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    ELAVL4 ELAV like RNA binding protein 4 [ Homo sapiens (human) ]

    Gene ID: 1996, updated on 3-Jun-2018
    Official Symbol
    ELAVL4provided by HGNC
    Official Full Name
    ELAV like RNA binding protein 4provided by HGNC
    Primary source
    HGNC:HGNC:3315
    See related
    Ensembl:ENSG00000162374 MIM:168360; Vega:OTTHUMG00000007877
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HUD; PNEM
    Expression
    Biased expression in brain (RPKM 9.5), adrenal (RPKM 2.6) and 2 other tissues See more
    Orthologs
    See ELAVL4 in Genome Data Viewer
    Location:
    1p33-p32.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (50048014..50203786)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (50513686..50669442)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATP/GTP binding protein like 4 Neighboring gene uncharacterized LOC105378708 Neighboring gene uncharacterized LOC105378709 Neighboring gene heart enhancer 18 Neighboring gene MT-ND2 pseudogene 29 Neighboring gene uncharacterized LOC107984955 Neighboring gene uncharacterized LOC105378711 Neighboring gene uncharacterized LOC105378710 Neighboring gene uncharacterized LOC105378712

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    AU-rich element binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    mRNA 3'-UTR binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    RNA processing TAS
    Traceable Author Statement
    more info
    PubMed 
    mRNA processing TAS
    Traceable Author Statement
    more info
    PubMed 
    Preferred Names
    ELAV-like protein 4
    Names
    ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
    ELAV like neuron-specific RNA binding protein 4
    Hu antigen D
    paraneoplastic encephalomyelitis antigen HuD

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001144774.2NP_001138246.1  ELAV-like protein 4 isoform 2

      See identical proteins and their annotated locations for NP_001138246.1

      Status: VALIDATED

      Source sequence(s)
      AL592182, AY033997, BC036071, CK005107
      Consensus CDS
      CCDS44140.1
      UniProtKB/Swiss-Prot
      P26378
      Related
      ENSP00000360889.1, OTTHUMP00000009611, ENST00000371824.5, OTTHUMT00000021711
      Conserved Domains (1) summary
      TIGR01661
      Location:43365
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    2. NM_001144775.2NP_001138247.2  ELAV-like protein 4 isoform 3

      See identical proteins and their annotated locations for NP_001138247.2

      Status: VALIDATED

      Source sequence(s)
      AL592182, AY033996, BC036071, BM509527
      Consensus CDS
      CCDS44139.2
      UniProtKB/Swiss-Prot
      P26378
      UniProtKB/TrEMBL
      A0A0R4J2E6
      Related
      ENSP00000349594.5, OTTHUMP00000009610, ENST00000357083.8, OTTHUMT00000021710
      Conserved Domains (1) summary
      TIGR01661
      Location:79401
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    3. NM_001144776.2NP_001138248.1  ELAV-like protein 4 isoform 4

      See identical proteins and their annotated locations for NP_001138248.1

      Status: VALIDATED

      Source sequence(s)
      AL592182, AY033995, BC036071
      Consensus CDS
      CCDS44138.1
      UniProtKB/Swiss-Prot
      P26378
      Related
      ENSP00000360892.1, OTTHUMP00000009609, ENST00000371827.5, OTTHUMT00000021709
      Conserved Domains (1) summary
      TIGR01661
      Location:43365
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    4. NM_001144777.2NP_001138249.1  ELAV-like protein 4 isoform 5

      See identical proteins and their annotated locations for NP_001138249.1

      Status: VALIDATED

      Source sequence(s)
      AL592182, BC036071, DC351092
      Consensus CDS
      CCDS53315.1
      UniProtKB/Swiss-Prot
      P26378
      Related
      ENSP00000399939.2, ENST00000448907.6
      Conserved Domains (1) summary
      TIGR01661
      Location:46368
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    5. NM_001294348.1NP_001281277.1  ELAV-like protein 4 isoform 6

