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    Adra1b adrenergic receptor, alpha 1b [ Mus musculus (house mouse) ]

    Gene ID: 11548, updated on 12-Mar-2017
    Official Symbol
    Adra1bprovided by MGI
    Official Full Name
    adrenergic receptor, alpha 1bprovided by MGI
    Primary source
    MGI:MGI:104774
    See related
    Ensembl:ENSMUSG00000050541 Vega:OTTMUSG00000005462
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    [a]1b
    Orthologs
    Location:
    11 B1.1; 11 25.81 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (43774605..43901245, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (43588108..43649834, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 34963 Neighboring gene PWWP domain containing 2A Neighboring gene tetratricopeptide repeat domain 1 Neighboring gene predicted gene 12153 Neighboring gene interleukin 12b

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    G-protein coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    adrenergic receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    alpha1-adrenergic receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    alpha1-adrenergic receptor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    alpha1-adrenergic receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    alpha1-adrenergic receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    signal transducer activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    adenylate cyclase-activating adrenergic receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    adult heart development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    behavioral response to cocaine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    blood vessel remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell growth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell-cell signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of glycogen catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    organ growth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    phospholipase C-activating G-protein coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glycogen catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of heart rate by epinephrine-norepinephrine IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of smooth muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of the force of heart contraction by epinephrine-norepinephrine IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of vasoconstriction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of cardiac muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
     
    response to amphetamine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to hormone ISO
    Inferred from Sequence Orthology
    more info
     
    response to morphine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to steroid hormone ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    visual learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    T-tubule ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    intercalated disc ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    alpha-1B adrenergic receptor
    Names
    alpha-1B adrenoceptor
    alpha-1B adrenoreceptor
    alpha1B-adrenergic receptor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001284380.1NP_001271309.1  alpha-1B adrenergic receptor

      See identical proteins and their annotated locations for NP_001271309.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK043877, BY107791, CA319459
      Consensus CDS
      CCDS24562.1
      UniProtKB/TrEMBL
      Q9DBL0
      Related
      ENSMUSP00000123435, OTTMUSP00000005617, ENSMUST00000139906, OTTMUST00000012163
      Conserved Domains (2) summary
      pfam00001
      Location:62348
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:56363
      7tm_4; Olfactory receptor
    2. NM_001284381.1NP_001271310.1  alpha-1B adrenergic receptor

      See identical proteins and their annotated locations for NP_001271310.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK004891, AK043877, BY107791, CA319459
      Consensus CDS
      CCDS24562.1
      UniProtKB/TrEMBL
      Q9DBL0
      Related
      ENSMUSP00000070200, OTTMUSP00000005616, ENSMUST00000067258, OTTMUST00000012162
      Conserved Domains (2) summary
      pfam00001
      Location:62348
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:56363
      7tm_4; Olfactory receptor
    3. NM_007416.4NP_031442.2  alpha-1B adrenergic receptor

      See identical proteins and their annotated locations for NP_031442.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK043877, AK139448, CA319459
      Consensus CDS
      CCDS24562.1
      UniProtKB/TrEMBL
      Q9DBL0
      Related
      ENSMUSP00000129200, ENSMUST00000167574
      Conserved Domains (2) summary
      pfam00001
      Location:62348
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:56363
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      43774605..43901245 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248675.2XP_011246977.1  alpha-1B adrenergic receptor isoform X1

      See identical proteins and their annotated locations for XP_011246977.1

      UniProtKB/TrEMBL
      Q9DBL0
      Conserved Domains (2) summary
      pfam00001
      Location:62348
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:56363
      7tm_4; Olfactory receptor
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