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    AKAP11 A-kinase anchoring protein 11 [ Homo sapiens (human) ]

    Gene ID: 11215, updated on 4-Jun-2017
    Official Symbol
    AKAP11provided by HGNC
    Official Full Name
    A-kinase anchoring protein 11provided by HGNC
    Primary source
    HGNC:HGNC:369
    See related
    Ensembl:ENSG00000023516 MIM:604696; Vega:OTTHUMG00000016805
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRKA11; AKAP-11; AKAP220; PPP1R44
    Summary
    The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed at high levels throughout spermatogenesis and in mature sperm. It binds the RI and RII subunits of PKA in testis. It may serve a function in cell cycle control of both somatic cells and germ cells in addition to its putative role in spermatogenesis and sperm function. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    13q14.11
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 13 NC_000013.11 (42271470..42323267)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (42846261..42897403)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene diacylglycerol kinase eta Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 11 Neighboring gene fumarate hydratase pseudogene 1 Neighboring gene fatty acid binding protein 3 pseudogene 2 Neighboring gene long intergenic non-protein coding RNA 2341

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
    NHGRI GWA Catalog
    Multistage genome-wide association meta-analyses identified two new loci for bone mineral density.
    NHGRI GWA Catalog
    Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.
    NHGRI GWA Catalog
    • G Protein Signaling Pathways, organism-specific biosystem (from WikiPathways)
      G Protein Signaling Pathways, organism-specific biosystemG proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades. G proteins are so called because they function as "molecular switches". They...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ11304, KIAA0629, DKFZp781I12161

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein kinase A binding TAS
    Traceable Author Statement
    more info
    PubMed 
    protein phosphatase 1 binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    intracellular signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of protein kinase A signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    microtubule organizing center IEA
    Inferred from Electronic Annotation
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
     
    peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    Preferred Names
    A-kinase anchor protein 11
    Names
    A kinase (PRKA) anchor protein 11
    A-kinase anchor protein 220 kDa
    A-kinase anchoring protein, 220kDa
    a kinase anchor protein 220 kDa
    protein kinase A anchoring protein 11
    protein phosphatase 1, regulatory subunit 44

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016248.3NP_057332.1  A-kinase anchor protein 11

      See identical proteins and their annotated locations for NP_057332.1

      Status: REVIEWED

      Source sequence(s)
      AF176555, AL136527, BE670178, BE694434, DA780016
      Consensus CDS
      CCDS9383.1
      UniProtKB/Swiss-Prot
      Q9UKA4
      Related
      ENSP00000025301.2, OTTHUMP00000018327, ENST00000025301.3, OTTHUMT00000044700
      Conserved Domains (1) summary
      cl14906
      Location:18041900
      AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p7 Primary Assembly

      Range
      42271470..42323267
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011534906.2XP_011533208.1  A-kinase anchor protein 11 isoform X1

      See identical proteins and their annotated locations for XP_011533208.1

      UniProtKB/Swiss-Prot
      Q9UKA4
      Conserved Domains (1) summary
      cl14906
      Location:18041900
      AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)
    2. XM_017020383.1XP_016875872.1  A-kinase anchor protein 11 isoform X3

      Conserved Domains (1) summary
      cl14906
      Location:17591855
      AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)
    3. XM_011534904.1XP_011533206.1  A-kinase anchor protein 11 isoform X1

      See identical proteins and their annotated locations for XP_011533206.1

      UniProtKB/Swiss-Prot
      Q9UKA4
      Conserved Domains (1) summary
      cl14906
      Location:18041900
      AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)
    4. XM_011534903.2XP_011533205.1  A-kinase anchor protein 11 isoform X1

      See identical proteins and their annotated locations for XP_011533205.1

      UniProtKB/Swiss-Prot
      Q9UKA4
      Conserved Domains (1) summary
      cl14906
      Location:18041900
      AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)
    5. XM_005266248.3XP_005266305.1  A-kinase anchor protein 11 isoform X3

      Conserved Domains (1) summary
      cl14906
      Location:17591855
      AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)
    6. XM_017020382.1XP_016875871.1  A-kinase anchor protein 11 isoform X3

      Conserved Domains (1) summary
      cl14906
      Location:17591855
      AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)
    7. XM_005266247.1XP_005266304.1  A-kinase anchor protein 11 isoform X2

      Conserved Domains (1) summary
      cl14906
      Location:16551872
      AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)
    8. XM_011534905.1XP_011533207.1  A-kinase anchor protein 11 isoform X1

      See identical proteins and their annotated locations for XP_011533207.1

      UniProtKB/Swiss-Prot
      Q9UKA4
      Conserved Domains (1) summary
      cl14906
      Location:18041900
      AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)
    9. XM_005266249.3XP_005266306.1  A-kinase anchor protein 11 isoform X4

    10. XM_005266250.3XP_005266307.1  A-kinase anchor protein 11 isoform X5

    11. XM_017020381.1XP_016875870.1  A-kinase anchor protein 11 isoform X1

      UniProtKB/Swiss-Prot
      Q9UKA4
      Conserved Domains (1) summary
      cl14906
      Location:18041900
      AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)

    Alternate CHM1_1.1

    Genomic

    1. NC_018924.2 Alternate CHM1_1.1

      Range
      42813753..42864863
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_144490.1: Suppressed sequence

      Description
      NM_144490.1: This RefSeq was permanently suppressed because its 3' end is primarily intronic sequence.
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