      See identical proteins and their annotated locations for NP_001281277.1

      Status: VALIDATED

      Source sequence(s)
      AK298902, AL583843, AL592182, BC036071
      Consensus CDS
      CCDS72788.1
      UniProtKB/Swiss-Prot
      P26378
      UniProtKB/TrEMBL
      B1APY9
      Related
      ENSP00000360884.1, OTTHUMP00000009614, ENST00000371819.1, OTTHUMT00000021714
      Conserved Domains (1) summary
      TIGR01661
      Location:48370
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    6. NM_001324208.1NP_001311137.1  ELAV-like protein 4 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL583843, AL592182, AL645730
      Conserved Domains (4) summary
      cd12650
      Location:48125
      RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
      cd12656
      Location:297382
      RRM3_HuD; RNA recognition motif 3 in vertebrate Hu-antigen D (HuD)
      TIGR01661
      Location:46382
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cl17169
      Location:130219
      RRM_SF; RNA recognition motif (RRM) superfamily
    7. NM_001324209.1NP_001311138.1  ELAV-like protein 4 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL583843, AL592182
      Conserved Domains (1) summary
      TIGR01661
      Location:42351
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    8. NM_001324212.1NP_001311141.1  ELAV-like protein 4 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AL583843, AL592182
      Conserved Domains (1) summary
      TIGR01661
      Location:42364
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    9. NM_001324213.1NP_001311142.1  ELAV-like protein 4 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL583843, AL592182
      Consensus CDS
      CCDS81321.1
      UniProtKB/TrEMBL
      B1APY8
      Related
      ENSP00000360886.1, OTTHUMP00000009613, ENST00000371821.5, OTTHUMT00000021713
      Conserved Domains (1) summary
      TIGR01661
      Location:48384
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    10. NM_001324214.1NP_001311143.1  ELAV-like protein 4 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AL583843, AL592182
      Conserved Domains (1) summary
      TIGR01661
      Location:42364
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    11. NM_001324215.1NP_001311144.1  ELAV-like protein 4 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL583843, AL592182
      Conserved Domains (1) summary
      TIGR01661
      Location:48357
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    12. NM_001324216.1NP_001311145.1  ELAV-like protein 4 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AL583843, AL592182
      Conserved Domains (1) summary
      cd12650
      Location:45118
      RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
    13. NM_001324217.1NP_001311146.1  ELAV-like protein 4 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AL583843, AL592182
      Conserved Domains (1) summary
      cd12650
      Location:50123
      RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
    14. NM_021952.4NP_068771.2  ELAV-like protein 4 isoform 1

      See identical proteins and their annotated locations for NP_068771.2

      Status: VALIDATED

      Source sequence(s)
      AL592182, AY033998, BC036071, CK005107
      Consensus CDS
      CCDS553.1
      UniProtKB/Swiss-Prot
      P26378
      Related
      ENSP00000360888.4, OTTHUMP00000009612, ENST00000371823.8, OTTHUMT00000021712
      Conserved Domains (1) summary
      TIGR01661
      Location:43379
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    RNA

    1. NR_136725.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL583843, AL592182

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      50048014..50203786
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017000542.1XP_016856031.1  ELAV-like protein 4 isoform X13

      Conserved Domains (1) summary
      cd12650
      Location:48121
      RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
    2. XM_024453827.1XP_024309595.1  ELAV-like protein 4 isoform X9

      Conserved Domains (1) summary
      TIGR01661
      Location:36358
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    3. XM_011540893.2XP_011539195.1  ELAV-like protein 4 isoform X4

      See identical proteins and their annotated locations for XP_011539195.1

      Conserved Domains (4) summary
      cd12650
      Location:45122
      RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
      cd12656
      Location:294379
      RRM3_HuD; RNA recognition motif 3 in vertebrate Hu-antigen D (HuD)
      TIGR01661
      Location:43379
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cl17169
      Location:127216
      RRM_SF; RNA recognition motif (RRM) superfamily
    4. XM_017000541.1XP_016856030.1  ELAV-like protein 4 isoform X12

