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    ACKR2 atypical chemokine receptor 2 [ Homo sapiens (human) ]

    Gene ID: 1238, updated on 6-Aug-2017
    Official Symbol
    ACKR2provided by HGNC
    Official Full Name
    atypical chemokine receptor 2provided by HGNC
    Primary source
    HGNC:HGNC:1565
    See related
    Ensembl:ENSG00000144648 MIM:602648; Vega:OTTHUMG00000186377
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    D6; hD6; CCR9; CCBP2; CCR10; CMKBR9
    Summary
    This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    3p22.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 3 NC_000003.12 (42809472..42867283)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (42850964..42908775)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 13 Neighboring gene long intergenic non-protein coding RNA 2158 Neighboring gene HIG1 hypoxia inducible domain family member 1A Neighboring gene coiled-coil domain containing 58 pseudogene 4 Neighboring gene cytochrome P450 family 8 subfamily B member 1 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 22

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
    NHGRI GWA Catalog
    Genetic variation associated with circulating monocyte count in the eMERGE Network.
    NHGRI GWA Catalog
    Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation.
    NHGRI GWA Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env A promiscuous CC chemokine receptor, D6, can function as a coreceptor for various primary dual-tropic isolates of HIV-1 and HIV-2 through binding to the viral gp120 protein PubMed

    Go to the HIV-1, Human Interaction Database

    • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
      GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC126678, MGC138250

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    C-C chemokine binding IEA
    Inferred from Electronic Annotation
    more info
     
    C-C chemokine receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    chemokine receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    scavenger receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    chemokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism development TAS
    Traceable Author Statement
    more info
    PubMed 
    receptor-mediated endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    actin filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    early endosome IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    nuclear membrane IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    recycling endosome IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    atypical chemokine receptor 2
    Names
    C-C chemokine receptor D6
    CC-chemokine-binding receptor JAB61
    chemokine (C-C motif) receptor 9
    chemokine (C-C) receptor 9
    chemokine receptor CCR-10
    chemokine receptor CCR-9
    chemokine receptor D6
    chemokine-binding protein 2
    chemokine-binding protein D6

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001296.4NP_001287.2  atypical chemokine receptor 2

      See identical proteins and their annotated locations for NP_001287.2

      Status: REVIEWED

      Source sequence(s)
      BC008816, DA853159
      Consensus CDS
      CCDS2706.1
      UniProtKB/Swiss-Prot
      O00590
      UniProtKB/TrEMBL
      A0A024R2X7
      Related
      ENSP00000416996.1, OTTHUMP00000164034, ENST00000422265.5, OTTHUMT00000256645
      Conserved Domains (1) summary
      PHA03087
      Location:10327
      PHA03087; G protein-coupled chemokine receptor-like protein; Provisional

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p7 Primary Assembly

      Range
      42809472..42867283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018914.2 Alternate CHM1_1.1

      Range
      42800945..42858775
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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