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    Acacb acetyl-Coenzyme A carboxylase beta [ Mus musculus (house mouse) ]

    Gene ID: 100705, updated on 9-Apr-2017
    Official Symbol
    Acacbprovided by MGI
    Official Full Name
    acetyl-Coenzyme A carboxylase betaprovided by MGI
    Primary source
    MGI:MGI:2140940
    See related
    Ensembl:ENSMUSG00000042010 Vega:OTTMUSG00000014407
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Acc2; Accb; AI597064; AW743042
    Orthologs
    Location:
    5; 5 F
    Exon count:
    56
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (114146321..114250761)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (114615527..114700767)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 30 Neighboring gene legumain pseudogene Neighboring gene alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase Neighboring gene uracil DNA glycosylase Neighboring gene forkhead box N4 Neighboring gene myosin 1H Neighboring gene potassium channel tetramerisation domain containing 10

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    acetyl-CoA carboxylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acetyl-CoA carboxylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acetyl-CoA carboxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    biotin binding ISO
    Inferred from Sequence Orthology
    more info
     
    biotin carboxylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acetyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    energy homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    malonyl-CoA biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of catalytic activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of fatty acid beta-oxidation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of fatty acid oxidation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of lipid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of heart growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of glucose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to nutrient levels IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    acetyl-CoA carboxylase 2
    Names
    ACC-beta
    NP_598665.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133904.2NP_598665.2  acetyl-CoA carboxylase 2 precursor

      See identical proteins and their annotated locations for NP_598665.2

      Status: VALIDATED

      Source sequence(s)
      AC122282, AF290178, AI597064, AK147463, AY451394
      Consensus CDS
      CCDS19561.1
      UniProtKB/Swiss-Prot
      E9Q4Z2
      UniProtKB/TrEMBL
      Q3UHC8, Q9ESZ3
      Related
      ENSMUSP00000031583.8, ENSMUST00000031583.14
      Conserved Domains (8) summary
      COG0439
      Location:250753
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:835953
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00289
      Location:250369
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam00364
      Location:885951
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:17702324
      Carboxyl_trans; Carboxyl transferase domain
      pfam02785
      Location:640747
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      pfam08326
      Location:9521678
      ACC_central; Acetyl-CoA carboxylase, central region
      cl17255
      Location:422603
      ATP-grasp_4; ATP-grasp domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      114146321..114250761
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530111.3XP_006530174.1  acetyl-CoA carboxylase 2 isoform X1

      See identical proteins and their annotated locations for XP_006530174.1

      Conserved Domains (8) summary
      COG0439
      Location:250753
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:835953
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00289
      Location:250369
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam00364
      Location:885951
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:17912345
      Carboxyl_trans; Carboxyl transferase domain
      pfam02785
      Location:640747
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      pfam08326
      Location:9521699
      ACC_central; Acetyl-CoA carboxylase, central region
      cl17255
      Location:422603
      ATP-grasp_4; ATP-grasp domain
    2. XM_006530113.3XP_006530176.1  acetyl-CoA carboxylase 2 isoform X2

      See identical proteins and their annotated locations for XP_006530176.1

      UniProtKB/Swiss-Prot
      E9Q4Z2
      Related
      ENSMUSP00000099642.1, OTTMUSP00000015299, ENSMUST00000102582.7, OTTMUST00000034129
      Conserved Domains (8) summary
      COG0439
      Location:250753
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:835953
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00289
      Location:250369
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam00364
      Location:885951
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:17702324
      Carboxyl_trans; Carboxyl transferase domain
      pfam02785
      Location:640747
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      pfam08326
      Location:9521678
      ACC_central; Acetyl-CoA carboxylase, central region
      cl17255
      Location:422603
      ATP-grasp_4; ATP-grasp domain
    3. XM_006530112.3XP_006530175.1  acetyl-CoA carboxylase 2 isoform X1

      See identical proteins and their annotated locations for XP_006530175.1

      Conserved Domains (8) summary
      COG0439
      Location:250753
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:835953
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00289
      Location:250369
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam00364
      Location:885951
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:17912345
      Carboxyl_trans; Carboxyl transferase domain
      pfam02785
      Location:640747
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      pfam08326
      Location:9521699
      ACC_central; Acetyl-CoA carboxylase, central region
      cl17255
      Location:422603
      ATP-grasp_4; ATP-grasp domain
    4. XM_006530114.3XP_006530177.1  acetyl-CoA carboxylase 2 isoform X3

      Conserved Domains (8) summary
      COG0439
      Location:58561
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:643761
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00289
      Location:58177
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam00364
      Location:693759
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:15992153
      Carboxyl_trans; Carboxyl transferase domain
      pfam02785
      Location:448555
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      pfam08326
      Location:7601507
      ACC_central; Acetyl-CoA carboxylase, central region
      cl17255
      Location:230411
      ATP-grasp_4; ATP-grasp domain
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