    5. XM_017000538.1XP_016856027.1  ELAV-like protein 4 isoform X5

      Conserved Domains (4) summary
      cd12650
      Location:58135
      RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
      cd12656
      Location:293378
      RRM3_HuD; RNA recognition motif 3 in vertebrate Hu-antigen D (HuD)
      TIGR01661
      Location:56378
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cl17169
      Location:140229
      RRM_SF; RNA recognition motif (RRM) superfamily
    6. XM_006710411.3XP_006710474.1  ELAV-like protein 4 isoform X2

      See identical proteins and their annotated locations for XP_006710474.1

      Conserved Domains (4) summary
      cd12650
      Location:58135
      RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
      cd12656
      Location:307392
      RRM3_HuD; RNA recognition motif 3 in vertebrate Hu-antigen D (HuD)
      TIGR01661
      Location:56392
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cl17169
      Location:140229
      RRM_SF; RNA recognition motif (RRM) superfamily
    7. XM_011540889.3XP_011539191.1  ELAV-like protein 4 isoform X1

      See identical proteins and their annotated locations for XP_011539191.1

      Conserved Domains (4) summary
      cd12650
      Location:81158
      RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
      cd12656
      Location:330415
      RRM3_HuD; RNA recognition motif 3 in vertebrate Hu-antigen D (HuD)
      cd12775
      Location:163252
      RRM2_HuB; RNA recognition motif 2 in vertebrate Hu-antigen B (HuB)
      TIGR01661
      Location:79415
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    8. XM_017000540.1XP_016856029.1  ELAV-like protein 4 isoform X11

    9. XM_011540890.2XP_011539192.1  ELAV-like protein 4 isoform X3

      See identical proteins and their annotated locations for XP_011539192.1

      Conserved Domains (4) summary
      cd12650
      Location:81158
      RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
      cd12656
      Location:303388
      RRM3_HuD; RNA recognition motif 3 in vertebrate Hu-antigen D (HuD)
      TIGR01661
      Location:79388
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cl17169
      Location:163252
      RRM_SF; RNA recognition motif (RRM) superfamily
    10. XM_024453829.1XP_024309597.1  ELAV-like protein 4 isoform X10

      Conserved Domains (1) summary
      TIGR01661
      Location:43352
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    11. XM_011540895.3XP_011539197.1  ELAV-like protein 4 isoform X6

      See identical proteins and their annotated locations for XP_011539197.1

      Conserved Domains (4) summary
      cd12650
      Location:44121
      RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
      cd12656
      Location:293378
      RRM3_HuD; RNA recognition motif 3 in vertebrate Hu-antigen D (HuD)
      TIGR01661
      Location:42378
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cl17169
      Location:126215
      RRM_SF; RNA recognition motif (RRM) superfamily
    12. XM_011540894.2XP_011539196.1  ELAV-like protein 4 isoform X6

      See identical proteins and their annotated locations for XP_011539196.1

      Conserved Domains (4) summary
      cd12650
      Location:44121
      RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
      cd12656
      Location:293378
      RRM3_HuD; RNA recognition motif 3 in vertebrate Hu-antigen D (HuD)
      TIGR01661
      Location:42378
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cl17169
      Location:126215
      RRM_SF; RNA recognition motif (RRM) superfamily
    13. XM_024453822.1XP_024309590.1  ELAV-like protein 4 isoform X7

      Conserved Domains (1) summary
      TIGR01661
      Location:55377
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    14. XM_024453825.1XP_024309593.1  ELAV-like protein 4 isoform X8

      Conserved Domains (1) summary
      TIGR01661
      Location:42364
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    15. XM_017000539.1XP_016856028.1  ELAV-like protein 4 isoform X9

      Conserved Domains (1) summary
      TIGR01661
      Location:36358
      ELAV_HUD_SF; ELAV/HuD family splicing factor
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