Official Symbol
    EBAG9provided by HGNC
    Official Full Name
    estrogen receptor binding site associated, antigen, 9provided by HGNC
    Primary source
    HGNC:HGNC:3123
    See related
    Ensembl:ENSG00000147654 MIM:605772; Vega:OTTHUMG00000165346
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EB9; PDAF
    Summary
    This gene was identified as an estrogen-responsive gene. Regulation of transcription by estrogen is mediated by estrogen receptor, which binds to the estrogen-responsive element found in the 5'-flanking region of this gene. The encoded protein is a tumor-associated antigen that is expressed at high frequency in a variety of cancers. Alternate splicing results in multiple transcript variants. A pseudogene of this gene has been defined on chromosome 10. [provided by RefSeq, Jul 2013]
    Orthologs
    Location:
    8q23.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 8 NC_000008.11 (109539700..109565996)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (110551929..110578225)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene PKHD1 like 1 Neighboring gene suppressor of cytokine signaling 5 pseudogene Neighboring gene mitogen-activated protein kinase 6 pseudogene 5 Neighboring gene syntabulin Neighboring gene uncharacterized LOC100132813 Neighboring gene SMG5 nonsense mediated mRNA decay factor pseudogene

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat significantly increases the mRNA transcription levels and the secretion of soluble RCAS1 in CD4(+) T cells and monocytes. Tat-mediated apoptosis is blocked by inhibiting the expression of RCAS1 PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    peptidase activator activity involved in apoptotic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell growth NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    secretory granule IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    receptor-binding cancer antigen expressed on SiSo cells
    Names
    cancer-associated surface antigen RCAS1
    estrogen receptor-binding fragment-associated gene 9 protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278938.1NP_001265867.1  receptor-binding cancer antigen expressed on SiSo cells

      See identical proteins and their annotated locations for NP_001265867.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AA812215, AI619447, BC017729, BC022506, BG616704
      Consensus CDS
      CCDS6313.1
      UniProtKB/Swiss-Prot
      O00559
      UniProtKB/TrEMBL
      A0A024R9E0
      Related
      ENSP00000477645.1, ENST00000620557.4
      Conserved Domains (1) summary
      pfam07946
      Location:160203
      DUF1682; Protein of unknown function (DUF1682)
    2. NM_004215.4NP_004206.1  receptor-binding cancer antigen expressed on SiSo cells

      See identical proteins and their annotated locations for NP_004206.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AA812215, AI619447, BC022506, BI194881, CD108096
      Consensus CDS
      CCDS6313.1
      UniProtKB/Swiss-Prot
      O00559
      UniProtKB/TrEMBL
      A0A024R9E0
      Related
      ENSP00000337675.5, OTTHUMP00000229416, ENST00000337573.9, OTTHUMT00000383536
      Conserved Domains (1) summary
      pfam07946
      Location:160203
      DUF1682; Protein of unknown function (DUF1682)
    3. NM_198120.2NP_936056.1  receptor-binding cancer antigen expressed on SiSo cells

      See identical proteins and their annotated locations for NP_936056.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AA812215, AI619447, BC017729, BC022506, BG707115
      Consensus CDS
      CCDS6313.1
      UniProtKB/Swiss-Prot
      O00559
      UniProtKB/TrEMBL
      A0A024R9E0
      Related
      ENSP00000379131.2, OTTHUMP00000230543, ENST00000395785.6, OTTHUMT00000385482
      Conserved Domains (1) summary
      pfam07946
      Location:160203
      DUF1682; Protein of unknown function (DUF1682)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p7 Primary Assembly

      Range
      109539700..109565996
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017013960.1XP_016869449.1  receptor-binding cancer antigen expressed on SiSo cells isoform X1

      UniProtKB/Swiss-Prot
      O00559
      UniProtKB/TrEMBL
      A0A024R9E0
      Related
      ENSP00000432082.1, OTTHUMP00000230548, ENST00000531677.5, OTTHUMT00000385488
      Conserved Domains (1) summary
      pfam07946
      Location:160203
      DUF1682; Protein of unknown function (DUF1682)

    Alternate CHM1_1.1

    Genomic

    1. NC_018919.2 Alternate CHM1_1.1

      Range
      110592186..110618469
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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