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    Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha [ Mus musculus (house mouse) ]

    Gene ID: 18035, updated on 22-Apr-2017
    Official Symbol
    Nfkbiaprovided by MGI
    Official Full Name
    nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alphaprovided by MGI
    Primary source
    MGI:MGI:104741
    See related
    Ensembl:ENSMUSG00000021025
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nfkbi; AI462015
    Orthologs
    Location:
    12; 12 C1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (55489409..55492647, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (56590396..56593634, complement)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene mitochondrial import inner membrane translocase subunit Tim8 B pseudogene Neighboring gene predicted gene, 36571 Neighboring gene predicted gene, 36634 Neighboring gene aldolase 1 A, retrogene 2

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NF-kappaB binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear localization sequence binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to biotic stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to cytokine stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoplasmic sequestering of NF-kappaB ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic sequestering of transcription factor ISO
    Inferred from Sequence Orthology
    more info
     
    lipopolysaccharide-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of lipid storage ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of macrophage derived foam cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of myeloid cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nucleotide-binding oligomerization domain containing 1 signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleotide-binding oligomerization domain containing 2 signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cellular protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein import into nucleus, translocation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to exogenous dsRNA IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to muramyl dipeptide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to muscle stretch IDA
    Inferred from Direct Assay
    more info
    PubMed 
    toll-like receptor 4 signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    intracellular ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    NF-kappa-B inhibitor alpha
    Names
    I(Kappa)B(alpha)
    I-kappa-B-alpha
    I-kappaBalpha
    ikB-alpha
    ikappaBalpha
    nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha
    nuclear factor of kappa light polyp gene enhancer in B-cell 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010907.2NP_035037.2  NF-kappa-B inhibitor alpha

      See identical proteins and their annotated locations for NP_035037.2

      Status: VALIDATED

      Source sequence(s)
      AC158398, AI462015, BC046754, CF379853
      Consensus CDS
      CCDS25918.1
      UniProtKB/Swiss-Prot
      Q9Z1E3
      Related
      ENSMUSP00000021413.7, ENSMUST00000021413.8
      Conserved Domains (4) summary
      cd00204
      Location:105237
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:115212
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:202256
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:143180
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      55489409..55492647 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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