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    GAST gastrin [ Homo sapiens (human) ]

    Gene ID: 2520, updated on 5-Nov-2017
    Official Symbol
    GASTprovided by HGNC
    Official Full Name
    gastrinprovided by HGNC
    Primary source
    HGNC:HGNC:4164
    See related
    Ensembl:ENSG00000184502 MIM:137250; Vega:OTTHUMG00000133496
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GAS
    Summary
    Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms, G34 and G17. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward stomach (RPKM 4383.1) See more
    Orthologs
    Location:
    17q21.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 17 NC_000017.11 (41712326..41715969)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39868578..39872221)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene keratin 42 pseudogene Neighboring gene eukaryotic translation initiation factor 1 Neighboring gene RNA, 5S ribosomal pseudogene 442 Neighboring gene huntingtin associated protein 1 Neighboring gene RNA, 7SL, cytoplasmic 399, pseudogene

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • Gastric acid production, organism-specific biosystem (from WikiPathways)
      Gastric acid production, organism-specific biosystemGastric acid forms a protective buffer against pathogenic agents. It is also essential in the digestion of the food. The stomach wall is protected to the high acidity by a mucus layer and bicarbonate...
    • Gastric acid secretion, organism-specific biosystem (from KEGG)
      Gastric acid secretion, organism-specific biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
    • Gastric acid secretion, conserved biosystem (from KEGG)
      Gastric acid secretion, conserved biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
    • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
      Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
    • Secretion of Hydrochloric Acid in Parietal Cells, organism-specific biosystem (from WikiPathways)
      Secretion of Hydrochloric Acid in Parietal Cells, organism-specific biosystemGastric parietal cells are stomach epithelial cells. They secrete gastric acid and intrinsic factor. This pathway is primarily based on https://en.wikipedia.org/wiki/Parietal_cell
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    G-protein coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    regulation of receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    response to food IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    signal transduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    gastrin
    Names
    preprogastrin

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000805.4NP_000796.1  gastrin preproprotein

      See identical proteins and their annotated locations for NP_000796.1

      Status: REVIEWED

      Source sequence(s)
      BC069724, BM768483, BM768762
      Consensus CDS
      CCDS11404.1
      UniProtKB/Swiss-Prot
      P01350
      UniProtKB/TrEMBL
      A0A0E3VY36
      Related
      ENSP00000331358.3, OTTHUMP00000164741, ENST00000329402.3, OTTHUMT00000257409
      Conserved Domains (1) summary
      cl27628
      Location:8799
      Gastrin; Gastrin/cholecystokinin family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p7 Primary Assembly

      Range
      41712326..41715969
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      40104051..40107693
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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