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    ABCC10 ATP binding cassette subfamily C member 10 [ Homo sapiens (human) ]

    Gene ID: 89845, updated on 11-Jun-2017
    Official Symbol
    ABCC10provided by HGNC
    Official Full Name
    ATP binding cassette subfamily C member 10provided by HGNC
    Primary source
    HGNC:HGNC:52
    See related
    Ensembl:ENSG00000124574 MIM:612509; Vega:OTTHUMG00000014733
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MRP7; SIMRP7; EST182763
    Summary
    The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2010]
    Orthologs
    Location:
    6p21.1
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 6 NC_000006.12 (43427538..43451994)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (43395282..43418163)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene zinc finger protein 318 Neighboring gene ribosomal protein S2 pseudogene 28 Neighboring gene uncharacterized LOC105375065 Neighboring gene microRNA 6780b Neighboring gene uncharacterized LOC107986597 Neighboring gene delta like non-canonical Notch ligand 2 Neighboring gene RNA, U6 small nuclear 1113, pseudogene

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • ABC transporters, organism-specific biosystem (from KEGG)
      ABC transporters, organism-specific biosystemThe ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of ...
    • ABC transporters, conserved biosystem (from KEGG)
      ABC transporters, conserved biosystemThe ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of ...
    • ABC-family proteins mediated transport, organism-specific biosystem (from REACTOME)
      ABC-family proteins mediated transport, organism-specific biosystemThe ATP-binding cassette (ABC) superfamily of active transporters involves a large number of functionally diverse transmembrane proteins. They transport a variety of compounds through membranes agai...
    • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
      Transmembrane transport of small molecules, organism-specific biosystem
      Transmembrane transport of small molecules
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity, coupled to transmembrane movement of substances IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ATPase-coupled anion transmembrane transporter activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    ATP hydrolysis coupled anion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transmembrane transport TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    multidrug resistance-associated protein 7
    Names
    ATP-binding cassette sub-family C member 10
    ATP-binding cassette, sub-family C (CFTR/MRP), member 10

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198934.1NP_001185863.1  multidrug resistance-associated protein 7 isoform MRP7

      See identical proteins and their annotated locations for NP_001185863.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MRP7) encodes the longest isoform (MRP7).
      Source sequence(s)
      AK000002, AY032599
      Consensus CDS
      CCDS56430.1
      UniProtKB/Swiss-Prot
      Q5T3U5
      UniProtKB/TrEMBL
      A0A024RD21
      Related
      ENSP00000361608.4, OTTHUMP00000016438, ENST00000372530.8, OTTHUMT00000040603
      Conserved Domains (4) summary
      cd03244
      Location:12441463
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:598801
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      TIGR01271
      Location:2191469
      CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
      cl00549
      Location:289551
      ABC_membrane; ABC transporter transmembrane region
    2. NM_001350518.1NP_001337447.1  multidrug resistance-associated protein 7 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) encodes isoform 3.
      Source sequence(s)
      AL359813
    3. NM_033450.2NP_258261.2  multidrug resistance-associated protein 7 isoform MRP7A

      See identical proteins and their annotated locations for NP_258261.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MRP7A), also known as SIMRP7, has multiple differences, compared to variant MRP7. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant MRP7. The encoded protein (isoform MRP7A) is shorter than isoform MRP7.
      Source sequence(s)
      AY032599
      Consensus CDS
      CCDS4896.1
      UniProtKB/Swiss-Prot
      Q5T3U5
      Related
      ENSP00000244533.3, OTTHUMP00000016441, ENST00000244533.7, OTTHUMT00000040608
      Conserved Domains (4) summary
      cd03244
      Location:12161435
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:570773
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      TIGR01271
      Location:1761441
      CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
      cl00549
      Location:246508
      ABC_membrane; ABC transporter transmembrane region

    RNA

    1. NR_146762.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL359813

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p7 Primary Assembly

      Range
      43427538..43451994
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017011446.1XP_016866935.1  multidrug resistance-associated protein 7 isoform X3

    2. XM_017011447.1XP_016866936.1  multidrug resistance-associated protein 7 isoform X3

    3. XM_017011452.1XP_016866941.1  multidrug resistance-associated protein 7 isoform X7

    4. XM_011514983.2XP_011513285.1  multidrug resistance-associated protein 7 isoform X10

      Conserved Domains (5) summary
      TIGR03608
      Location:176351
      L_ocin_972_ABC; putative bacteriocin export ABC transporter, lactococcin 972 group
      cd03244
      Location:8001019
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:154357
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      COG4987
      Location:4851022
      CydC; ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion, Posttranslational modification, protein turnover, chaperones]
      cl00549
      Location:515747
      ABC_membrane; ABC transporter transmembrane region
    5. XM_017011453.1XP_016866942.1  multidrug resistance-associated protein 7 isoform X8

    6. XM_017011451.1XP_016866940.1  multidrug resistance-associated protein 7 isoform X6

    7. XM_017011449.1XP_016866938.1  multidrug resistance-associated protein 7 isoform X4

    8. XM_017011448.1XP_016866937.1  multidrug resistance-associated protein 7 isoform X4

    9. XM_017011450.1XP_016866939.1  multidrug resistance-associated protein 7 isoform X5

    10. XM_017011445.1XP_016866934.1  multidrug resistance-associated protein 7 isoform X1

    11. XM_011514974.2XP_011513276.2  multidrug resistance-associated protein 7 isoform X2

    12. XM_017011454.1XP_016866943.1  multidrug resistance-associated protein 7 isoform X9

    13. XM_017011455.1XP_016866944.1  multidrug resistance-associated protein 7 isoform X9

    14. XM_011514986.2XP_011513288.1  multidrug resistance-associated protein 7 isoform X11

      See identical proteins and their annotated locations for XP_011513288.1

      Conserved Domains (4) summary
      cd03244
      Location:593812
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:2150
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      COG4987
      Location:278815
      CydC; ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion, Posttranslational modification, protein turnover, chaperones]
      cl00549
      Location:308540
      ABC_membrane; ABC transporter transmembrane region
    15. XM_017011456.1XP_016866945.1  multidrug resistance-associated protein 7 isoform X11

      Conserved Domains (4) summary
      cd03244
      Location:593812
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:2150
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      COG4987
      Location:278815
      CydC; ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion, Posttranslational modification, protein turnover, chaperones]
      cl00549
      Location:308540
      ABC_membrane; ABC transporter transmembrane region
    16. XM_011514985.2XP_011513287.1  multidrug resistance-associated protein 7 isoform X11

      See identical proteins and their annotated locations for XP_011513287.1

      Conserved Domains (4) summary
      cd03244
      Location:593812
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:2150
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      COG4987
      Location:278815
      CydC; ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion, Posttranslational modification, protein turnover, chaperones]
      cl00549
      Location:308540
      ABC_membrane; ABC transporter transmembrane region

    RNA

    1. XR_001743721.1 RNA Sequence

    2. XR_001743722.1 RNA Sequence

    3. XR_001743723.1 RNA Sequence

    4. XR_001743720.1 RNA Sequence

    5. XR_001743719.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018917.2 Alternate CHM1_1.1

      Range
      43398442..43421307
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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